The document summarizes updated guidelines from the World Society of Emergency Surgery (WSES) for the diagnosis and treatment of acute appendicitis. It provides background on acute appendicitis and discusses ongoing controversies in diagnosis and management. An updated consensus conference was held in 2019 to revise the original 2015 WSES Jerusalem guidelines. The updated 2020 guidelines aim to provide evidence-based statements and recommendations on topics including diagnosis, non-operative management, timing of surgery, surgical treatment, grading of appendicitis severity, and antibiotic therapy.
The document summarizes updated guidelines from the World Society of Emergency Surgery (WSES) on the diagnosis and treatment of acute appendicitis. It reviews the literature from April 2015 to June 2019 on key topics including diagnosis, non-operative management, timing of appendectomy, surgical treatment, grading of appendicitis severity, management of perforated appendicitis, and antibiotic use. 48 statements and 51 recommendations were developed based on 157 reviewed articles, following the GRADE methodology for evaluating evidence quality and strength of recommendations. The guidelines aim to provide evidence-based guidance on diagnosis and all aspects of acute appendicitis management.
The document provides an overview of eHealth and telemedicine in wound care. It defines key terms like eHealth, mHealth, telehealth, and telemedicine. The document also reviews literature on the use of eHealth in wound care and evaluates solutions based on the MAST framework. While evidence is still limited, studies show benefits like improved access to care and increased job satisfaction for clinicians. The document provides guidance for clinicians considering implementing eHealth applications and recommends evaluating outcomes to ensure efficient use.
Сравнение режимов лечения ВИЧ в разрезе различных клинических сценариев.ART...
This downloadable slideset summarizes optimal evidence-based antiretroviral therapy management strategies for a series of challenging clinical cases and is based on a satellite symposium presented at HIV Glasgow 2016.
Format: Microsoft PowerPoint (.ppt)
File size: 1.32 MB
Date posted: 11/11/2016
European guidance on estimating population doses from medical xray
This document provides guidance on estimating population doses from medical x-ray procedures in Europe. It discusses estimating the frequency of x-ray exams, assessing patient doses, and presenting results. The key purposes are to observe trends in collective dose over time, determine contributions by exam type, and allow international comparisons. Proper population dose estimates require accounting for the age and sex distributions of patients, as medical exposures are not uniform across populations. Regular assessments inform authorities on high exposure groups to focus radiation protection efforts.
Infections among people who inject drugs -- problem solved?
This document summarizes a presentation given by Anastasia Pharris of the European Centre for Disease Prevention and Control on infections among people who inject drugs. It finds that over 30,000 new HIV diagnoses in Europe in 2016 were due to injecting drug use, with most cases concentrated in Eastern Europe. While harm reduction efforts have made progress in some countries, people who inject drugs still face high burdens of HIV, hepatitis C, and other infections. The presentation calls for improved testing, treatment, and prevention programs targeting this group.
This document provides an updated 2020 Core Curriculum for Percutaneous Cardiovascular Interventions in Europe. It aims to define the level of experience and knowledge required of interventional cardiologists. The curriculum promotes standardized education and training programs across countries. It recommends at least two years of postgraduate training in addition to four years of cardiology training to achieve competence. The curriculum covers general training aspects and specific components in 54 chapters, defining objectives, required knowledge, skills, behaviors, and attitudes for each.
This document discusses bladder cancer in Europe. It notes that bladder cancer is the fifth most common cancer in Europe, yet it receives relatively little funding and resources compared to its disease burden. This lack of investment has resulted in few treatment options, delayed diagnosis, and low survival rates. Currently, up to half of all people diagnosed with bladder cancer in Europe will die within five years. The document identifies smoking and occupational exposure to carcinogenic chemicals as the main preventable risk factors for bladder cancer. It calls for more European action to reduce these risk factors and improve early diagnosis, treatment, and outcomes for bladder cancer patients.
Tele-Cardiology Services in the UK - Telehealth Magazine (April 2008)
The document summarizes a pilot study conducted in the UK that tested a tele-cardiology service using wireless electrocardiogram (ECG) devices. The devices transmitted ECG readings from primary care clinics to a monitoring center where clinicians interpreted the results and provided advice. The pilot found the tele-cardiology service improved patient care by expediting diagnosis, eliminating some emergency visits, and increasing information quality for hospital visits. It also identified potential for huge cost savings compared to standard care.
HAI-Net ICU results and perspectives. Carl Suetens (ECDC)
Presentation from the 3rd Joint Meeting of the Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI) Networks, organised by the European Centre of Disease Prevention and Control - Stockholm, 11-13 February 2015
From innovation to implementation – eHealth in the WHO European Region (2016)
This document provides an overview of eHealth in the WHO European Region. It begins with an introduction that discusses universal health coverage and the European Health Information Initiative. It then covers several topics related to eHealth including electronic health records, telehealth, mHealth, eLearning in health, social media in health, health analytics and big data in health, and legal frameworks for eHealth. Each section provides data from the 2015 WHO global survey on eHealth in the European Region. The document concludes by recognizing the progress made by countries in adopting eHealth and highlighting emerging areas like big data and social media that hold potential to further improve health care and policy.
