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The MACRAMÉ project has received funding from the European Union’s Horizon Europe
Research and Innovation programme under grant agreement No. 101092686.
Associated Partners (i.e. (a) Swiss Partners and (b) UK Partners) have received national funding from
(a) the Swiss State Secretariat for Education, Research and Innovation (SERI), and (b) Innovate UK.
Patchwork Project Family &
Sibling Projects
– MACRAMÉ-ChIPs
24th Meeting of the OECD Working Party on Manufactured Nanomaterials (WPMN)
26th – 28th June 2024, Paris
HORIZON-CL4-2023-
RESILIENCE-01-21:
Innovative methods for safety
and sustainability assessments
of chemicals and materials
(RIA)
HORIZON-CL4-2023-
RESILIENCE-01-22: Integrated
approach for impact
assessment of safe and
sustainable chemicals and
materials (RIA)
HORIZON-CL4-2023-
RESILIENCE-01-23:
Computational models for the
development of safe and
sustainable by design
chemicals and materials (RIA)
>>> decreasing Experimental (lab) work >>>
>>> increasing in silico work >>>
Sharing of Case-Studies of specific
Chemicals & Materials
Integration of shared computational Methods
total budget: € 23.2 Mio. (ca. ¾ from EU, ¼ non-EU)  37 individual Research Institutions;  Jan. 2024 – Dec. 2027
24th OECD WPMN
26th – 28th June 2024, Paris
The CHIASMA Project has received funding from:
The European Union’s Horizon Europe
Research and Innovation programme
under grant agreement No. 101137613.
ACCESSIBLE INNOVATIVE METHODS
FOR THE SAFETY & SUSTAINABILITY
ASSESSMENT OF CHEMICALS & MATERIALS
24th Working Party on Manufacture Nanomaterials (WPMN)
26th – 28th June 2024
The CHIASMA R&I Approach
24th OECD WPMN
26th – 28th June 2024, Paris
4
Combining an iterative
approach of:
(1) chemocentric,
(2) biocentric, and
(3) new experimental
models
into a conceptual
framework for data-
integration and -
processing.
Illustration of the CHIASMA R&I approach to testing and assessment of materials.

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epaepa researchh2020
The INSIGHT Project has received funding from:
The European Union’s Horizon Europe Research
and Innovation programme under grant
agreement No. 101137742.
Funding Agency
Australia
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USA
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Assessment of High Impact Chemicals and Materials
24th OECDWorking Party on Manufactured Nanomaterials (WPMN)
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R&I Approach
6
1. Life Cycle thinking approach, identification of relevant data and models
2. Development of the model graph
3. Development of the data graph
4. FAIRification of models / research software & Data
5. Definition of integrated mechanistic models of impact
6. Development of the Decision Support System & INSIGHT framework GUI
24th OECD WPMN
26th – 28th June 2024, Paris
A S S O C I A T E D P A R T N E R S ( I . E . ( A ) S W I S S P A R T N E R S A N D ( B ) U K P A R T N E R S )
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F O R E D U C A T I O N , R E S E A R C H A N D I N N O V A T I O N ( S E R I ) , A N D ( B ) I N N O V A T E U K .
T H E P I N K P R O J E C T H A S R E C E I V E D F U N D I N G F R O M T H E E U R O -
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PROVISION OF INTEGRATED COMPUTATIONAL
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MATERIALS
2 4 t h W o r k i n g P a r t y o n M a n u f a c t u r e d N a n o m a t e r i a l s ( W P M N )
2 6 t h – 2 8 t h J u n e 2 0 2 4 , P a r i s
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… integrating the
SSbD Framework
into the
development cycle
of AdMas&Chems
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The MACRAMÉ Project has received funding from:
Thank you
www.macrame-project.eu
The European Union’s Horizon Europe Research and
Innovation programme under grant agreement No.
101092686.
