Questions tagged [synthesis]
Synthesis is a purposeful execution of chemical reactions to obtain the desired product. Applies to long and complex natural product syntheses as much as to short one or two-step syntheses. This also covers synthetic problem sets and retrosynthetic analyses.
849
questions
4
votes
0
answers
114
views
Hydrolyse a fluorophosphonic compound / Which protective group strategy can I use for phosphonate esters to access the free acid after a reaction?
I have a synthetic problem in my PhD thesis, in which I synthesize a phosphonate ester.
To be more precise, it is a phosphonofluoridic compound. In my specific case, the fluorine attached to the ...
- 799
0
votes
0
answers
78
views
Steglich Esterification in Alkyl Gallates
Based on my research (reading some articles), some alkyl gallate syntheses used Steglich esterification instead of the usual esterification (Fischer esterification). The reason why Steglich ...
- 155
2
votes
2
answers
257
views
Should I remove inhibitor from methyl acrylate?
I need to run multiple aza-Michael additions of methyl acrylate with various amines (dimethylamine, benzylamine, phenylethylamine, aniline, etc.) in order to get the bis-ester. I was wondering if the ...
- 21
0
votes
0
answers
39
views
Breakdown of addition polymers
We know that condensation polymers can be broken down by hydrolysis with the elimination of small water molecules.
Then what about addition polymers? How can they be broken down into their monomers?
I ...
- 557
-3
votes
1
answer
75
views
Synthesizing "Methyl 2-(2-oxopyrrolidin-1-yl)-2-phenylacetate" [closed]
I am a chemistry student, here I mapped out the steps one might take to synthesize Methyl2-(2-oxopyrrolidin-1-yl)-2-phenylacetate, a piracetam dirivitive. Please add any steps I might be missing and ...
- 1
0
votes
0
answers
50
views
Advise on performance vs cost of the Berkland-Eyde Process for direct synthesis of Nitric Acid from atrmospheric air
I am new to chemistry, having gone down an electronics route in my career, so I decided to pick up where my 'O' levels ended (many years ago) and make a better understanding of the topic a sort of ...
- 101
0
votes
0
answers
54
views
Methanisation in the Haber Porcess
I've been reading up on the Haber process lately.
In one such industrial case of ammonia synthesis, hydrogen is created through steam reforming, which creates some carbon monoxide. As the reaction ...
- 97
2
votes
0
answers
82
views
What is the product and mechanism of reducing a cyclohexanone derrivative with LAH?
I've been trying to figure out the product and mechanism of the reaction pictured below for a while now:
I'm fairly sure that the first step is the reduction of the ketone by LAH, which results in a ...
- 29
3
votes
0
answers
119
views
Hydrolyse Phosphonate diester to free phosphonic acid under relatively mild conditions?
I want to hydrolyse a phosphonic acid diethylester to the corresponding free phosphonic acid. In the literature, it is described, that usually strongly basic or acidic conditions are utilized to ...
- 799
1
vote
0
answers
149
views
Why did this synthesis of Aspirin fail?
I tried to synthesize acetylsalicylic acid(aspirin) by the method below. However, I definitely failed and got something unknown.
The method used was:
Add 2.5 g of salicylic acid(about 2494 mg), 3.0 ...
- 11
-3
votes
1
answer
200
views
Production of sulphuric acid
To my knowledge, sulphuric acid is produced by complex industrial processes like contact process.
The following structure shows a sulphate ion.
I wonder why sulphuric acid cannot be produced through ...
- 557
2
votes
0
answers
89
views
Reduction of benzylic alcohol and halide using H2 and Pd
I am studying drug synthesis, and I found some examples that uses $\ce{H_2}$ and Pd/C or Pd/$\ce{BaSO_4}$ as catalytic hydrogenation reagents for reduction of alcohol or halide in benzylic position. ...
- 1,101
2
votes
0
answers
50
views
Degradation of 4-MeO-Tetrahydrocarbazole
I recently synthesized 4-Methoxy-Tetrahydroxarbazole from 4-MeO-Phenylhydrazine and Cyclohexanone. The product had a off-white color directly after synthesis but was brown after standing over night at ...
- 31
1
vote
0
answers
59
views
Synthesis of 1-ethylcyclohexane-1,2-diol from cyclohexylethene
Here's my synthesis:
HBr
NaEtO
OsO4/NMO
But the problem is that for step 2, there are 3 possible alkene locations, with all of them having 3 substituents, so I would have all 3 forming (although 2 ...
- 11
0
votes
0
answers
72
views
Find the missing chemical structures in the reaction sequence
I came across the following question, where a set of reagents are used, starting from a carbohydrate derivative.
I understand that this is some total synthesis reaction, but I cannot find which one.
...
- 371