The document discusses EU initiatives on organ donation and transplantation, including a directive and action plan. The action plan aims to increase organ availability, make transplantation systems more efficient and accessible, and improve quality and safety. It outlines 10 priority actions to achieve these goals, such as promoting quality improvement programs in hospitals and developing common accreditation systems. The directive and action plan seek to establish common standards and policies across EU countries to strengthen cooperation on organ donation and transplantation.
Management of patients_with_venous_leg_ulcers_final_2016
This document provides clinical practice statements for the management of patients with venous leg ulcers. It aims to identify barriers and facilitators to implementing best practices based on guidelines. The document was created by an international expert working group to account for differences in healthcare systems worldwide and address gaps in current guidelines. Clinical practice statements cover the differential diagnosis and assessment of leg ulcers, treatment delivery including dressings and invasive options, referral structures, secondary prevention after healing, and outcome monitoring. The goal is to improve leg ulcer management and enhance the patient experience.
The document discusses the potential benefits of eHealth (ICT for health) in Europe. It notes that while the health sector employs over 9% of the EU workforce, ICT penetration in health is relatively low compared to other sectors. eHealth can improve efficiency and productivity, support chronic disease management and preventive care, and empower patients. The EU is a world leader in deploying ICT in primary care settings. Further development of eHealth requires addressing issues like interoperability, business models, and research into areas like personalized medicine.
1st Hepatitis E virus expert meeting at ECDC, Introduction
The expert group meeting discussed hepatitis E virus (HEV) epidemiology, surveillance, and risks in the EU/EEA. HEV is an under-surveilled cause of hepatitis worldwide with different genotypes infecting people. While most EU cases were previously travel-related, HEV genotype 3 is now endemic in Europe with an animal reservoir. Surveillance varies between countries with no EU-wide system. The group aims to inventory HEV in Europe by surveying countries on surveillance methods and collecting case numbers to describe epidemiology and populations at risk. This will identify needs for EU guidance on diagnosis, risk assessment, and prevention strategies to respond to HEV health threats.
DVTech - a novel wearable medical device to detect Deep Vein ThrombosisMalavikaSankararaman
Development of DVTech – a novel wearable medical device for the detection of Deep Vein Thrombosis caused due to orthopaedic implants, using Pugh’s total design model
This document provides an overview of complementary and alternative medicine (CAM) in Europe. It discusses CAM's holistic approach and roots in traditional healing practices. The document notes that CAM is now used by about half of EU citizens and is practiced by around 145,000 dual-trained CAM/conventional medicine doctors and 160,000 CAM practitioners across Europe. However, CAM provision varies greatly by country. The document calls for steps to better integrate CAM into European healthcare systems in line with WHO recommendations, ensure adequate regulation and training of CAM providers, improve access to CAM products and therapies, and increase public investment in CAM research.
'Investigar, educar, dialogar. Las lecciones que aprendimos de José Mariano Gago (1948-2015)'. Con este título celebramos los días 1 y 2 de junio de 2016 en la Fundación Ramón Areces un simposio para homenajear la trayectoria de quien fue ministro de Ciencia y Tecnología (1995-2002) y ministro de Ciencia, Tecnología y Educación Superior (2005-2011) de Portugal. Gago desempeñó una labor crucial en el diseño de los planes de desarrollo de la ciencia, la tecnología y la innovación, no solo en su país sino en toda Europa.
The document summarizes updated guidelines from the World Society of Emergency Surgery (WSES) for the diagnosis and treatment of acute appendicitis. It provides background on acute appendicitis and discusses ongoing controversies in diagnosis and management. An updated consensus conference was held in 2019 to revise the original 2015 WSES Jerusalem guidelines. The updated 2020 guidelines aim to provide evidence-based statements and recommendations on topics including diagnosis, non-operative management, timing of surgery, surgical treatment, grading of appendicitis severity, and antibiotic therapy.
The document summarizes updated guidelines from the World Society of Emergency Surgery (WSES) on the diagnosis and treatment of acute appendicitis. It reviews the literature from April 2015 to June 2019 on key topics including diagnosis, non-operative management, timing of appendectomy, surgical treatment, grading of appendicitis severity, management of perforated appendicitis, and antibiotic use. 48 statements and 51 recommendations were developed based on 157 reviewed articles, following the GRADE methodology for evaluating evidence quality and strength of recommendations. The guidelines aim to provide evidence-based guidance on diagnosis and all aspects of acute appendicitis management.
The document provides an overview of eHealth and telemedicine in wound care. It defines key terms like eHealth, mHealth, telehealth, and telemedicine. The document also reviews literature on the use of eHealth in wound care and evaluates solutions based on the MAST framework. While evidence is still limited, studies show benefits like improved access to care and increased job satisfaction for clinicians. The document provides guidance for clinicians considering implementing eHealth applications and recommends evaluating outcomes to ensure efficient use.
