All Questions
12
questions
2
votes
0
answers
88
views
Reduction of benzylic alcohol and halide using H2 and Pd
I am studying drug synthesis, and I found some examples that uses $\ce{H_2}$ and Pd/C or Pd/$\ce{BaSO_4}$ as catalytic hydrogenation reagents for reduction of alcohol or halide in benzylic position. ...
- 1,101
1
vote
0
answers
52
views
Reason for adding TFAA in this synthesis pathway?
I have included a short part from a synthetic pathway from: https://synarchive.com/syn/112
$\ce{Mg3N2}$ reacts with $\ce{MeOH}$ to liberate $\ce{NH3}$ which I believe is used in nucleophilic ...
- 180
5
votes
1
answer
44
views
Carbon 11 radiolabeled inhaled Beta-2 agonist or corticosteroids, is it possible?
Background
Positron emission tomography (PET) is a highly sensitive imaging modality that can provide in vivo quantitative information of biological processes at a biochemical level. PET relies upon ...
- 51
1
vote
0
answers
58
views
Definition of throughput
I wonder what's the exact meaning of throughput in chemistry synthesis, eg. in organic synthesis or production of pharmaceutical products. For instance, what are their units? How are they measured?
I'...
- 64
-1
votes
1
answer
2k
views
When can you use the direct flame of a Bunsen burner, and when must you boil a beaker of water first?
I'd like to ask when you would do the following: use the direct Bunsen flame to heat a substance; place the substance in a test tube, which is placed in a beaker of water, then boil the water with the ...
- 27
3
votes
0
answers
60
views
Bioinformatics tools for predicting synthetic reaction for identified drugs?
We are aware of many bioinformatics open source tools like AUTODOCK, Smina for drug discovery through structure based virtual screening.
I was wondering if there are validated bioinformatics tools ...
- 110
10
votes
2
answers
877
views
Synthetic route to hydroxychloroquine
This drug hydroxychloroquine has become a new burning topic of discussion as a chemistry enthusiast:
I know that in an industrial preparation we need to account fpr a lot of factors like temperature, ...
- 320
7
votes
1
answer
192
views
Preparation of Effexor
I take venlafaxine (Effexor) as medication, and having wrapped up 2 semesters of Organic Chemistry I thought it might be fun to design a synthesis for it. A picture of venlafaxine:
I came up with the ...
- 397
3
votes
1
answer
357
views
Theoretical synthesis of dimetinden
I tried to find a way to synthesize Dimetinden (N,N-dimethyl-2-[3-(1-phenylethyl)-1H-inden-2-yl]ethan-1-amine) with an Indensynthesis
https://www.thieme-connect.com/products/ejournals/abstract/10....
- 379
10
votes
1
answer
271
views
How can I tell which parts of this example drug are necessary parts of its pharmacophore?
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This picture identifies a generic drug-enzyme complex taken from an exam script. There is no name given. One part of the exam question ...
- 641
3
votes
0
answers
1k
views
What are the specific disadvantages of using a bio-catalyst (called Lipolase) in the synthesis of the drug pregabalin?
I am studying the synthesis of a drug pregabalin, for which both chemical and bio-catalysts are used. Using a biocatalyst is way better than chemical route, as explained here. In fact, The invention ...
- 131
4
votes
1
answer
3k
views
Crystal meth in Breaking Bad [closed]
Can good quality crystal meth really be made as in Breaking Bad?
Can a pharmaceutical drug really be reverse-engineered?
