Questions tagged [synthesis]
Synthesis is a purposeful execution of chemical reactions to obtain the desired product. Applies to long and complex natural product syntheses as much as to short one or two-step syntheses. This also covers synthetic problem sets and retrosynthetic analyses.
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Selective formation of enolates
I saw the following reaction on Modern methods of Organic Synthesis by Carruthers. The reaction is about the selective alkylation of trimethylsilyl enolates, and is shown below.
However, I have some ...
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Amidine synthesis from nitrile and dimethylamine using n-Buli as a base
I am making LiNMe2 using n-Buli (5.5 equiv.) and dimethylamine (5.0 equiv), -15 ºC, dry THF and under nitrogen atmosphere.
I have been doing the reaction and I can observe conversion of starting ...
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Can any compound form into an amorphous solid?
I am curious whether it is possible or not to make any solution of a specific compound into a crystal lattice or into an amorphous solid? I know that crystals form under specific conditions but seem ...
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TMSiBr and Oxalylchloride for ester cleavage
I am wondering what is the advantage of using TMSiBr do perform an ester cleavage in comparison to perform chlorination first for example with oxalylchloride or thionylchloride and than add water?
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Esterification of phosphonic acid chloride is working with isoprenol but not with prenol
I am performing an esterfication reaction between an activated phosphonic acid (chloride) and a series of alcohols. Until now, I was not able to make the reaction work with prenol, while isoprenol is ...
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Reaction of eugenol with concentrated hydrobromic acid in the presence of gaseous hydrogen bromide [closed]
DISCLAIMER: I am not using any of this information to commit a crime, my university has a license from the relevant authorities to investigate clandestine chemical procedures.
We are investigating an ...
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Avoid triethylphosphate as a side product during P-C-P coupling reaction with diethylchlorophosphate with LDA
I have a reaction in which I perform a deprotonation of an acidic proton at a phosphate and later do a P-C-P coupling. The coupling partner is diethylchlorophosphate. Deprotonation is performed with ...
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Specific question about the total synthesis of B-12
In the process of synthesizing B-12, Woodward & Co. produce an intermediate thioether they refer to as Type I. "Type I because we found early in working with these substances that they were ...
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Are these reactions in synthesis of melamine correct?
I found the Wikipedia article for melamine to be incorrect in "synthesis and reaction" section; so I decided to edit it. But on the other hand I'm not sure my assumption to be correct that ...
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Alternative synthesis for LK-99 proposed room-temperature superconductor
This is probably not the best place to post this, but I'm posting in case it might reach the right people who could give this a try.
The current synthesis for the proposed LK-99 superconductor is a ...
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Production SnO2 nanoparticles through chemical co-precipitation method: chemical equation of the reaction
In this paper, the production of $\ce{SnO2}$ nanoparticles through the chemical co-precipiation method is described using $\ce{SnCl2·2H2O}$ as a precursor. According to their experimental section,
$\...
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How do I synthesize salicylic acid?
I'm looking to synthesize salicylic acid in my school laboratory for an investigatory project. The Kolbe's reaction looks promising:
Any suggestions on where to get the $\ce{CO2}$ from?
Will the ...
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Magnesium chloride to citrate conversion (reaction/synthesis)
How would one prepare magnesium citrate from magnesium chloride and citric acid? Will it work if I just heat a mixture of magnesium chloride and citric acid in water? I'd expect HCl to vaporize off.
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Color change when heating organic compound
I did just attend a lab class where I should synthesize 3,6-dibromo- N-propylcarbazole from N-propylcarbazole by bromination. Once, the bromination was over the color of the reaction content was ...
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How does the synthesis of [18]annulene proceed stepwise?
Finding good literature on the synthesis of [18]annulene is challenging, as most sources are well old and quite archaic, so I was hoping some explanation in regard to the mechanism of synthesis.
My ...
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