Сравнение режимов лечения ВИЧ в разрезе различных клинических сценариев.ART...hivlifeinfo
This downloadable slideset summarizes optimal evidence-based antiretroviral therapy management strategies for a series of challenging clinical cases and is based on a satellite symposium presented at HIV Glasgow 2016.
Format: Microsoft PowerPoint (.ppt)
File size: 1.32 MB
Date posted: 11/11/2016
European guidance on estimating population doses from medical xrayAna Pires
This document provides guidance on estimating population doses from medical x-ray procedures in Europe. It discusses estimating the frequency of x-ray exams, assessing patient doses, and presenting results. The key purposes are to observe trends in collective dose over time, determine contributions by exam type, and allow international comparisons. Proper population dose estimates require accounting for the age and sex distributions of patients, as medical exposures are not uniform across populations. Regular assessments inform authorities on high exposure groups to focus radiation protection efforts.
This document summarizes a presentation given by Anastasia Pharris of the European Centre for Disease Prevention and Control on infections among people who inject drugs. It finds that over 30,000 new HIV diagnoses in Europe in 2016 were due to injecting drug use, with most cases concentrated in Eastern Europe. While harm reduction efforts have made progress in some countries, people who inject drugs still face high burdens of HIV, hepatitis C, and other infections. The presentation calls for improved testing, treatment, and prevention programs targeting this group.
This document provides an updated 2020 Core Curriculum for Percutaneous Cardiovascular Interventions in Europe. It aims to define the level of experience and knowledge required of interventional cardiologists. The curriculum promotes standardized education and training programs across countries. It recommends at least two years of postgraduate training in addition to four years of cardiology training to achieve competence. The curriculum covers general training aspects and specific components in 54 chapters, defining objectives, required knowledge, skills, behaviors, and attitudes for each.
This document discusses bladder cancer in Europe. It notes that bladder cancer is the fifth most common cancer in Europe, yet it receives relatively little funding and resources compared to its disease burden. This lack of investment has resulted in few treatment options, delayed diagnosis, and low survival rates. Currently, up to half of all people diagnosed with bladder cancer in Europe will die within five years. The document identifies smoking and occupational exposure to carcinogenic chemicals as the main preventable risk factors for bladder cancer. It calls for more European action to reduce these risk factors and improve early diagnosis, treatment, and outcomes for bladder cancer patients.
Tele-Cardiology Services in the UK - Telehealth Magazine (April 2008)Ofer Atzmon
The document summarizes a pilot study conducted in the UK that tested a tele-cardiology service using wireless electrocardiogram (ECG) devices. The devices transmitted ECG readings from primary care clinics to a monitoring center where clinicians interpreted the results and provided advice. The pilot found the tele-cardiology service improved patient care by expediting diagnosis, eliminating some emergency visits, and increasing information quality for hospital visits. It also identified potential for huge cost savings compared to standard care.
Presentation from the 3rd Joint Meeting of the Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI) Networks, organised by the European Centre of Disease Prevention and Control - Stockholm, 11-13 February 2015
From innovation to implementation – eHealth in the WHO European Region (2016)Market iT
This document provides an overview of eHealth in the WHO European Region. It begins with an introduction that discusses universal health coverage and the European Health Information Initiative. It then covers several topics related to eHealth including electronic health records, telehealth, mHealth, eLearning in health, social media in health, health analytics and big data in health, and legal frameworks for eHealth. Each section provides data from the 2015 WHO global survey on eHealth in the European Region. The document concludes by recognizing the progress made by countries in adopting eHealth and highlighting emerging areas like big data and social media that hold potential to further improve health care and policy.
The document discusses EU initiatives on organ donation and transplantation, including a directive and action plan. The action plan aims to increase organ availability, make transplantation systems more efficient and accessible, and improve quality and safety. It outlines 10 priority actions to achieve these goals, such as promoting quality improvement programs in hospitals and developing common accreditation systems. The directive and action plan seek to establish common standards and policies across EU countries to strengthen cooperation on organ donation and transplantation.
Management of patients_with_venous_leg_ulcers_final_2016GNEAUPP.
This document provides clinical practice statements for the management of patients with venous leg ulcers. It aims to identify barriers and facilitators to implementing best practices based on guidelines. The document was created by an international expert working group to account for differences in healthcare systems worldwide and address gaps in current guidelines. Clinical practice statements cover the differential diagnosis and assessment of leg ulcers, treatment delivery including dressings and invasive options, referral structures, secondary prevention after healing, and outcome monitoring. The goal is to improve leg ulcer management and enhance the patient experience.
The document discusses the potential benefits of eHealth (ICT for health) in Europe. It notes that while the health sector employs over 9% of the EU workforce, ICT penetration in health is relatively low compared to other sectors. eHealth can improve efficiency and productivity, support chronic disease management and preventive care, and empower patients. The EU is a world leader in deploying ICT in primary care settings. Further development of eHealth requires addressing issues like interoperability, business models, and research into areas like personalized medicine.
