Thomas Koblizek

❓ Have you already planned your trip to Dresden? ➡️ If not, then take a look at the website, where we have compiled all the important information for you: https://lnkd.in/eq59ddaQ #HUPO2024 #Proteomics #humanproteomics #clinicalproteomics #Microbiome #cellbiology #Bioinformatics

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‼️𝙉𝙚𝙬 𝙋𝙖𝙥𝙚𝙧 𝙊𝙪𝙩 ‼️ Direct measurement can make a huge difference in real-time drug testing. In this recent paper, #SICRIT was utilized for direct screening of 𝗦𝗲𝗹𝗲𝗰𝘁𝗶𝘃𝗲 𝗔𝗻𝗱𝗿𝗼𝗴𝗲𝗻 𝗥𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗠𝗼𝗱𝘂𝗹𝗮𝘁𝗼𝗿𝘀, which are commonly abused in professional and semi-professional sports. 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀: 🟢 Two ambient ionization mass spectrometry techniques were used to analyze seized samples of illegal SARM formulations 🟢 Ambient mass spectrometry results were validated by comparing with newly developed LC-UV-MS/MS method 🟢 The results shows that Desorption Atmospheric Pressure Photoionization and Dielectric Barrier Discharge Ionization can be used to quickly screen SARM compounds 🟢 Set of criteria was established for positive identification of illegal SARM compounds by ambient MS #newpaper #drugtesting #directscreening #directms #DBDI #rethinkinglabs https://lnkd.in/dracfuJ5

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🔬 Breakthrough in DNA repair mechanism elucidated Through Cryo-Electron Microscopy! 🔬 Researchers at The Julius Maximilians University of Würzburg(JMU) have made a significant discovery in understanding how our bodies repair DNA damage. Led by biochemist Caroline Kisker and chemist Claudia Höbartner, the team has elucidated the mechanism by which the XPD protein detects severe DNA damage and orchestrates its repair. This groundbreaking study is published in Nature Structural & Molecular Biology. 📚 Using cryo-electron microscopy, the team achieved a 3D reconstruction with an impressive 3.1 Å resolution. The XPD protein (green) and accessory factor p44 (cyan) were observed interacting with damaged DNA (orange) at the atomic level. 🧬✨ Key Highlights: 🔍 XPD Protein's Role: Acts like a "sniffer dog" in the nucleotide excision repair (NER) system, detecting and repairing DNA damage, crucial in preventing conditions like skin cancer. 🧩 Interstrand Crosslinking: The study focused on one of the most severe forms of DNA damage, caused by environmental toxins and industrial chemicals, which can lead to cancer. 🏗️ Mechanism Unveiled: The team analyzed how XPD unwinds the DNA double helix to expose defective sites, creating a model for damage detection and removal. 💡 Implications for Cancer Treatment: The findings lay the groundwork for new cancer therapies by potentially weakening repair mechanisms in cancer cells to enhance drug efficacy. Next Steps: The research team plans to further investigate how XPD detects various other types of DNA damage, paving the way for even more breakthroughs in understanding and treating genetic diseases. 🚀 Kudos to the brilliant team at JMU for this remarkable advancement in structural biology! 🌟👏 #DNARepair #CryoEM #StructuralBiology #CancerResearch #Biochemistry #ScientificBreakthrough #Genetics #HealthcareInnovation #Research #JMU #NatureStructuralMolecularBiology

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New expert interview feat. Dr. Oliver Gutmann from Roche Diagnostics 🆕 2/3 of most diagnostics testing issues in laboratories have root causes before the sample even reaches the laboratory. At the same time, labs are made responsible to resolve all issues and deliver test results of high quality. 👨‍🔬 A big challenge for laboratories, which are also already struggling with a considerable shortage of skilled workers today. What laboratories need now are two things above all: 1️⃣ More transparency in the journey of laboratory samples in order to identify errors at an early stage 🔎 2️⃣ A reduction in the workload of employees 🙇 In our expert interview, Dr. Oliver Gutmann, Business Product Manager at Roche Diagnostics, gives an insight into Roche Diagnostics’ navify® Sample Tracking solution to face exactly these problems – and tells us, why AI Robotics plays a major role in it. Read the full interview here ➡️ https://lnkd.in/efq_i9Uc #labautomation #laboratory #laborshortage #AI #automation #robotics

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Introducing... The KAPA Total Prep FFPE workflow from Roche. This novel NGS workflow simultaneously generates DNA and RNA libraries from a single input sample, without sacrificing performance. Now, you can: -Save time—with one workflow for RNA, DNA, and target enrichment -Save resources—including labor, reagents, and consumables Learn how: #NGS #NextGenSequencing #Genomics #DNA #RNA #LifeScience

