All Questions
5
questions
3
votes
1
answer
54
views
Will ethyl 2-amino-1H-imidazole-5-carboxylate undergo ester aminlysos with the primary amines of bPEI efficiently in methanol?
I was about to set up the following reaction, but before I do, I wanted to see if anyone has some suggestions or thinks this will not work:
24mmol Nboc protected ethyl 2-amino-1H-imidazole-5-...
- 137
1
vote
0
answers
1k
views
While treating 4-aminophenol with acetic anhydride why does the reaction stop at Paracetamol and does not undergo esterification with acetic acid?
This needs a little background so I will be showing you a question from one of my Organic Chemistry problem books:-
Now, the book shows the answer as Option (c) which is Paracetamol.
I tried to work ...
- 19
2
votes
1
answer
3k
views
Direct conversion of amides to esters
Rarely does the literature describe the synthesis of esters from amides. I understand that amides are a relatively unreactive functional group but they can easily be hydrolysed to give carboxylic ...
- 21
1
vote
2
answers
303
views
Formation of Lactone from 5-amino-decanoic acid?
As expressed in the title, I am trying to figure out how to form a lactone from 5-amino-decanoic acid. The thing that comes to my mind as a start is the attachment of the amino group ($\ce{NH2}$) to ...
- 153
11
votes
1
answer
22k
views
Mechanism for formation of amide by reaction of amine with ester
This is the mechanism given in my lecture handout:
I have a problem with the third species along. Surely the negatively charged oxygen would protonate before the other oxygen would. Also, why does ...
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