1st Hepatitis E virus expert meeting at ECDC, IntroductionCornelia Adlhoch
The expert group meeting discussed hepatitis E virus (HEV) epidemiology, surveillance, and risks in the EU/EEA. HEV is an under-surveilled cause of hepatitis worldwide with different genotypes infecting people. While most EU cases were previously travel-related, HEV genotype 3 is now endemic in Europe with an animal reservoir. Surveillance varies between countries with no EU-wide system. The group aims to inventory HEV in Europe by surveying countries on surveillance methods and collecting case numbers to describe epidemiology and populations at risk. This will identify needs for EU guidance on diagnosis, risk assessment, and prevention strategies to respond to HEV health threats.
Similar to ThrombUS+ Project Overview - Horizon Europe Networking Event June 2024 (20)
Dalghren, Thorne and Stebbins System of Classification of AngiospermsGurjant Singh
The Dahlgren, Thorne, and Stebbins system of classification is a modern method for categorizing angiosperms (flowering plants) based on phylogenetic relationships. Developed by botanists Rolf Dahlgren, Robert Thorne, and G. Ledyard Stebbins, this system emphasizes evolutionary relationships and incorporates extensive morphological and molecular data. It aims to provide a more accurate reflection of the genetic and evolutionary connections among angiosperm families and orders, facilitating a better understanding of plant diversity and evolution. This classification system is a valuable tool for botanists, researchers, and horticulturists in studying and organizing the vast diversity of flowering plants.
Possible Anthropogenic Contributions to the LAMP-observed Surficial Icy Regol...Sérgio Sacani
This work assesses the potential of midsized and large human landing systems to deliver water from their exhaust
plumes to cold traps within lunar polar craters. It has been estimated that a total of between 2 and 60 T of surficial
water was sensed by the Lunar Reconnaissance Orbiter Lyman Alpha Mapping Project on the floors of the larger
permanently shadowed south polar craters. This intrinsic surficial water sensed in the far-ultraviolet is thought to be
in the form of a 0.3%–2% icy regolith in the top few hundred nanometers of the surface. We find that the six past
Apollo Lunar Module midlatitude landings could contribute no more than 0.36 T of water mass to this existing,
intrinsic surficial water in permanently shadowed regions (PSRs). However, we find that the Starship landing
plume has the potential, in some cases, to deliver over 10 T of water to the PSRs, which is a substantial fraction
(possibly >20%) of the existing intrinsic surficial water mass. This anthropogenic contribution could possibly
overlay and mix with the naturally occurring icy regolith at the uppermost surface. A possible consequence is that
the origin of the intrinsic surficial icy regolith, which is still undetermined, could be lost as it mixes with the
extrinsic anthropogenic contribution. We suggest that existing and future orbital and landed assets be used to
examine the effect of polar landers on the cold traps within PSRs
Keys of Identification for Indian Wood: A Seminar ReportGurjant Singh
Identifying Indian wood involves recognizing key characteristics such as grain patterns, color, texture, hardness, and specific anatomical features. These identification keys include observing the wood's pores, growth rings, and resin canals, as well as its scent and weight. Understanding these features is essential for accurate wood identification, which is crucial for various applications in carpentry, furniture making, and conservation.
Additionally, the application of Convolutional Neural Networks (CNN) in wood identification has revolutionized this field. CNNs can analyze images of wood samples to identify species with high accuracy by learning and recognizing intricate patterns and features. This technological advancement not only enhances the precision of wood identification but also accelerates the process, making it more efficient for industry professionals and researchers alike.
Hydrogen sulfide and metal-enriched atmosphere for a Jupiter-mass exoplanetSérgio Sacani
We observed two transits of HD 189733b in JWST program 1633 using JWST
NIRCam grism F444W and F322W2 filters on August 25 and 29th 2022. The first
visit with F444W used SUBGRISM64 subarray lasting 7877 integrations with 4
BRIGHT1 groups per integration. Each effective integration is 2.4s for a total effective exposure time of 18780.9s and a total exposure duration of 21504.2s (∼6 hrs)
including overhead. The second visit with F322W2 used SUBGRISM64 subarray
lasting 10437 integrations with 3 BRIGHT1 groups per integration. Each effective
integration is 1.7s for a total effective exposure time of 17774.7s and a total exposure
duration of 21383.1s (∼6 hrs) including overhead. The transit duration of HD189733
b is ∼1.8 hrs and both observations had additional pre-ingress baseline relative to
post-egress baseline in anticipating the potential ramp systematics at the beginning
of the exposure from NIRCam infrared detectors.
