All Questions
Tagged with amines biochemistry
8
questions
4
votes
1
answer
337
views
What are the best conditions for coupling small molecules with EDC?
I want to couple a DNA oligo containing an amino group with another small molecule possessing a carboxyl group.
I found protocols for EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) coupling of ...
- 201
0
votes
1
answer
198
views
Why isn't the aniline hydrolysed in Sanger's protein sequencing method?
Recently I was reading about identifying N-terminal amino acid residues using Sanger's reagent (1-fluoro-2,4-dinitrobenzene). The following image showing the reaction is taken fro Wikimedia Commons:
...
2
votes
1
answer
582
views
Ritalin/Concerta/Methylphenidate is an amphetamine?
FIDE (the governing body of international chess competition) says here:
The most relevant banned substances for chess are:
• Amphetamines – e.g. Adderall, Ritalin
(...)
Image:
I think either ...
- 291
2
votes
1
answer
123
views
How to predict amine donor in biochemical reactions (whether glutamine or aspartate)?
In biochemical reactions amine $(\ce{-NH2})$ transfer is done in multiple pathways (e.g. urea cycle, purine biosynthesis etc.).
In many of the situations glutamine donates amine group (e.g. xanthosine ...
- 121
2
votes
1
answer
5k
views
Histidine vs Lysine
Among the amino acids, histidine and lysine, which is more basic?
And why?
I tried protonating and checking electronic effects but couldn't reach a satisfactory conclusion.
- 776
0
votes
1
answer
611
views
Why aren't the amine groups in the nucleic acid bases protonated?
Nucleobases G, C and A carry an amine group ($\ce{-NH2}$). In amino acids, the amine groups are considered protonated at physiological pH. Why isn't it the case for the amine groups of nucleobases?
I ...
- 597
6
votes
1
answer
1k
views
Regarding the mechanism for biological activity of tyramine, amphetamine and ephedrine
Graham Patrick explains the mechanism for the activity of tyramine, amphetamine and ephedrine in his book Introduction to Medicinal Chemistry as follows:
Some amines such as tyramine , amphetamine ...
- 6,233
2
votes
1
answer
1k
views
Why is the deprotonated form of dopamine more reactive than the protonated/neutral form of dopamine?
See this (from the Wikipedia article on dopamine):
Dopamine, like most amines, is an organic base. At neutral or acidic
pH levels it is generally protonated. The protonated form is highly
water-...
- 697