Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership
Learn more about the Brazilian project that won silver medal in the 2014 iGEM synthetic biology in Boston / USA. A partnership between C.E.S.A.R and LIKA-UFPE.
5 Best Companies in Digital Pathology Market, March 2023
TissueGnostics GmbH provides streamlined solutions for both biomedical imaging and image analysis through its tissue cytometers. Founded by Dr. Rupert Ecker based on his experience in microscopy during his PhD, TissueGnostics aims to advance research on cells and tissues through precision automation. The company develops its own software and works with partners to provide open platforms like TissueFAXS and COLUBRIS Tissue Cytometer with AI. Through collaborative projects, TissueGnostics continues innovating to address diverse questions in tissue cytometry while maintaining high standards for research and clinical applications.
HealthBIO 2021_PerkinElmer, leading with innovation - from COVID success into...
This document provides an overview of PerkinElmer, a company focused on diagnostics, life sciences, food, and applied markets. It discusses their mission of innovating for a healthier world, with over 80 years of innovations including a COVID-19 PCR kit launched in 2020. The company's diagnostics segment focuses on reproductive health, immunoassays, and applied genomics. PerkinElmer has global capabilities across molecular diagnostics, imaging, automation, and more. It is pursuing growth in areas like single-cell analysis, therapeutics, digital solutions, and decentralized testing. The company's strategy focuses on detection, decentralization, and digitization to drive profitable growth.
National Genecular Institute (NGI) is establishing a large biobank called the BioTrust to advance research in personalized medicine. The BioTrust will collect and store biological samples like DNA, cells, tissue and blood, along with associated medical history data, to help researchers study complex diseases. NGI aims to collect over 15 million ethnically diverse samples to create one of the largest biological sample repositories in the world. By continuously updating the medical histories of donors, the BioTrust will provide researchers with a unique resource to study diseases and develop customized treatments tailored to individual genetics. NGI's biobank supports both its own research and drug development efforts as well as work by external scientists.
Status of the Microfluidics Industry 2019 report by Yole Développement
Diversification of microfluidic technologies has led to burgeoning new applications and market growth, driving players’ interest and M&A.
More information on https://www.i-micronews.com/products/status-of-the-microfluidics-industry-2019/
MediPi is a telehealth system developed by HSCIC to remotely monitor patients with chronic conditions through mobile devices in a secure, affordable way. It uses medical devices to measure vital signs and a simple interface for patients to complete daily questionnaires. Data is transmitted to clinicians who can message patients and access raw data through thresholds. Initial pilots focus on cardiac patients and costs £250 per patient, equivalent to savings of 4 nurse visits. MediPi is designed with open-source software and uses standards like Spine to securely and interoperably share data across clinical systems. HSCIC is looking to partner with NHS organizations to further test and develop MediPi clinically.
Building on the sell-out success of the launch event, SMi Group is delighted to announce the return of 3D Cell Culture, taking place on 21st and 22nd of February 2018, in London UK.
3D Cell Culture is rapidly growing with incredible potential for industrial application and a widespread reach that can be seen across many different fields, such as 3D bioprinting and microfluidics.
The 2nd annual conference will explore these overlapping areas and will combine pioneering breakthroughs with scientific research to strengthen your commercial success. Join us for exclusive insight into key topics such as disease models, organoids, organ-on-a-chip technologies, Ipsc advances and CRISPR technology. Notable speakers on the agenda for 2018 will include experts from Aurelia Bioscience, ReInnervate Ltd, Cell and Gene Therapy Catapult, University College London, Novartis Institutes for Biomedical Research, Kugelmeiers, GSK, AstraZeneca, Roche and more!
The new Biograph mCT from Siemens provides intelligently reproducible quantification through three key innovations:
1. Daily quality control scans normalize system performance to ensure consistent and accurate quantitative results over time.
2. Precise co-registration of PET and CT images through innovations like SMART registration technologies provide better attenuation correction for more reliable data.
3. Intelligent software applications in syngo.via like SUVpeak, myocardial blood flow quantification, and pending tools for neurology assist in standardized, reproducible interpretation across users and time.
Maximum Speed
Engineered Clinical
Flexibility
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
20
CPGR - Service provision, innovation eco-system creation, translational resea...
The CPGR provides genomic and proteomic services and conducts translational research and development. It was established in 2006 in Cape Town, South Africa to support the development of an internationally competitive bioeconomy. The CPGR maintains state-of-the-art genomic and proteomic technologies and bioinformatics capabilities to provide services and collaborate on research projects. It aims to stimulate life science innovation in Africa through creating an innovation ecosystem and building genomic and proteomic capacity.
