Questions tagged [drugs]
Drugs or pharmaceuticals are substances or combinations used to diagnose, cure, treat, or prevent disease.
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What antimicrobial can be readily synthesized in a school laboratory for a project on antimicrobial resistance? [closed]
I am currently a student studying at a high school hoping to do a project on antimicrobial compound synthesis to use in investigating antimicrobial resistance in E. coli strains. I am hoping to ...
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Why is Amphotericin B insoluble in water in the pH range that makes it zwitterionic?
Here is the structure of Amphotericin B, with its carboxylic acid and amine groups circled in red:
According to this source, The carboxylic acid group has a pKa of 5.5 and the amine group has a pKa ...
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Reason for adding TFAA in this synthesis pathway?
I have included a short part from a synthetic pathway from: https://synarchive.com/syn/112
$\ce{Mg3N2}$ reacts with $\ce{MeOH}$ to liberate $\ce{NH3}$ which I believe is used in nucleophilic ...
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Protein drug conjugate exercise
I am supposed to draw the structure of a derivative of the following structure which could be used to make a protein drug conjugate. And then I should draw the reaction for the protein modification.
...
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Translating from milligrams in the pill to Ki at the receptor
Many places (e.g. Wikipedia) report the action of a drug on the various receptors, transporters, ion channels, and the like in terms of the Ki(nM). (This is for drugs that act primarily through such ...
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How are cyclodextrins used to form inclusion complexes with drug molecules?
I'm talking about practical application. A cyclodextrin molecule hosts a drug molecule inside of it in order to increase solubility and stability of the drug.
But how do we make sure this inclusion ...
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How stable is Remdesivir when vial vacuum is broken and/or it is reconstituted with sterile water?
I was recently looking at how long can Remdesivir be stored in its different forms.
I came up across several articles provided by the FDA and Gilead Sciences and others.
What caught my eye was the ...
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Carbon 11 radiolabeled inhaled Beta-2 agonist or corticosteroids, is it possible?
Background
Positron emission tomography (PET) is a highly sensitive imaging modality that can provide in vivo quantitative information of biological processes at a biochemical level. PET relies upon ...
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About the acidity of Sultiame [closed]
Why is sulthiam base even hough sulfur can accept the electron by resonance from nitrogen
like carbonyl group do?
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API formulations - are excipients required
I have the following API's
Itraconazole, Ivermectin, Fenofibrate, Pyrvinium Pamoate, Sulfasalazine, Artesunate, All-Trans Retinoic Acid, Doxycycline, Atovaquone, Extremestane, Syrosingopine and ...
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How does Combinatorial Chemistry differ from Rational Drug Design?
I stumbled on Vertex Pharmaceuticals - Wikipedia.
It was one of the first biotech firms to use an explicit strategy of rational drug design rather than combinatorial chemistry.
Then I looked up ...
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What is the composition, function, and classification of “6-Thio-2-Deoxyguanosine” and “13-mer thio-phosphoramidate”? How do I learn more about them?
I am assigned the task of explaining a biomedical research paper, it is about telomere and telomerase , and it talks a lot about the molecule Thio-2-Deoxyguanosine , 13-mer thio-phosphoramidate and &...
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Synthesis cost of Fomepizole
Fomepizole is essential drug for methanol poisoning, I observed it cost too much like in 1000's of dollar for couple of ml.
Is cost due to patents, or due to synthesis cost,structure of molecule looks ...
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The importance of the cold chain in the food and the pharmaceutical industry
There are these everyday things that one should know as a scientist and especially as a chemist, but which never come to light in an academic curriculum — at least not in mine.
One such thing is the ...
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Why is heroin a more potent drug than morphine, despite having a similar structure?
The structures of heroin and morphine are quite similar, with heroin being formed by acetylation of morphine:
Why is heroin so much more potent than morphine, when their structures are so similar? ...
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