All Questions
Tagged with synthesis experimental-chemistry
86
questions
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How to avoid side reactions when making boronic esters (Homocoupling, Hydrogen specie)?
I have been working with suzuki couplings using substituted naphtalenes (typically 2-bromo-7-R-naphtalene) for a while now, and making the boronic specie is always a pain.
I can't make the boronic ...
3
votes
1
answer
180
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Will a nitro aryl resist an halogen exchange using nBuLi?
I would like to boronate 2-bromo-6-nitro-naphtalene using nBuLi and quenching with 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. Since there is no alpha proton to the nitro, and that the nitro ...
1
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0
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31
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After adding the electrophile (BOMe3) in an halogen exchange (nBuLi) reaction, why do we leave the reaction stir overnight?
Very basic question.
In all the procedures for halogen exchange reactions reported using boronic compounds, the reaction is left to run ON at room temperature after addition of the boronic specie.
In ...
5
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2
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197
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Synthesizing Cyclotetrazane from Hydrazine and Diazene?
Could cyclotetrazane — a compound with nitrogen atoms arranged in a square configuration — be synthesized? A hydrogen atom would be bonded to each vertex (nitrogen atom):
Could cyclotetrazane be made ...
user145192
4
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0
answers
50
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Why cool a reaction down when adding reagents if you're only going to reflux subsequently?
I've seen several procedures using thionyl chloride (SOCl2) to make an ester, where the first step is to add the thionyl chloride to the reagent/solvent on ice or subzero temperature, followed ...
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7
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2
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642
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Question about the differences of white and grey NaH properties
We are having some problems with the next reaction in our lab. As you can see, is the sulfonylation of an indole in which we use NaH (60% dispersion in mineral oil) as a base. This reaction goes with ...
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2
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2
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257
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Should I remove inhibitor from methyl acrylate?
I need to run multiple aza-Michael additions of methyl acrylate with various amines (dimethylamine, benzylamine, phenylethylamine, aniline, etc.) in order to get the bis-ester. I was wondering if the ...
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1
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0
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149
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Why did this synthesis of Aspirin fail?
I tried to synthesize acetylsalicylic acid(aspirin) by the method below. However, I definitely failed and got something unknown.
The method used was:
Add 2.5 g of salicylic acid(about 2494 mg), 3.0 ...
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2
votes
1
answer
45
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Production SnO2 nanoparticles through chemical co-precipitation method: chemical equation of the reaction
In this paper, the production of $\ce{SnO2}$ nanoparticles through the chemical co-precipiation method is described using $\ce{SnCl2·2H2O}$ as a precursor. According to their experimental section,
$\...
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2
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2
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379
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How do I synthesize salicylic acid?
I'm looking to synthesize salicylic acid in my school laboratory for an investigatory project. The Kolbe's reaction looks promising:
Any suggestions on where to get the $\ce{CO2}$ from?
Will the ...
0
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1
answer
285
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What are the reactions between Zinc acetate dihydrate and Methoxyethanol? [closed]
I am synthesizing a sol-gel solution with Zinc acetate dihydrate + Methoxyethanol and ethanolamine as stabilizer, and I wonder what are the reactions that are taking place in the process. Could you ...
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-3
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1
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49
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synthetic procedure for 1,3,4 thiadiazole from acylhydrazide [closed]
I wanted to synthesize 1,3,4 thiadiazole-2- thiol substituted to benzoic acid the reaction has to happen in such a way that the "acid hydrazide" group of benzoic acid hydrazide has to ...
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4
votes
1
answer
768
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Does germanium(IV) chloride have to be handled under inert atmosphere?
I am finding conflicting information on the proper handling of germanium(IV) chloride. Is the liquid air/moisture sensitive? Does $\ce{GeCl4}$ have to be handled in a glove box?
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0
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77
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Erythritol oxidation using acidified KMnO4
I have recently experimented with erythritol oxidation my primary aim was to make glyoxal. However regarding the nature and structure of erythritol several other side-products were also observed one ...
0
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1
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40
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Is there any calcium carbonate analogue drawing carbon from dry air?
Is there a nonliving (wood does not count) substance or process that accretes a solid material by withdrawing carbon from the air, in a manner analogous to calcium carbonate being accreted from ...
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