Questions tagged [genetics]
Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.
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Knock-Out (KO) Mice
We have generated an induced KO mice line for a specific gene. However when i perform IF staining I can still see substantial levels of the protein for this specific gene produced, even though the ...
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How are genetic hallmarks of aging somehow “reset” at conception?
I’m a layman and genuinely curious about this, so forgive me if I use the wrong terminology or obviously don’t know what I’m talking about. Regardless of whether parents have a child at 18 or at 40, ...
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Probability of an $AABbCC$ offspring given the cross $AaBbCc\times AaBbCc$, is my solution correct?
So I have been working through the drills in the 26th edition of AP Biology Prep by The Princeton Review for fun when I came across this question in the Chapter 12 drill that I'm not really sure about ...
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What does it mean when observed genotype frequency is different from expected genotype frequency in Hardy-Weinberg equilibrium?
As I understand it, if a population is at Hardy-Weinberg equilibrium, then the genotype frequencies should be $$p^2 + 2pq + q^2 = 1,$$ given the allele frequencies of $p$ and $q$, which you can figure ...
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In the context of GWAS we have an alternate allele and a reference allele. Why do we only have one possible alternate instead of three?
I recently started analyzing a GWAS summary dataset. It has a column for the reference allele in which it mentions the base in the reference genome.
There is another column for the alternate allele (...
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If you want to understand evolution from a genetics standpoint what are some must reads be it books or textbooks? [closed]
The question basically sums it up. I'm looking for books/textbooks that explain evolution from a genetic perspective.
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Interpretation of narrow-sense heritability over one (using R/S = h^2)
Here is my data:
Mean height score of the total parental population: 5.2
Mean height score of selected parents (those chosen for breeding due to their higher height): 6.4
Mean height score of the ...
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What is important in the Luria-Latarjet effect?
In the seminal paper
Luria, S.E. and Latarjet, R. (1964) “Ultraviolet irradiation of
bacteriophage during intracellular growth”. Proceedings of the
National Academy of Sciences of the United States ...
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Evolution of the human Y chromosome
This recent news article suggests the number of genes in human male Y chromosome has steadily been reducing in the Y chromosome for a long time and is in danger of dying out all together.
What I want ...
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Is there a program that demonstrates overall fitness will increase in a population overtime?
Of course this will not always be the case with environmental factors, but generally speaking. I'm searching for a program that shows evolution works from a statistical standpoint.
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What is the word for a small (under 50 bp) structural variant?
What is the word for a small (under 50 bp) SV? Perhaps it is MNV (multi-nucleotide variant)? Something like microindel? I do not like SNV as "single nucleotide" is not really correct and I ...
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Pedigree Analysis
I was doing some pedigree work and couldn't figure out why my answer is wrong. This chart is supposed to be an autosomal Dominant method of inheritance, but I am finding an autosomal recessive pattern ...
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Why do we choose to use agar instead of agarose in various microbial applications?
When performing gel-electrophoresis we always use agarose. Is there a reason we can't perform it using Agar?
And in microbial culture Agar is commonly used as solidifying agent, could this be replaced ...
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Preserving a sample for mtDNA and nuclear DNA analysis
Imagine a person in the early half of the 20th century (1900 to 1950) took some kind of sample(s) from a living human body using any technology of the era. They then stored it using any technology ...
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With CRISPR-mediated gene editing, can the PAM for the guide RNA also be site of the desired edit?
I'm hoping to use CRISPR-Cas9 in yeast to change a single nucleotide in a gene of interest. While there are a couple potential guide RNA sequences I could use, the best option's PAM sequence (TGG) it ...
