All Questions
69
questions
0
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1
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30
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In the context of GWAS we have an alternate allele and a reference allele. Why do we only have one possible alternate instead of three?
I recently started analyzing a GWAS summary dataset. It has a column for the reference allele in which it mentions the base in the reference genome.
There is another column for the alternate allele (...
- 101
0
votes
3
answers
110
views
Have there ever been "half-twins" who were halfway between siblings and twins?
Have there ever been two human siblings who were 75% or more genetically related?
- 401
0
votes
1
answer
76
views
Gene Mapping - Please explain in Lay terms
Taking an AP bio course, and for some reason I cannot comprehend the mechanism of how one determines the location of alleles on a chromosome. The math is simple and I can memorize it, but its bugging ...
2
votes
1
answer
212
views
Considering Two Genes, Are There Only Two Possible Outcomes for the Four Gametes Produced After Meiosis, Regardless of Independent Assortment?
Is it true that for a single meiotic event when considering only two genes, there are only two possible genetic outcomes among the four gametes produced, regardless of whether the two genes are found ...
- 139
1
vote
0
answers
24
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Trying to find information about intraspecific allelic expression divergence in recombinant individuals due to changes in the cis regulatory regions
I am trying to find any research articles or resources that focus on differences in expression levels at the allelic level due to changes in cis regulatory regions in recombinant individuals. For ...
- 11
0
votes
2
answers
155
views
What really is an allele?
My textbook says:
genes which code for a pair of contrasting traits are known as alleles.
Then that means T and t are alleles. Further, it says:
Mendel also proposed that in a true breeding, tall ...
- 1
2
votes
0
answers
65
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Inferring mother's allele probability based on father and children
I am currently in the process of analyzing our family's genome. I do have access to his, mine and our father's genome, but not to our mother's (deceased). I was wondering how I could combine our 3 ...
0
votes
2
answers
119
views
Can gene mutations cause Down's syndrome in humans?
I am working on an A levels questions:
Which of the following statements about gene mutation is incorrect?
A. It can occur in both somatic and sex cells
B. It can cause Down's syndrome in humans
C. ...
- 297
2
votes
1
answer
96
views
What is meant by 'identical alleles'?
I read in my book that "two alleles are considered to be homozygous if they are identical". But at the same time I read the definition of allele to be:
genes which code for a pair of ...
- 23
2
votes
0
answers
70
views
What is the heredity model of the following heredity tree?
I have the following heredity tree:
and I need to decide which heredity model it fits the most, with the least number of assumptions, from the following models:
autosome dominant
autosome recessive
...
- 139
2
votes
1
answer
398
views
How can a minor allele frequency be >50% (reported in GNOMAD)?
I'm receiving a data set to start an analysis. My collaborators ran GATK to find variants from sequencing data, and GNOMAD calculated the minor allele frequencies - and then I'm receiving this MAF ...
- 121
0
votes
1
answer
189
views
Could someone explain how chromosomes are counted here?
I'm not sure how chromosomes are counted in this picture. I would reason that there would be 8 chromosomes in the diploid cell, but that doesn't seem to be the case. Could someone explain?
- 21
1
vote
1
answer
161
views
How is it determined whether a chromosome is maternal or paternal for imprinting?
For imprinting, how does the cell determine which chromosome is maternal and which is paternal? For example, in the parental imprinting of insulin-like growth factor 2 (Igf2) on chr7 (autosome), how ...
0
votes
1
answer
295
views
Is it possible for a brown cat to birth an orange kitten?
I have a brown (cinnamon) cat, I assume her alleles would be b’b’ and oo. She was bred with either a black male (B_ o) or an orange male (__ O), or both if it’s possible for her to have carried the ...
- 101
0
votes
3
answers
552
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Red and White Flower or purely Pink? Phenotype of a Flower Species with a Co-dominant Trait
As I understand it, co-dominance is when both genes in an allelomorphic pair produce both their effects equally on the organism in question whilst incomplete dominance applies to an instance where a ...
- 97