Questions tagged [drugs]
Drugs or pharmaceuticals are substances or combinations used to diagnose, cure, treat, or prevent disease.
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Is there a structured data source containing information on the World Health Organisation's Stability Testing Policies?
Hoping to automate some product testing guidance software, I've been attempting to find a (hopefully live, up-to-date) Database, Web-service, or other structured data source containing the ...
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Interference of Ca-EDTA with fluoride delivery in mouthwash
The goal of fluoride mouthwash is to deliver $\ce{F-}$ to the surface of the teeth to turn hydroxyapatite in the dental enamel into fluorapatite.
Typically sodium fluoride or stannous fluoride are ...
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degradation of sertraline
The picture above is a drug called Setraline. Suggest a likely mode of degradation of sertraline hydrochloride alone in aqueous solution, giving likely structures of the degradation products.
From my ...
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How are cyclodextrins used to form inclusion complexes with drug molecules?
I'm talking about practical application. A cyclodextrin molecule hosts a drug molecule inside of it in order to increase solubility and stability of the drug.
But how do we make sure this inclusion ...
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How stable is Remdesivir when vial vacuum is broken and/or it is reconstituted with sterile water?
I was recently looking at how long can Remdesivir be stored in its different forms.
I came up across several articles provided by the FDA and Gilead Sciences and others.
What caught my eye was the ...
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Bioinformatics tools for predicting synthetic reaction for identified drugs?
We are aware of many bioinformatics open source tools like AUTODOCK, Smina for drug discovery through structure based virtual screening.
I was wondering if there are validated bioinformatics tools ...
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Combining amphetamine and MAOIs
Could combining amphetamine and a (possibly selective) MAOI (MonoAmine Oxidase Inhibitor) increase the amphetamines potency without serious toxic side effects? If so by what factor, and would this be ...
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What are the specific disadvantages of using a bio-catalyst (called Lipolase) in the synthesis of the drug pregabalin?
I am studying the synthesis of a drug pregabalin, for which both chemical and bio-catalysts are used. Using a biocatalyst is way better than chemical route, as explained here. In fact, The invention ...
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How much hydrolysis will likely occur of the following bonds at pH 1-4 in the time period of 1-3 hours?
The bonds are: (I have given pictures of what I mean in case there's any ambiguity that I leave open in these questions. Also so that if you want to number the R groups you've got a head-start)
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Reduction of benzylic alcohol and halide using H2 and Pd
I am studying drug synthesis, and I found some examples that uses $\ce{H_2}$ and Pd/C or Pd/$\ce{BaSO_4}$ as catalytic hydrogenation reagents for reduction of alcohol or halide in benzylic position. ...
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Is there a formal definition of “identical” molecules?
I was reading about atropisomers and their impacts on drug design, and I started wondering whether we have a formal definition for identical molecules. Atropisomers are not the same molecules because ...
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Biocompatible positively charged functional groups on the pH range 5–9
In drugs and biomolecules, there are quite a few groups that are negatively charged around neutral pH (pH 5 to 9): carboxylates, sulfates, sulfonates, phosphates, phosphonates, tetrazoles, certain ...
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How to make Lithium medication from scratch
I take lithium carbonate as a medication. I was watching an "apocalypse-style" movie recently, which made me wonder how hard it would be to make my medication from scratch if I could no ...
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Do any pharmaceuticals increase in potency or toxicity over time?
Pursuing a question raised in these comments:
Are there any known pharmaceuticals that increase in potency or toxicity during storage, or over periods of months to years?
If not, what if we broaden ...
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Chemical interaction between Pterostilbene and Nicotinamide Riboside
Some supplement companies are putting a combinations of nicotinamide riboside and pterostilbene into the same capsule. Considering the stomach acid, water, body temperature, etc. I am wondering if ...
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