This document discusses emerging trends in biotechnology, including artificial intelligence, big data, gene editing, precision medicine, gene sequencing, biomanufacturing, synthetic biology, bioprinting, microfluidics, and tissue engineering. It explains how these trends are enabling biotechnology startups to develop new medical products and therapies, scale operations, drive innovation, offer personalized treatment, and optimize bioprocessing. Gene editing techniques in particular allow for targeted gene modification and applications in gene therapy and transgenic organisms.
This document summarizes an agenda for a conference on genomic and cytogenetics research. It discusses:
1) Designing a genome-wide search for structural variants related to type 1 diabetes.
2) Ensuring the highest quality copy number variant results in genomic studies.
3) Updates on the International Standards for Cytogenomic Arrays consortium and database.
Patients with degenerative health issues need to constant monitor vital signs and important indexes in order to control their medication and act fast in case of emergency.
Online monitoring at all times through a medical network that connects the patient directly to the doctor with virtually no discomfort to the patient.
The document summarizes opportunities in the bio-medical industry in the South West region of the UK. It finds that the region has strengths in clinical research, diagnostics, medical devices, biosecurity, and bioinformatics. In particular, the region is a world leader in fields like oncology, neuroscience, and stem cell research. It also has a large presence of companies involved in manufacturing, distribution, diagnostics, and medical devices. The document analyzes opportunities in areas like nanotechnology applications, diagnostics, biosecurity, and bioinformatics and provides profiles of leading companies in each area. However, it notes regulatory and market uncertainties for some opportunities.
How AstraZeneca is Applying AI, Imaging & Data Analytics (AI-Driven Drug Deve...
Keynote AI Presentation given at AI-Driven Drug Development Summit Europe on 26th April 2023 in London. Overview around how AstraZeneca has been developing AI in the past 5+ years. Predominantly focused on R&D and how we are developing digital solutions & AI for right safety and right dose. AI examples include machine learning for safety assessment, augmenting digital pathology for image quantification & segmentation, understanding more about our drugs through advanced imaging modalities and first steps in applying AI for right dose - immunogenicity, adverse events and tolerability.
Genomics strategy and implementation in the NHS in England
Genome UK – State of the nation by Professor Dame Sue Hill, Chief Scientific Officer for England and NHS Genomics Programme Senior Responsible Officer.
Thomas Willkens-El impacto de las ciencias ómicas en la medicina, la nutrició...
El 29 de marzo de 2016 celebramos un Simposio Internacional sobre el 'Impacto de las ciencias ómicas en la medicina, nutrición y biotecnología'. Organizado por la Fundación Ramón Areces en colaboración con la Real Academia Nacional de Medicina y BioEuroLatina, abordó cómo un mejor conocimiento del genoma humano está permitiendo notables avances hacia una medicina de precisión.
The document discusses SLAS (Society for Laboratory Automation and Screening), its role in connecting the life sciences sector, and the importance of collaboration. Key points include:
- SLAS is an international professional society with over 16,000 members that aims to advance life sciences research through education, content, and connecting its community.
- The COVID-19 pandemic accelerated the need for lab automation and highlighted the importance of innovating research methods. It also increased openness to collaboration between sectors.
- In-person scientific conferences are critical for SLAS as they foster important interactions and idea sharing that virtual formats cannot replace.
- Collaboration between academia, industry, and government is key to accelerating
Reach New Audiences, Generate Better Leads.
Learn how AZoNetwork Webinar production takes care of all the most stressful aspects of creating an effective virtual event, leaving you to do what you do best: talk about your product and how it helps your target audience.
This podcast episode discusses several topics including the importance of role models in engineering on International Women in Engineering Day, growing a marketing department from the ground up, building relationships with prospects on social media, answering questions about social media content creation in science and engineering industries, applying neuroscience techniques to marketing messages, how CEOs use social media to enhance leadership, tips for growing a personal network, Google's E-A-T algorithm and featured snippets, how relationship marketing can provide short and long term opportunities, and the importance of B2B branding and experiences with managing a company rebrand.
Collaborative Team Recommendation for Skilled Users: Objectives, Techniques, ...
