User raptorlane - Chemistry Stack Exchange

4 votes

0 answers

114 views

Hydrolyse a fluorophosphonic compound / Which protective group strategy can I use for phosphonate esters to access the free acid after a reaction?

asked Feb 3 at 19:12

4 votes

2 answers

234 views

Can glycerol slow down the kinetics of an inhibitor going to a binding pocket of a target enzyme?

asked Feb 11 at 12:56

4 votes

0 answers

270 views

Exchange of Fluorine to Oxygen for Fluorophosphonic acid by silylating agents or other methods?

asked Mar 22 at 14:36

4 votes

1 answer

106 views

Compatibility of DCM/CCl3 with sodium hydride

asked Jun 11 at 19:46

3 votes

1 answer

163 views

Are there LCMS compatible buffer systems available for the high pH range 12-14?

asked Nov 4, 2023 at 10:48

3 votes

0 answers

119 views

Hydrolyse Phosphonate diester to free phosphonic acid under relatively mild conditions?

asked Nov 11, 2023 at 14:41

2 votes

1 answer

88 views

What can I do if a peptide won't go in solution in a biological assay?

asked Jan 7 at 12:46

2 votes

1 answer

128 views

Calculate IC50 from fluorescence kinetic

asked Jan 15 at 1:04

2 votes

0 answers

37 views

Synthesize pivaloyloxymethyl ester, but with a substrate that is a terrible nucleophile

asked Mar 29 at 17:08

2 votes

0 answers

35 views

Electrophilic fluorination power: selectfluor vs NFSI

asked Apr 12 at 21:22

2 votes

0 answers

32 views

TMSBr and 2,4,6 Collidin in Acetonitrile leads to white precipitate

asked Mar 19 at 20:23

2 votes

1 answer

60 views

(Di)chlorination of phosphonic acid ester

asked Jun 14 at 18:50

2 votes

0 answers

56 views

Clean di protection of phosphonic acid dichloride with a suitable protection group with clean deprotection

asked Jul 10 at 9:13

2 votes

0 answers

69 views

Stability of n-Dodecyl-beta-D-maltoside in buffer solutions for assay experiments

asked Feb 11 at 11:38

1 vote

1 answer

125 views

Making an UV inactive salt UV active during purification of charged anion with HILIC purification?

asked Feb 4 at 15:02

1 vote

0 answers

51 views

Transesterfication: Which is a suitable acid that does not contaminate the polar product?

asked Apr 5, 2023 at 6:39

1 vote

0 answers

146 views

Are there TLC stains for organo fluor compounds or anorg. fluoride that are useful for selecting the product containing fractions post purification

asked Apr 6, 2023 at 20:28

1 vote

0 answers

299 views

What is a suitable process to eliminate an excess of pyridine from an aqueous solution?

asked Apr 7, 2023 at 7:18

1 vote

0 answers

33 views

Avoid triethylphosphate as a side product during P-C-P coupling reaction with diethylchlorophosphate with LDA

asked Sep 12, 2023 at 8:04

1 vote

0 answers

45 views

Esterification of phosphonic acid chloride is working with isoprenol but not with prenol

asked Sep 24, 2023 at 11:02

1 vote

0 answers

56 views

TMSiBr and Oxalylchloride for ester cleavage

asked Sep 24, 2023 at 13:44

0 votes

0 answers

62 views

Elegant and fast way without chromatography to remove fluoride ions from water phase without contamination of the polar water soluble product?

asked Apr 5, 2023 at 14:20

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22 Questions

Hydrolyse a fluorophosphonic compound / Which protective group strategy can I use for phosphonate esters to access the free acid after a reaction?

Can glycerol slow down the kinetics of an inhibitor going to a binding pocket of a target enzyme?

Exchange of Fluorine to Oxygen for Fluorophosphonic acid by silylating agents or other methods?

Compatibility of DCM/CCl3 with sodium hydride

Are there LCMS compatible buffer systems available for the high pH range 12-14?

Hydrolyse Phosphonate diester to free phosphonic acid under relatively mild conditions?

What can I do if a peptide won't go in solution in a biological assay?

Calculate IC50 from fluorescence kinetic

Synthesize pivaloyloxymethyl ester, but with a substrate that is a terrible nucleophile

Electrophilic fluorination power: selectfluor vs NFSI

TMSBr and 2,4,6 Collidin in Acetonitrile leads to white precipitate

(Di)chlorination of phosphonic acid ester

Clean di protection of phosphonic acid dichloride with a suitable protection group with clean deprotection

Stability of n-Dodecyl-beta-D-maltoside in buffer solutions for assay experiments

Making an UV inactive salt UV active during purification of charged anion with HILIC purification?

Transesterfication: Which is a suitable acid that does not contaminate the polar product?

Are there TLC stains for organo fluor compounds or anorg. fluoride that are useful for selecting the product containing fractions post purification

What is a suitable process to eliminate an excess of pyridine from an aqueous solution?

Avoid triethylphosphate as a side product during P-C-P coupling reaction with diethylchlorophosphate with LDA

Esterification of phosphonic acid chloride is working with isoprenol but not with prenol

TMSiBr and Oxalylchloride for ester cleavage

Elegant and fast way without chromatography to remove fluoride ions from water phase without contamination of the polar water soluble product?