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The cryptoterrestrial hypothesis: A case for scientific openness to a conceal...Sérgio Sacani
Recent years have seen increasing public attention and indeed concern regarding Unidentified
Anomalous Phenomena (UAP). Hypotheses for such phenomena tend to fall into two classes: a
conventional terrestrial explanation (e.g., human-made technology), or an extraterrestrial explanation
(i.e., advanced civilizations from elsewhere in the cosmos). However, there is also a third minority
class of hypothesis: an unconventional terrestrial explanation, outside the prevailing consensus view of
the universe. This is the ultraterrestrial hypothesis, which includes as a subset the “cryptoterrestrial”
hypothesis, namely the notion that UAP may reflect activities of intelligent beings concealed in stealth
here on Earth (e.g., underground), and/or its near environs (e.g., the moon), and/or even “walking
among us” (e.g., passing as humans). Although this idea is likely to be regarded sceptically by most
scientists, such is the nature of some UAP that we argue this possibility should not be summarily
dismissed, and instead deserves genuine consideration in a spirit of epistemic humility and openness.
Collaborative Team Recommendation for Skilled Users: Objectives, Techniques, ...Hossein Fani
Collaborative team recommendation involves selecting users with certain skills to form a team who will, more likely than not, accomplish a complex task successfully. To automate the traditionally tedious and error-prone manual process of team formation, researchers from several scientific spheres have proposed methods to tackle the problem. In this tutorial, while providing a taxonomy of team recommendation works based on their algorithmic approaches to model skilled users in collaborative teams, we perform a comprehensive and hands-on study of the graph-based approaches that comprise the mainstream in this field, then cover the neural team recommenders as the cutting-edge class of approaches. Further, we provide unifying definitions, formulations, and evaluation schema. Last, we introduce details of training strategies, benchmarking datasets, and open-source tools, along with directions for future works.
Properties of virus(Ultrastructure and types of virus)
ThrombUS+ Project Overview - Horizon Europe Networking Event June 2024
1. Project Overview
E. Kaldoudi |ATHENA RC | Greece
Horizon Europe Health Cluster Networking Meeting
26 June 2024
Co-funded by the
European Union
2. Co-funded by the European Union
Horizon Europe Health Cluster Networking Meeting | 26 June 2024
Wearable Continuous Point-of-Care Monitoring,
Risk Estimation and Prevention for Deep Vein Thrombosis
Project type: IA (Innovation Action)
Project Budget: 9,565,763.75 €
EU funding: 8,141,251.25 €
Duration: 42 months
Start: 1 January 2024
End: 30 June 2027
Invited: 04 August 2023
Signed: 08 December 2023
Call Identifier: HORIZON-HLTH-2023-TOOL-05-05
Call title: Harnessing the potential of real-time data
analysis and secure Point-of-Care computing for the
benefit of person-centred health and care delivery
Program: Horizon Europe, 4. Health, 2023-2024
Destination: 5. Unlocking the full potential of new tools,
technologies and digital solutions for a healthy society
Proposal submitted: 13 April 2023
2
3. Co-funded by the European Union
Greece
Lithuania
Germany
Italy
France
Finland
Spain
USA
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 3
5. Co-funded by the European Union
Deep Vein Thrombosis (DVT) is the
clotting of blood in a deep vein of
the pelvis or an extremity
(usually calf or thigh)
https://www.usaveinclinics.com/vein-disease/deep-vein-thrombosis-dvt/ June 2024
https://www.cdc.gov/blood-clots/data-research/facts-
stats/index.html#:~:text=The%20precise%20number%20of%20people,die%20of%20VTE%20each%20year. June 2024
a clot is mainly composed of fibrin and red
blood cells and may contain platelets,
leukocytes and other compounds
a clot usually forms around the valves
in the deep veins of the leg
a clot forms in a matter of seconds or
minutes depending on the individual
when present, the clot disturbs the flow of
blood and results in pain and swelling
the clot might be pushed via the heart to
the lungs where it can block an artery,
what is know as pulmonary embolism,
an acute, life-threatening event
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 5
6. Co-funded by the European Union
Deep Vein Thrombosis (DVT) is a major preventable cause
of morbidity and mortality worldwide
▪ 3rd most frequent vascular diagnosis after heart attack and stroke,
▪ affects more than 1,000,000 Americans per year
affects more than 700,000 Europeans per year
▪ 1/2 of people with DVT
experience a sudden pulmonary embolism
▪ about 25% of those who have a pulmonary embolism die from it
▪ 1/3 to 1/2 of people who have a DVT episode will have long-term
complications caused by the damage the clot does to the valves in the vein
▪ annual health expenditure related to DVT is €8.5 billion in EU
Olaf M et al. Deep Venous
Thrombosis. Emerg Med Clin North
Am. 2017 doi:
10.1016/j.emc.2017.06.003
Cohen AT et al. Thromb Haemost.