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🔬 Missed yesterday's webinar on "What Makes Modern Lab Software for Pathology & Cytology?" Do not miss out on this second opportunity. But before you dive in, here is a sneak peek into what awaits: The key speakers, Philipp Alexander Maier and Dominik Gerber, discussed the benefits of seamlessly integrating every facet of your pathology lab – from material handling to report generation and reimbursement management into one platform. Topics Covered: ✔️ How to cover all the lab work activities from materials to reports in the most efficient way? ✔️How the continuously upgraded features such as Speech Recognition add value? ✔️ How to reduce errors, save time, and enhance the comfort of your daily activities. Don't miss out on the second chance and mark your calendars: 📅 May 22 (Wednesday): 0800-0820 CEST 🌐 https://lnkd.in/dani5s_q OR 📅 May 23 (Thursday): 1630-1650 CEST 🌐 https://lnkd.in/dx2b7Fah Register now and secure your seat. #Digitization #LabSoftware #SeamlessIntegration #WorkflowManagement

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Instapreserve has started making in roads in pathology as green alternative for fixative in pathology, ambient temperature biobanking and other applications #pathology #fixative #formaldehyde #biobanking

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Next battle of molecular technologies in wet laboratory practice will be in August, 2024. Let’s meet in Tomsk. Registration is open until June 28, 2024 at https://lnkd.in/eVkkN3RF There is real possibility to see different technologies, but you can try only one. It will be at the basis of one of the strongest scientific school. Newest technique at the market will be tried by the experts in single-cell analysis, flow cytometry and digital PCR. We are looking forward to results and opinions )) You could visit a lots of exhibitions but it’s real possibility to see real results in real lab. Here is the list of brands announced, subject to change…

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Standard in vitro genotoxicity tests like micronucleus assay can present limitations. In our case study, ToxTracker assay not only performed better than micronucleus assay in identifying genotoxicants, but also provided mode-of-action insights. Curious about this case study? Click on the link below. https://lnkd.in/dFfMB_Nx #toxtracker #genetic #toxicology #nams

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📺 You missed the #BIOPOLYMERCongress2024 but are keenly interested in the lectures? Then check out our #YouTube channel now. Here you will find all the presentations from 2024 as recordings: https://lnkd.in/e3ngPpz2 #biopolymer #biopolymercongress #thinkgreen 💚

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Join us at Swiss Biotech Day in Basel! Johannes Holzmeister & Robin Schonenberger are looking forward to discussing our unique approaches in drug delivery and development. #directoorgandelivery #genetherapy #advancedmedicines #humandiseasemodelling #biotechnology #SwissBioTechDay

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Take a look at fascinating 3D microscopy images and learn more about the various techniques for creating spheroids and organoids in the following ibidi GmbH blog article ➡️ https://abrir.link/ttQfO #lifesciences #enzifarma

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Missed the webinar with Lab Manager and Tomás de Garay, PhD? You can still view it on demand to hear about the capabilities of #massphotometry for the biophysical characterization of samples. Also, learn about MassFluidix HC, a novel add-on for mass photometry that expands the concentration range up to tens of micromolar for mass photometry samples. View the webinar here ➡ https://lnkd.in/dtjE-Me6

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🌟MCE WEBINAR TOMRROW🌟 Join us and talk with Dr. Johannes U. Mayer about Immunology tomrrow! 🗓 June 18, 2024 🕙 10:00 CEST/ 13:30 IST/ 17:00 JST&KST Tissue-Specific Differences in The Induction of Type 2 Immunity are Controlled by Specialized Dendritic Cell Subsets In this Webinar, You Will Learn: How type 2 immune responses are controlled in barrier tissues Novel tools to investigate the initiation of type 2 immunity Role of tissue-specific dendritic cells in the induction of type 2 immunity Implications of tissue-specific control of type 2 immunity Click the link below to register this webinar: https://lnkd.in/gGEfWPFt

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Nice analysis, Raul PARDO! Do you think there is any strategic / economic reason behind the choice of potent toxins for ADC development?. According to the Nov´22 Cancer Cell piece by Raffaele Colombo & Jamie Rich, the MTD of the ADC is correlated and limited by the MTD of the free toxin. This means the most potent toxins require less amount of mAb to be dosed at therapeutic levels. Moving to less toxic payloads (like the clinically proved topoI inhibitors, and the many submicromolar cytotoxics potentially useful) means higher MTD for those ADC, and higher manufacturing costs.... pehaps this was (or stil is) a factor driving payload choice. What do you think? Shall the manufacturing cost drop down significantly to open up the ADC field to new payloads?

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Download our whitepaper today to dive into the fascinating details of a study conducted at iFyber. You'll learn about their research on the inactivation of biofilms in an ex vivo porcine dermal model using the NovaSterilis scCO2 sterilization process. 🔍https://bit.ly/3P6eSgm

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Our colleague, Christian Reinhard, is attending this year's #Digestive #Disease #Week® (#DDW2024) together with our US sister company BUHLMANN Diagnostics Corp. He is presenting the latest research from BÜHLMANN Laboratories AG at this important event for  #gastroenterology experts. Join us for insightful discussions! #DDW #DDW2023 #DigestiveDiseaseWeek #gastroenterology #medicalconference #healthcare #medicine #research #immunology

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