All Questions
13
questions
4
votes
2
answers
700
views
Acidity of metronidazole
Metronidazole has two $\mathrm{p}K_\mathrm{a}$ values: $2.57$ and $15.42.$ The basic group is the imidazole moiety. Does metronidazole have acidic groups?
- 49
-1
votes
1
answer
148
views
pH and degree of dissociation of drugs
I have a doubt, i hope not so stupid.
Suppose we consider a buffer solution of acetic acid/acetate at pH = pKa = 4.76 and we add aspirin (pKa = 3.5): given that the pH of the solution is higher than ...
- 127
1
vote
0
answers
328
views
Why is Amphotericin B insoluble in water in the pH range that makes it zwitterionic?
Here is the structure of Amphotericin B, with its carboxylic acid and amine groups circled in red:
According to this source, The carboxylic acid group has a pKa of 5.5 and the amine group has a pKa ...
- 1,410
2
votes
0
answers
31
views
About the acidity of Sultiame [closed]
Why is sulthiam base even hough sulfur can accept the electron by resonance from nitrogen
like carbonyl group do?
- 29
16
votes
2
answers
7k
views
Difference between Sildenafil and Sildenafil citrate
The data I found seems to show no difference between Sildenafil and Sildenafil citrate. But if they are the same things, why Pfizer use Sildenafil citrate instead of Sildenafil as their product Viagra?...
- 251
3
votes
3
answers
7k
views
Determine from pKa if acid or base
I'm studying medicine, not chemistry, but I hope you can help me anyway.
I just had to solve a question where it is given that the drug Propranolol has a $\text{p}K_{\text{a}}$ of 9.5 and the un-...
- 31
-1
votes
1
answer
3k
views
Turn Solution to hcl salt [closed]
I have a liquid mixture in a bottle containing different substances dissolved from their salt forms (i.e. lidocaine hydrochloride, anhydrous caffeine). These compounds are dissolved in distilled water....
- 1
2
votes
1
answer
932
views
In the graph provided, which of the substances is the most efficient in acting as an antacid?
If every dot represents the addition of 0.1 g of the respective base. I suppose that the best would be the one that reaches the highest pH, in the shortest time, for example Calcium Carbonate, but if ...
10
votes
2
answers
6k
views
Is ciprofloxacin acidic or basic?
I would expect an aqueous solution of ciprofloxacin to be basic for the following reasons:
The carboxyl group has pKa = 6.09 and the secondary amino group has pKa = 8.74. Because 8.74 is further from ...
- 470
4
votes
1
answer
899
views
How does the acidity of soft drinks not affect certain drugs, such as opiates? What about drugs and stomach acid?
Here's a very random introduction. I heard the term, "dirty Sprite" (it's some rap album/slang term) on a YouTube advertisement. I Googled "dirty Sprite", and it's apparently a recreational drug: ...
- 259
1
vote
1
answer
2k
views
Does DMT-Acetate become Polar in H2O, with added NaCl?
I'm extracting DMT (N,N-dimethyltryptamine) from Acacia confusa via acid/base. I extracted the DMT with $\ce{H2O}$ and acetic acid, converting it to DMT-acetate. Here, I used a non polar solvent, ...
- 21
5
votes
1
answer
2k
views
Why is acetylsalicylic acid still more acid than benzoic acid?
In this question, it is explained why salicylic acid is a stronger acid than benzoic acid. So, why acetylsalicylic acid (aspirin), whose conjugate base cannot hydrogen bond since there is no hydrogen, ...
- 357
21
votes
2
answers
21k
views
Why formulate drugs as HCl salts when HCl is in stomach acid?
I know there are issues of formulation and industrial processing that make it advantageous to produce many amine containing drugs as their salts rather than as freebases. And if giving the drug ...
- 219