2007 Oct;98(4):756-64
Barco S et al.Thromb Haemost. 2016
Apr;115(4):800-8. doi: 10.1160/TH15-
08-0670
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 6
7. Co-funded by the European Union
Horizon Europe Health Cluster Networking Meeting | 26 June 2024
clinical conditions most closely
associated with DVT
surgery or trauma
malignancy
prolonged immobility
pregnancy
congestive heart failure
varicose veins
obesity
advancing age
history of DVT
of all DVT episodes
50% no obvious cause
20% cancer related
20% after surgery
7
8. Co-funded by the European Union
graduated
compression stockings
Horizon Europe Health Cluster Networking Meeting | 26 June 2024
Sachdeva A, Dalton M, Lees T. Graduated compression stockings for prevention of deep vein
thrombosis. Cochrane Database Syst Rev. 2018 Nov 3;11(11):CD001484.
https://doi.org/10.1002/14651858.CD001484.pub4
Yang SD, Ning SH, Zhang LH, Zhang YZ, Ding WY, Yang DL. The effect of lower limb rehabilitation
gymnastics on postoperative rehabilitation in elderly patients with femoral shaft fracture: A
retrospective case-control study. Medicine (Baltimore). 2016 Aug;95(33):e4548.
https://doi.org/10.1097/MD.0000000000004548 .
rehabilitation gymnastics
prevention of deep vein thrombosis employs
anti-thrombotic medication and …
8
9. Co-funded by the European Union
currently, ultrasonography is the
method of choice for DVT diagnosis
▪ direct visualization of the thrombus
▪ Doppler to assess venous flow
▪ compression
ultrasound
while compressing with the US probe
till the artery starts to compress,
when normal,
the vein fully collapses
when DVT is present,
vein does NOT collapse
artery
vein
compression US
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 9
10. Co-funded by the European Union
other modalities for DVT diagnosis
Light Reflection Rheography
measures blood volume changes in
peripheral veins via reflection of light
Electrical Impedance Plethysmography
measures blood volume changes in
peripheral veins via electrical impedance
changes
Credits: S. Balling, medis.
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 10
11. Co-funded by the European Union
prompt diagnosis of DVT is crucial!
patients are referred for an ultrasound
when they present DVT-related clinical
symptoms
however,…
up to 2/3 of DVT episodes are clinically
silent and patients are symptom free
pulmonary embolism events are
acute, and about 25% of these result in
death immediately or in a few hours,
before a treatment can be applied
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 11
12. Co-funded by the European Union
wearable ultrasound for DVT continuous monitoring
coupled with
impedance plethysmography
light reflection rheography
activity sensors (patient and doctor empowerment)
other info (assessment of DVT risk)
with AI support for autonomous monitoring,
DVT risk assessment and
DVT early detection image generated by MS Designer https://designer.microsoft.com/image-creator
prompt: “a patient lying in a bed with subtle multiple sensors on the leg embedded
in a legging with a screen in the background displaying leg movements”
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 12
13. Co-funded by the European Union
Horizon Europe Health Cluster Networking Meeting | 26 June 2024
B
A B
2 types of bulk technology US
transducers by VERMON
MEMS technology US
transducer by FRAUNHOFER
Beamforming by
TELEMED
smart textile
wearable by
ComfTech
electrical impedance
plethysmography
by TAU
light reflection
rheography
by MEDIS
activity sensor
network
by KTU
pressure
micropump
by KTU
AI based ultrasound
DVT detection by
EchoNous
AI based DVT
detection based on
EIP and LRR
by TAU and MEDIS
DVT risk detection, activity
based serious game and
extended reality by
ATHENA
central
intelligence
and app
by ATHENA
WP3
WP4
WP5
WP3
WP6
13
14. Co-funded by the European Union
Horizon Europe Health Cluster Networking Meeting | 26 June 2024
Clinical Studies
A Conventional ultrasound image set collection to create a training data set
Participants >3000
B1 Training data set collection using the prototype wearable ultrasound to fine tune the AI
model
Participants >500
B2 Physiological signals, lower limb activity and plethysmography measurements via the
ThrombUS+ prototype wearable sensor components from healthy volunteers
Participants >60
C1 Early feasibility study of the ThrombUS+ integrated prototype in patients in the
postoperative ward
Participants 25-50
C2 Prospective, double-blinded, pilot study evaluating artificial intelligence driven automatic
detection of deep vein thrombosis by the ThrombUS+ device compared to standard
ultrasound imaging in patients suspected for deep vein thrombosis
Participants: 50-100
14
15. Co-funded by the European Union
Horizon Europe Health Cluster Networking Meeting | 26 June 2024
Hospital Name Total TAU LSMU GNP CSS- IRCCS HSV
Country 5 countries Finland Lithuania Greece Italy France
Number of beds 5,703 1,000 2,232 745 750 976
Hospitalizations per
year
335,372 82,897 83,192 94,205 45,000 30,078
Out-patients per year 3,171,401 1,162,227 1,228,783 244,227 300,000 236,164
Patients scanned for
suspected DVT per
year
11,189 3,500 4,000 939 2,400 350
Positive scans for DVT
per year
2,255 700 800 188 500 67
Surgical operations per
year
136,252 40,896 66,254 10,669 8,000 10,433
Orthopaedics
operations per year
21,232 13,000 4,945 1,137 600 1,550
*based on data for year 2022
15
16. Co-funded by the European Union
patient centric design
• clinical survey amongst experts to
identify major patient categories in risk
of DVT and in need of continuousaaa
monitoring
• expert structured interviews to identify
patient practical needs, opportunities
and barriers for continuous monitoring
• patient focus groups (planned)
7 major reference use cases
Credits: Lucas J. Segal and Federico Puppo, PBY
ThrombUS+
Reference Use Cases
after surgery
perinatal care
cancer
obesity
prolonged immobility
history of thrombosis
genetic disorders
based on literature, of all DVT episodes
50% no obvious cause
20% cancer related
20% after surgery
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 16
17. Co-funded by the European Union
data driven approach
Table 1. Hospitals participating in the ThrombUS+ Clinical Study A.