Collaborative team recommendation involves selecting users with certain skills to form a team who will, more likely than not, accomplish a complex task successfully. To automate the traditionally tedious and error-prone manual process of team formation, researchers from several scientific spheres have proposed methods to tackle the problem. In this tutorial, while providing a taxonomy of team recommendation works based on their algorithmic approaches to model skilled users in collaborative teams, we perform a comprehensive and hands-on study of the graph-based approaches that comprise the mainstream in this field, then cover the neural team recommenders as the cutting-edge class of approaches. Further, we provide unifying definitions, formulations, and evaluation schema. Last, we introduce details of training strategies, benchmarking datasets, and open-source tools, along with directions for future works.
Molecular biology of abiotic stress tolerence in plants
### Molecular Biology of Abiotic Stress Tolerance in Plants
Abiotic stress refers to the non-living environmental factors that can cause significant harm to plants, including drought, salinity, extreme temperatures, heavy metals, and oxidative stress. Understanding the molecular biology underlying abiotic stress tolerance is crucial for developing crops that can withstand these conditions, ensuring food security in the face of climate change and environmental degradation. Here, we explore the key molecular mechanisms, pathways, and genetic strategies plants use to cope with abiotic stress.
#### 1. Signal Perception and Transduction
**1.1. Signal Perception:**
Plants possess various sensors and receptors to detect abiotic stress signals. For instance, membrane-bound receptors such as receptor-like kinases (RLKs) and ion channels play critical roles in sensing changes in environmental conditions.
**1.2. Signal Transduction Pathways:**
Upon sensing abiotic stress, plants activate complex signal transduction pathways that involve:
- **Calcium Signaling:** Changes in cytosolic calcium levels act as secondary messengers. Calcium-binding proteins, such as calmodulins (CaMs) and calcineurin B-like proteins (CBLs), decode these signals and activate downstream responses.
- **Reactive Oxygen Species (ROS) Signaling:** ROS are produced under stress and function as signaling molecules. Controlled ROS production is crucial for activating defense mechanisms, while excessive ROS can cause cellular damage.
- **Mitogen-Activated Protein Kinase (MAPK) Cascades:** These cascades amplify the stress signal and regulate the expression of stress-responsive genes.
#### 2. Transcriptional Regulation
**2.1. Transcription Factors (TFs):**
TFs are pivotal in regulating the expression of genes involved in stress responses. Key TF families include:
- **AP2/ERF (APETALA2/ETHYLENE RESPONSE FACTOR):** Involved in drought and salinity tolerance.
- **NAC (NAM, ATAF, and CUC):** Play roles in responding to dehydration and high salinity.
- **bZIP (Basic Leucine Zipper):** Associated with responses to various stresses, including drought and oxidative stress.
- **WRKY:** Participate in the regulation of genes involved in stress responses and pathogen defense.
**2.2. Epigenetic Regulation:**
Epigenetic modifications, such as DNA methylation, histone modifications, and chromatin remodeling, influence gene expression without altering the DNA sequence. These modifications can lead to the activation or repression of stress-responsive genes.
#### 3. Stress-Responsive Genes and Proteins
**3.1. Osmoprotectants:**
Plants accumulate osmoprotectants like proline, glycine betaine, and sugars (e.g., trehalose) to maintain cellular osmotic balance under stress conditions.
**3.2. Antioxidant Defense:**
To mitigate oxidative stress, plants enhance the production of antioxidants, such as superoxide dismutase (SOD), catalase (CAT), and peroxidases, which scavenge harmful ROS.
A mature quasar at cosmic dawn revealed by JWST rest-frame infrared spectroscopy
The rapid assembly of the first supermassive black holes is an enduring mystery. Until now, it was not known whether quasar ‘feeding’ structures (the ‘hot torus’) could assemble as fast as the smaller-scale quasar structures. We present JWST/MRS (rest-frame infrared) spectroscopic observations of the quasar J1120+0641 at z = 7.0848 (well within the epoch of reionization). The hot torus dust was clearly detected at λrest ≃ 1.3 μm, with a black-body temperature of
K, slightly elevated compared to similarly luminous quasars at lower redshifts. Importantly, the supermassive black hole mass of J1120+0641 based on the Hα line (accessible only with JWST), MBH = 1.52 ± 0.17 × 109 M⊙, is in good agreement with previous ground-based rest-frame ultraviolet Mg II measurements. Comparing the ratios of the Hα, Paα and Paβ emission lines to predictions from a simple one-phase Cloudy model, we find that they are consistent with originating from a common broad-line region with physical parameters that are consistent with lower-redshift quasars. Together, this implies that J1120+0641’s accretion structures must have assembled very quickly, as they appear fully ‘mature’ less than 760 Myr after the Big Bang.
