The CHAIN project aims to coordinate advanced e-infrastructures between Africa and Europe for access by research communities. It consolidates the state of e-infrastructures, models cooperation, and supports intercontinental virtual research communities. In Africa, South Africa has the most developed e-infrastructure through SAGrid and partnerships like AfricaGrid are working to integrate resources across the continent and regions like North Africa, Middle East and provide support services. CHAIN will help prepare African initiatives for interoperable participation in global e-infrastructures.