Hospital TAU LSMU GNP CSS-IRCCS HSV Total
Country Finland Lithuania Greece Italy France 5 countries
Number of beds 1,000 2,232 745 750 976 5,703
Hospitalizations per year 82,897 83,192 94,205 45,000 30,078 335,372
Out-patients per year 1,162,227 1,228,783 244,227 300,000 236,164 3,171,401
Patients scanned for suspected
DVT per year
3,500 4,000 939 2,400 350 11,189
Table 1. Collective numerical data for the ThrombUS_A study.
Total number of patients referred for an ultrasound scan for suspected DVT per year 11,189
Positive DVT scans per year 2,547
Positive DVT scans as a percentage of referred and scanned patients per year 22%
Duration of the study (in months) 12
Estimated patients available for recruitment 11,000
Expected patients to recruit 3,000
Expected patients to recruit as a percentage for available for recruitment 27%
Expected positive scans in the recruited population (20%) 660
conventional ultrasound image set
collection to create a training data set
Participants >3000
the annonated data set will
be available to the public!
Drougka I, Clinical studies initiation package - Study A, Deliverable 7.1, ThrombUS+ Horizon Europe Innovation
Action, EC Grant Agreement No. 101137227, 31 May 2024, https://doi.org/10.5281/zenodo.11371924
Table 1. A summary of milestones regarding the ThrombUS+ Clinical Study A
Milestone Planned date
IRB/IEC approval June 2024
Start of data collection July 2024
Midterm recruitment report December 2024
End of data collection June 2025
Final report of study results July 2025
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 17
18. Co-funded by the European Union
compliance by design
research based on a regulatory
compliance monitoring plan
creation of regulatory templates
for the technical documentation
preparation of draft documents
from templates
distribution of draft documents
to project partners for feedback
review of feedback and
incorporation into draft documents
knowledge transfer on
specific regulatory topics Credits: Thorsten Prinz, VDE
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 18
19. Co-funded by the European Union
open science
Standards
• DICOM
Digital Imaging and Communication in Medicine
• GDF
Geographic Data Files
• ICD
International Classification of Diseases
• SNOMED-CT
Systemized Nomenclature of Medicine – Clinical Terms
https://thrombus.eu/
https://zenodo.org/communities/thrombus/
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 19
20. Co-funded by the European Union
work
package
breakdown
WP 1. Management
WP 2. Requirements and product co-design
WP 3. Ultrasound sensing
WP 4. Plethysmography, activity sensors and wearable
WP 5. Decision support and action intelligence
WP 6. Integration and validation
WP 7. Clinical studies
WP 8. Dissemination & Communication
WP 9. Exploitation, and Commercialization
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 20
21. WP10. Exploitation & Commercialization
Study A – Conventional
data collection
Τ7.2
Automated US DVT
detection
Τ5.1
Clinical studies
initiation
Τ7.1
ThrombUS+ specs
Τ6.1
Hardware
integration
Τ6.3
Software integration
intelligence and app
Τ6.4
Testing methodology
and plans
Τ6.2
Patient-centric cases and
requirements definition
Τ2.1
Regulatory framework,
security, safety and ethics
Τ2.2
WP1. Management
WP8. Dissemination & Communication
WP9. Exploitation & Commercialization
Testing, signal quality and
performance enhancements
Τ4.5
Manufacturing of
wearable prototypes
Τ4.6
Wearable development and
integration with sensors
Τ4.4
Testing, image quality and
performance enhancements
Τ3.5
Manufacturing of
US prototypes
Τ3.6
Transducer/cuff control and
image formation
Τ3.4
