Questions tagged [synthesis]
Synthesis is a purposeful execution of chemical reactions to obtain the desired product. Applies to long and complex natural product syntheses as much as to short one or two-step syntheses. This also covers synthetic problem sets and retrosynthetic analyses.
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Protecting Thiol group in presence of alcohol
What protecting group can I use that will protect the thiol in the presence of an alcohol? Is there a set of conditions, or a group that I can use that is selective to the thiol over the alcohol?
I am ...
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Is it possible to prevent elimination during Diels Alder reactions using Danishevsky's diene (or variants)?
Are there examples of keeping the methoxy group and then using it to perhaps do radical chemistry without eliminating to the enone?
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Finding chromium
If I were to go back in time to pre-industrial Earth, and I wanted to make stainless steel, would there be a way to find chromium and/or chromite? It doesn't matter what chemical form the chromium ...
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How to synthesize lanthanum(III) chloride & Cerium(III) chloride from their oxides?
Interested in obtaining anhydrous lanthanum/cerium chlorides
$\ce{La2O3}$ / $\ce{СeO2}$ in a flow of carbon tetrachloride at 500 degrees
$\ce{La2O3}$ / $\ce{CeO2}$ with ammonium chloride when heated (...
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What is the best way to deprotonate a methyl group?
I am attempting to deprotonate the methyl group on 2-methylbenzo[d]thiazol-6-ol (hydroxyl group is protected with a silyl group) in order to attach a phosphate group in the form of diethyl ...
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Why will changing the solvent crack the column for column chromatography?
When we perform column chromatography with silica to purify the reaction crude product, we sometimes need to change the solvent system to better extract our target product.
For example, changing from ...
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What are the reactions between Zinc acetate dihydrate and Methoxyethanol? [closed]
I am synthesizing a sol-gel solution with Zinc acetate dihydrate + Methoxyethanol and ethanolamine as stabilizer, and I wonder what are the reactions that are taking place in the process. Could you ...
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How is NADH or NADPH produced in industrial chemical synsthesis?
I am trying to find out how NADH or NADPH are produced in bulk. These molecules are very important biologically, however, they are also sold as chemical reagents and produced in large quantities. How ...
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Cause and Prevention of Palladium Mirror in Stille Coupling
I am conducting some monomer and polymer syntheses using Stille coupling or other palladium-based coupling. I usually use the combination of $\ce{Pd_2(dba)_3}$ and $\ce{P(o-tol)_3}$ in Stille coupling,...
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How do you synthesize 1-fluoro-4-(tribromomethyl)benzene from toluene
I got this question from an o-chem II exam which kinda puzzles me a bit
My proposed path is:
which doesn't seem to be correct. Is there any other way within the knowledge of o-chem I & II?
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Why is the sp3-sp3 reductive elimination between the R1 and norbornene in the Catellani Cycle ''not favorable''?
I have recently started reading a book about C-H activation and I cannot figure out why in the Catellani reaction cycle the R1-norbornene reductive elimination side reaction which can be a major issue ...
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Synthesis of a Substituted Indane
From the starting reactants given as the sole carbon source:
We need to synthesis the following compound (we can use any inorganic reagents).
Here is what I tried so far, but I don't think it looks &...
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synthetic procedure for 1,3,4 thiadiazole from acylhydrazide [closed]
I wanted to synthesize 1,3,4 thiadiazole-2- thiol substituted to benzoic acid the reaction has to happen in such a way that the "acid hydrazide" group of benzoic acid hydrazide has to ...
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Halogenation of organic acid derivatives
Chloropicrin can be produced through the reaction of sodium hypochlorite with nitromethane. On the surface, this seems to me to proceed through a mechanism analogous to the haloform reaction, with one ...
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Can we use potassium hydroxide to decarboxylate potassium benzoate to benzene?
I know the famous reaction:
I was thinking of extension of this reaction to other salts of Benzoic Acids such as:
$$\ce{Potassium Benzoate + KOH ->[CaO,Δ] Benzene + K2CO3}$$
Is this reaction ...
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