Questions tagged [amines]
For questions about amines - organic compounds with a basic nitrogen with a lone pair, also occasionally referred to as derivatives of ammonia. Not to be confused with amides, for which the tag [carbonyl-compounds] is to be used.
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Conflict: Sandmeyer reaction and Gattermann reaction
So it is known that benzene diazonium chloride when reaction with cuprous(I) chloride would produce a chlorobenzene which is called Sandmeyer reaction.
Now for the same salt, if we react it with ...
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How to decide the correct numbering of aminocyclohexenol?
I'm self studying for a university admission exam. So I'm relying fully on online sources to study, but I often get confused because of differing methods. This is one such case:
According to this ...
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What does ‘S/A’ mean in SMARTS pattern when using Chemicalize to draw the chemical structure?
I am still new to the SMARTS annotation. I am wondering what does S/A’ mean on the bond labeling drawn with Chemicalize using SMARTS [!#1]c1n[cH]nc([!#1])c1[!#1]? ...
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What does ‘(A)’ mean in SMARTS pattern when using Chemicalize to draw the chemical structure?
I am not quite sure what ‘(A)’ could mean for the carbon atom when writing the SMARTS CCN(C)C using Chemicalize to draw the chemical structure below. Can anyone ...
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Why is this amine called this way?
I used a molecule drawing app to name the compound in the image, an amine. The name of the compound is 3-(aminomethyl)hexane according to the app. Shouldn't the name be 2-ethylpentan-1-amine?
The ...
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Frequency to induce nitrogen inversion
I would like to know how to compute the frequency at which nitrogen inversion happens in ammonia gas at STP. The activation energy for such process is 24.2 kJ/mol, therefore I thought that it is ...
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Which is more nucleophilic: acetamide or aniline?
Which compound will be more nucleophilic, knowing that the electron pair will be more delocalized in the ring for aniline? On the contrary, for the acetamide the electron pair will only be delocalized ...
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Iminium formation rate between formaldehyde and secondary amine
Given the significantly more favored hydrate of formaldehyde in the presence of water under neutral conditions, can we say that this is the slow step in iminium formation? Would removing water/working ...
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How to identify an organic base?
According to the answer key, trimethylamine (iii) and ethanolamine (iv) are considered organic bases, whereas ammonium (i) and acrylamide (ii) are not:
From my understanding, an organic base has an ...
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Regarding Hinsberg reagent, potassium salt of primary amine soluble in base become insoluble after acidification?
Distinguish between ethylamine, diethylamine and triethylamine by using Hinsberg's reagent?
Ans. This reaction is useful for the distinction of primary, secondary and tertiary amines.
(i) Primary ...
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Why is the lysine side chain more basic?
As per PubChem: $pK_1 = 2.18$; $pK_2 = 8.95$; $pK_3 = 10.53$ at 38 °C, indicating that the side chain amino group is deprotonated at a higher pH, indicating it is more basic. I tried to justify this ...
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Inductive Effect (R-NH3+ and R-NH2)
Textbooks I've read state that R-NH3+ has exhibits a greater -I inductive effect than R-NH2 does.
However, I've also read in places that the + charge in R-NH3+ only represents a formal charge and has ...
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Nomenclature of C6H5CO-O-NH2
How to name the following compound using IUPAC nomenclature? I found benzyl carbamate to be very close to my structure, but couldn't find an exact compound online which matches mine.
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Basicity of pyridine and 2,6-di-tert-butylpyridine
Among pyridine and 2,6-di-tert-butylpyridine, which one would be more basic?
My guess was that since two bulky groups are substituted at ortho position in the latter, it will experience steric ...
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Reason behind benzylamine being a primary amine
Benzylamine is a primary amine. Now a primary amine has the general formula R-NH₂ where R is an alkyl or aryl group. So here R will be equal to $\ce{C6H5CH2}$. But $\ce{C6H5CH2}$ is neither an alkyl ...