Studies B – Data collection
by prototype components
Τ7.3
Studies C – Clinical
trials
Τ7.4
Hardware and
software integration
& communications
Τ6.5
Posting of clinical
trial results
Τ7.5
Technical and functional
requirements
Τ2.4
Co-creation of wearable
strap and sock design
Τ2.3
Light reflection rheography
sensors development
Τ4.2
Lower limb activity sensor
network development
Τ4.3
Impedance sensors
development
Τ4.1
Precise tissue compression
actuator
Τ3.3
Ultrasound transducer array
Bulk technology
Τ3.1
Ultrasound transducer array
MEMS technology
Τ3.2
DVT risk estimation
Τ5.3
Automated
plethysmography
DVT detection
Τ5.2
Serious game for
DVT prevention
Τ5.5
Extended reality for
guidance
Τ5.4
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 21
22. Co-funded by the European Union
Horizon Europe Health Cluster Networking Meeting | 26 June 2024
# No Lead Type Dissem Month Date
1 D8.1 SciGen DEC PU 1 Jan 2024
2 D1.1 ATHENA DEC SEN 1 Jan 2024
3 D10.1 ATHENA ETHICS SEN 1 Jan 2024
4 D1.2 ATHENA R SEN 3 Mar 2024
5 D1.3 MEDEA R SEN 3 Mar 2024
6 D8.2 SciGen R PU 3 Mar 2024
7 D9.1 VDE R PU 3 Mar 2024
8 D1.4 ATHENA DMP PU 4 Apr 2024
9 D7.1 PHAZE R PU 5 May 2024
10 D2.1 PBY R PU 6 Jun 2024
11 D2.2 VDE R PU 8 Aug 2024
12 D2.3 KTU R PU 10 Oct 2024
13 D2.4 ComfTech R SEN 12 Dec 2024
14 D3.1 VERMON DEM SEN 12 Dec 2024
15 D3.2 FRAUNHOFER DEM SEN 12 Dec 2024
16 D3.3 KTU DEM SEN 12 Dec 2024
17 D4.1 TAU DEM SEN 12 Dec 2024
18 D4.2 MEDIS DEM SEN 12 Dec 2024
19 D4.3 KTU DEM SEN 12 Dec 2024
20 D7.2 PHAZE R PU 12 Dec 2024
21 D7.3 PHAZE R PU 13 Jan 2025
22 D6.1 KTU R PU 14 Feb 2025
23 D3.4 TELEMED DEM SEN 15 Mar 2025
24 D7.4 PHAZE R PU 15 Mar 2025
25 D4.4 ComfTech DEM SEN 16 Apr 2025
26 D6.2 KTU R PU 18 Jun 2025
27 D3.5 KTU R PU 19 Jul 2025
28 D4.5 KTU R PU 19 Jul 2025
# No Lead Type Dissem Month Date
29 D7.5 PHAZE R PU 20 Aug 2025
30 D3.6 TELEMED DEM SEN 21 Sep 2025
31 D4.6 ComfTech DEM SEN 21 Sep 2025
32 D1.5 ATHENA DMP PU 24 Dec 2025
33 D7.6 PHAZE R PU 24 Dec 2024
34 D6.3 KTU DEM SEN 26 Feb 2026
35 D8.3 ATHENA DATA PU 26 Feb 2026
36 D5.1 EchoNous DEM SEN 28 Apr 2026
37 D5.2 TAU DEM SEN 28 Apr 2026
38 D5.3 ATHENA DEM SEN 28 Apr 2026
39 D5.4 ATHENA DEM SEN 28 Apr 2026
40 D5.5 ATHENA DEM SEN 28 Apr 2026
41 D6.4 ATHENA DEM SEN 28 Apr 2026
42 D7.7 PHAZE R PU 29 May 2026
43 D6.5 KTU DEM SEN 32 Aug 2026
44 D7.8 PHAZE R PU 36 Dec 2026
45 D1.6 ATHENA R SEN 42 Jun 2027
46 D1.7 MEDEA R SEN 42 Jun 2027
47 D7.9 PHAZE R PU 42 Jun 2027
48 D8.4 SciGen R PU 42 Jun 2027
49 D8.5 SciGen R PU 42 Jun 2027
50 D9.2 VDE R PU 42 Jun 2027
51 D9.3 PBY R PU 42 Jun 2027
52 D9.4 MEDEA R SEN 42 Jun 2027
53 D10.5 ATHENA ETHICS SEN 42 Jun 2027
54 D10.2 ATHENA ETHICS SEN 12 Dec 2024
55 D10.3 ATHENA ETHICS SEN 24 Dec 2025
56 D10.4 ATHENA ETHICS SEN 36 Dec 2026
52 +4
deliverables
22
23. Co-funded by the European Union
project progress
• 1st milestone
reached
• 9 deliverables
submitted on time
Horizon Europe Health Cluster Networking Meeting | 26 June 2024 23
24. Project Meeting 02 |Kaunas, Lithuania | 14-15 May 2024
Seal of Excellence by France
the project scored the maximum of 4/4
in all 10 evaluation criteria
25. Co-funded by the European Union
submitted public deliverables or publishable summaries
can be viewed in the project website and
in the project’s community in Zenodo
Horizon Europe Health Cluster Networking Meeting | 26 June 2024
https://thrombus.eu/
25
27. Coordinator: Prof. Eleni Kaldoudi, Coordinator
kaldoudi@athenarc.gr
Project Manager: Dr. Stelios Didaskalou
stelios.didaskalou@athenarc.gr
https://www.linkedin.com/co
mpany/thrombus-eu-project/
https://thrombus.eu/
thrombus-project@athenarc.eu
Co-funded by the
European Union