All Questions
Tagged with genetics recombination
44
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How did the Zinder-Lederberg experiment on Transduction work?
In the paper that introduced TRANSDUCTION (J Bacteriol. 1952 Nov;64(5):679-699), Lederberg and his student Zinder reported that S. typhimurium
"LT-22 is lysogenic for a virus active on LT-2. ...
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What software can be used for simulating human meiosis, taking linkage and recombination into account?
I want to study the nature of genetic variation in offspring from the same set of human parents. To this end, I would like to take two (male and female) complete genomes, generate gametes from them, ...
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Why is the maximum propotion of MII 2/3 in the ordered tetrad analysis? How is it different from normal recombination?
My textbook says that the maximum propotion of MII gametes in the ordered tetrad analysis is 2/3, and if we put it into the formula RF(recombination frequency)=MII/2(MI+MII), we can find out that the ...
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How frequently does recombination occur, and how long are the recombinated fragments?
I understand the mechanics of recombination, but am struggling with the 'scale'.
When two homologous chromosomes pair, roughly how many recombination events occur on average? I understand there will ...
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Why do many plasmids for Flp-mediated Flip-Excision only flanked by one FRT site on each side and not two non-homologous?
I'm trying to build some molecular gene switches into a model, and want to use both Cre and Flp. I understand how to invert gene segments with Cre, double floxing (e.g. with loxP and lox2272, like in ...
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Trying to find information about intraspecific allelic expression divergence in recombinant individuals due to changes in the cis regulatory regions
I am trying to find any research articles or resources that focus on differences in expression levels at the allelic level due to changes in cis regulatory regions in recombinant individuals. For ...
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How random is genetic recombination?
Two parents can have a very large number of different potential offsprings, and it's common knowledge that the daughter chromosomes in meiosis are produced randomly, i.e. in crossover, the exact spots ...
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What does the term "centromere linkage" mean in genetics?
I am currently learning about tetrad/linkage analysis in yeast. I have read two statements similar to this:
If two genes are unlinked, but linked to the centromere the distribution will be 50 ...
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What are the differences between different strains/types of Cre?
Reading from Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state:
Lineage-specific genetic tools are necessary to precisely study HF
fibroblasts; however, their ...
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What is an intuitive explanation of linkage disequilibrium?
Is it possible to give a simple and intuitive explanation of the concept of linkage disequilibrium? You know, so I can sort of sound like I know what I'm talking about. Everything I read about it has ...
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How can I find/simulate mixed-ancestry DNA data?
Some collaborators and I are building an ancestral inference tool, and we're having trouble obtaining reliable ground-truth data for samples of mixed ancestry. All the ground-truth DNA datasets we're ...
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Gametes produced after single and double cross overs
A female genotype, shown as abc / +++ produces 100 meiotic
tetrads. Among these, 68 showed no cross over (NCO) events; 20 showed
single crossover (SCO1) between a and b; 10 showed single crossover
...
2
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191
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Number of homozygous recessive offspring
A question from the KVPY-SX examination, organised by the Indian Institute of Science (IISc) in Bengaluru, India, held on 3rd November, 2019.
A plant heterozygous for height and flower colour (TtRr) ...
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How can we know which alleles are together on a chromosome?
This illustration says that if the two homozygotes pr+ pr+ vg+ vg+ and pr pr vg vg are crossed to produce a heterozygous offspring (pr+ pr vg+ vg), then:
this cross gives us exactly what we need to ...
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What is the map unit between the genes?
While doing some biology I came across this question:
The following tables present results of plant crosses involving two linked genes: S is a seed-color gene, and L is a plant-height gene. Each gene ...
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