All Questions
Tagged with genetics population-genetics
151
questions
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121
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What does it mean when observed genotype frequency is different from expected genotype frequency in Hardy-Weinberg equilibrium?
As I understand it, if a population is at Hardy-Weinberg equilibrium, then the genotype frequencies should be $$p^2 + 2pq + q^2 = 1,$$ given the allele frequencies of $p$ and $q$, which you can figure ...
0
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1
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30
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In the context of GWAS we have an alternate allele and a reference allele. Why do we only have one possible alternate instead of three?
I recently started analyzing a GWAS summary dataset. It has a column for the reference allele in which it mentions the base in the reference genome.
There is another column for the alternate allele (...
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3
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97
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If you want to understand evolution from a genetics standpoint what are some must reads be it books or textbooks? [closed]
The question basically sums it up. I'm looking for books/textbooks that explain evolution from a genetic perspective.
1
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2
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59
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Interpretation of narrow-sense heritability over one (using R/S = h^2)
Here is my data:
Mean height score of the total parental population: 5.2
Mean height score of selected parents (those chosen for breeding due to their higher height): 6.4
Mean height score of the ...
0
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0
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31
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Is there a program that demonstrates overall fitness will increase in a population overtime?
Of course this will not always be the case with environmental factors, but generally speaking. I'm searching for a program that shows evolution works from a statistical standpoint.
0
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19
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Why is the expected time to coalesce the same as the ploidy times inbreeding effective population size?
The expected time to coalesce, in generations, is the same as the ploidy (e.g., 2 for humans) times Nef, the inbreeding effective population size, under coalescent
theory. Why?
Both ploidy * Nef and ...
0
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3
answers
110
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Have there ever been "half-twins" who were halfway between siblings and twins?
Have there ever been two human siblings who were 75% or more genetically related?
0
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25
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Coefficient of fraternity between grandparent and grandchild from full-sib parents
I have the following pedigree and I would like to calculate the coefficient of fraternity between individual 1 and 5. R/AGHmatrix::Amatrix gives a coefficient of 0 for this pair. Shouldn't it be non-...
0
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2
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136
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Hardy-Weinberg Equilibrium Test Result for Merged Genotypes
I was curious if two populations are in Hardy-Weinberg Equilibrium (HWE), and if they are merged, then what happens? To find out, I considered populations from the 1000 genome project data. For ...
0
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0
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61
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Do multiple alleles undergo crossover?
For a reference, point 3 of this article: https://www.biologydiscussion.com/genetics/multiple-alleles/multiple-alleles-meaning-characteristics-and-examples-genes/35452
According to google Bard and ...
1
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1
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81
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Are there two different senses of the word 'heritability' in use?
Target Height as Predicted by Parental Heights in a Population-Based Study states:
The heritability value was taken as the regression coefficient between
final height and midparental height
Is this ...
0
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1
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50
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Is there a term for a sequence of genomes for a family?
Suppose that I am following how a "familial" genome changes throughout generations. That is, I have the genome of a grandmother, father, and daughter, and my objective is to see how the ...
5
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1
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137
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How exactly do mutations cause genetic variation in bilaterians?
I am trying to understand how mutations cause genetic variance, and I'm stuck on one issue that I'm going to try my best to explain.
(I am specifically talking about mutations that cause a ...
3
votes
1
answer
89
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How is a haploblock defined with only one SNP location?
I am reading Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis – a cohort study and am looking at Figure 1. I understand that haplotypes are associated with ...
0
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1
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135
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Disease-causing allele frequency and modern medicine
I was thinking about what the impact modern medicine might have on human evolution based on a couple assumptions.
If we assume that:
modern medicine has massively cushioned the selection pressure ...