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MACRAMÉ-ChiPs: Patchwork Project Family & Sibling Projects (24th Meeting of the OECD WPMN)

  • 1. The MACRAMÉ project has received funding from the European Union’s Horizon Europe Research and Innovation programme under grant agreement No. 101092686. Associated Partners (i.e. (a) Swiss Partners and (b) UK Partners) have received national funding from (a) the Swiss State Secretariat for Education, Research and Innovation (SERI), and (b) Innovate UK. Patchwork Project Family & Sibling Projects – MACRAMÉ-ChIPs 24th Meeting of the OECD Working Party on Manufactured Nanomaterials (WPMN) 26th – 28th June 2024, Paris
  • 2. HORIZON-CL4-2023- RESILIENCE-01-21: Innovative methods for safety and sustainability assessments of chemicals and materials (RIA) HORIZON-CL4-2023- RESILIENCE-01-22: Integrated approach for impact assessment of safe and sustainable chemicals and materials (RIA) HORIZON-CL4-2023- RESILIENCE-01-23: Computational models for the development of safe and sustainable by design chemicals and materials (RIA) >>> decreasing Experimental (lab) work >>> >>> increasing in silico work >>> Sharing of Case-Studies of specific Chemicals & Materials Integration of shared computational Methods total budget: € 23.2 Mio. (ca. ¾ from EU, ¼ non-EU)  37 individual Research Institutions;  Jan. 2024 – Dec. 2027 24th OECD WPMN 26th – 28th June 2024, Paris
  • 3. The CHIASMA Project has received funding from: The European Union’s Horizon Europe Research and Innovation programme under grant agreement No. 101137613. ACCESSIBLE INNOVATIVE METHODS FOR THE SAFETY & SUSTAINABILITY ASSESSMENT OF CHEMICALS & MATERIALS 24th Working Party on Manufacture Nanomaterials (WPMN) 26th – 28th June 2024
  • 4. The CHIASMA R&I Approach 24th OECD WPMN 26th – 28th June 2024, Paris 4 Combining an iterative approach of: (1) chemocentric, (2) biocentric, and (3) new experimental models into a conceptual framework for data- integration and - processing. Illustration of the CHIASMA R&I approach to testing and assessment of materials.
  • 5. The INSIGHT Project has received funding from: The European Union’s Horizon Europe Research and Innovation programme under grant agreement No. 101137742. Funding Agency Australia Funding Agency USA Integrated Models for the Development and Assessment of High Impact Chemicals and Materials 24th OECDWorking Party on Manufactured Nanomaterials (WPMN) 26th – 28th June 2024, Paris
  • 6. R&I Approach 6 1. Life Cycle thinking approach, identification of relevant data and models 2. Development of the model graph 3. Development of the data graph 4. FAIRification of models / research software & Data 5. Definition of integrated mechanistic models of impact 6. Development of the Decision Support System & INSIGHT framework GUI 24th OECD WPMN 26th – 28th June 2024, Paris
  • 7. A S S O C I A T E D P A R T N E R S ( I . E . ( A ) S W I S S P A R T N E R S A N D ( B ) U K P A R T N E R S ) H A V E R E C E I V E D N A T I O N A L F U N D I N G F R O M ( A ) T H E S W I S S S T A T E S E C R E T A R I A T F O R E D U C A T I O N , R E S E A R C H A N D I N N O V A T I O N ( S E R I ) , A N D ( B ) I N N O V A T E U K . T H E P I N K P R O J E C T H A S R E C E I V E D F U N D I N G F R O M T H E E U R O - P E A N U N I O N ’ S H O R I Z O N E U R O P E R E S E A R C H A N D I N N O V A T I O N P R O G R A M M E U N D E R G R A N T A G R E E M E N T N O . 1 0 1 1 3 7 8 0 9 . PROVISION OF INTEGRATED COMPUTATIONAL APPROACHES FOR ADDRESSING NEW MARKET GOALS FOR THE INTRODUCTION OF SAFE-AND- SUSTAINABLE-BY-DESIGN CHEMICALS AND MATERIALS 2 4 t h W o r k i n g P a r t y o n M a n u f a c t u r e d N a n o m a t e r i a l s ( W P M N ) 2 6 t h – 2 8 t h J u n e 2 0 2 4 , P a r i s
  • 8. The PINK R&I Approach … integrating the SSbD Framework into the development cycle of AdMas&Chems 8 24th OECD WPMN 26th – 28th June 2024, Paris
  • 9. The MACRAMÉ Project has received funding from: Thank you www.macrame-project.eu The European Union’s Horizon Europe Research and Innovation programme under grant agreement No. 101092686. Steffi Friedrichs AcumenIST SRL Steffi@AcumenIST.com