All Questions
11
questions
0
votes
0
answers
78
views
Steglich Esterification in Alkyl Gallates
Based on my research (reading some articles), some alkyl gallate syntheses used Steglich esterification instead of the usual esterification (Fischer esterification). The reason why Steglich ...
- 155
0
votes
1
answer
128
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Is formation of cyclic carbonate from trimethyl orthoformate and vicinal aromatic 1,2-diol possible? [closed]
Hello, my question is, "is it possible cyclic carbonate formation between trimethyl orthoformate and vicinal aromatic 1,2-diol"
8
votes
0
answers
91
views
Mechanism of Hypervalent Iodine Phenolic Coupling
I need some help understanding the hypervalent iodine phenolic coupling reaction taking place in this synthesis of morphine, the reaction uses $\ce{PhI(OAc)2}$ as the hypervalent reagent and ...
- 147
1
vote
1
answer
2k
views
Can we convert phenol to para-nitrophenol via nitrosophenol?
Our class 12 text book says that if we treat phenol with mixture of concentrated $\ce {HNO3}$ and $\ce{H_2SO_4}$, instead of nitration, the ring is oxidized to quinone.
So, the book proposes that we ...
7
votes
1
answer
3k
views
Evaluation of a synthesis from aspirin to paracetamol from this Nile Red video
Recently the YouTube chemist Nile Red performed an interesting conversion from aspirin to paracetamol Aspirin to Acetaminophen - Part 1 of 6: Extracting Aspirin from Pills using the following steps:
...
- 586
6
votes
2
answers
2k
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Suggestion for a Synthesis of Paracetamol — plausible?
I have seen a number of different plausible syntheses for paracetamol but they suffer from problems such poor regioselectivity of aromatic substitution (usually when nitrating phenol getting a mixture ...
- 9,802
7
votes
1
answer
3k
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Synthesis of 2-methyl-4-nitrophenol from benzene?
Benzene first reacts with the reagents $\ce{CH3Cl/AlCl3}$, to attach a methyl ($\ce{CH3}$) group to the benzene ring.
Then I suggested reacting with $\ce{OH-}$. Because the methyl group is an ...
5
votes
2
answers
1k
views
How to esterify phenol with oxalic acid?
Is it possible to fully esterify phenol with oxalic acid in order to get diphenyl oxalate? What catalyst should I use and is the synthesis possible to perform at home with hobby equipment?
- 153
6
votes
4
answers
8k
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How are phenols made?
What is the equation and conditions for the synthesis of phenols? Would it work if we added $\ce{NaOH}$ to benzene and then refluxed?
3
votes
1
answer
2k
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Phenol protection
Would an acceptable way to protect a phenolic alcohol be through a Williamson ether synthesis? As in:
1) Deprotonating phenol with sodium hydroxide.
2) Addition of methyl iodide.
3) Deprotection ...
- 19k
12
votes
3
answers
8k
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How can we synthesize para-nitrophenol
During nitration of phenol, both para- and ortho-nitrophenols will be formed.
Is there any way in which we can synthesize para-nitrophenol only?
- 2,758