All Questions
Tagged with drugs solubility
5
questions
1
vote
0
answers
328
views
Why is Amphotericin B insoluble in water in the pH range that makes it zwitterionic?
Here is the structure of Amphotericin B, with its carboxylic acid and amine groups circled in red:
According to this source, The carboxylic acid group has a pKa of 5.5 and the amine group has a pKa ...
- 1,410
3
votes
0
answers
58
views
How are cyclodextrins used to form inclusion complexes with drug molecules?
I'm talking about practical application. A cyclodextrin molecule hosts a drug molecule inside of it in order to increase solubility and stability of the drug.
But how do we make sure this inclusion ...
- 47
-1
votes
1
answer
825
views
What is the solubility of quinine suphate in 98% ethanol?
I have a result from an experiment that really bothers me, yet I found no sources online that can explain the situation.
While quinine is relatively soluble in ethanol because they are both non-...
-1
votes
1
answer
261
views
Effect on solubility by dissolution of other substance (no common ion)
In one of our recent classes on mass and momentum transfer, we studied qualitatively how blood drug concentrations vary after consuming a tablet containing that drug.
We considered the following:
...
- 1,526
14
votes
3
answers
1k
views
Is it possible to make a drug that liquefies heart plaque to treat heart disease?
Is it possible to make a drug that liquefies heart plaque to treat heart disease without damaging other parts of the body? If so, would the liquefied plaque be eliminated as regular fluid is through ...
- 377