Hydrogen sulfide and metal-enriched atmosphere for a Jupiter-mass exoplanet
We observed two transits of HD 189733b in JWST program 1633 using JWST
NIRCam grism F444W and F322W2 filters on August 25 and 29th 2022. The first
visit with F444W used SUBGRISM64 subarray lasting 7877 integrations with 4
BRIGHT1 groups per integration. Each effective integration is 2.4s for a total effective exposure time of 18780.9s and a total exposure duration of 21504.2s (∼6 hrs)
including overhead. The second visit with F322W2 used SUBGRISM64 subarray
lasting 10437 integrations with 3 BRIGHT1 groups per integration. Each effective
integration is 1.7s for a total effective exposure time of 17774.7s and a total exposure
duration of 21383.1s (∼6 hrs) including overhead. The transit duration of HD189733
b is ∼1.8 hrs and both observations had additional pre-ingress baseline relative to
post-egress baseline in anticipating the potential ramp systematics at the beginning
of the exposure from NIRCam infrared detectors.
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Emerging healthcare solution providers in 2019 compressed (1)insightscare
In this special issue of ‘Emerging Healthcare Solution Providers to Watch in 2019’, we have enlightened the foremost Healthcare Solution Providers that are transforming the healthcare industry with their astounding services and approaches.
Future Diagnostics, In Vitro Diagnostiek "Bloedserieus"Health Valley
Future Diagnostics strives to become a leading developer of innovative diagnostic tests. It aims to be the preferred partner of top IVD companies for outsourced test development. The company was founded in 1997 and now has 60 employees working on 34 projects. It has two facilities and is certified under ISO and FDA quality standards. Future Diagnostics has experience developing assays for various analytes on automated platforms and is interested in point-of-care tests and new testing technologies.
Biosensor for Early Detection of Breast Cancer - LIKA-CESAR PartnershipCESAR
Learn more about the Brazilian project that won silver medal in the 2014 iGEM synthetic biology in Boston / USA. A partnership between C.E.S.A.R and LIKA-UFPE.
5 Best Companies in Digital Pathology Market, March 2023insightscare
TissueGnostics GmbH provides streamlined solutions for both biomedical imaging and image analysis through its tissue cytometers. Founded by Dr. Rupert Ecker based on his experience in microscopy during his PhD, TissueGnostics aims to advance research on cells and tissues through precision automation. The company develops its own software and works with partners to provide open platforms like TissueFAXS and COLUBRIS Tissue Cytometer with AI. Through collaborative projects, TissueGnostics continues innovating to address diverse questions in tissue cytometry while maintaining high standards for research and clinical applications.
HealthBIO 2021_PerkinElmer, leading with innovation - from COVID success into...Business Turku
This document provides an overview of PerkinElmer, a company focused on diagnostics, life sciences, food, and applied markets. It discusses their mission of innovating for a healthier world, with over 80 years of innovations including a COVID-19 PCR kit launched in 2020. The company's diagnostics segment focuses on reproductive health, immunoassays, and applied genomics. PerkinElmer has global capabilities across molecular diagnostics, imaging, automation, and more. It is pursuing growth in areas like single-cell analysis, therapeutics, digital solutions, and decentralized testing. The company's strategy focuses on detection, decentralization, and digitization to drive profitable growth.
National Genecular Institute (NGI) is establishing a large biobank called the BioTrust to advance research in personalized medicine. The BioTrust will collect and store biological samples like DNA, cells, tissue and blood, along with associated medical history data, to help researchers study complex diseases. NGI aims to collect over 15 million ethnically diverse samples to create one of the largest biological sample repositories in the world. By continuously updating the medical histories of donors, the BioTrust will provide researchers with a unique resource to study diseases and develop customized treatments tailored to individual genetics. NGI's biobank supports both its own research and drug development efforts as well as work by external scientists.
Status of the Microfluidics Industry 2019 report by Yole Développement Yole Developpement
Diversification of microfluidic technologies has led to burgeoning new applications and market growth, driving players’ interest and M&A.
More information on https://www.i-micronews.com/products/status-of-the-microfluidics-industry-2019/
MediPi is a telehealth system developed by HSCIC to remotely monitor patients with chronic conditions through mobile devices in a secure, affordable way. It uses medical devices to measure vital signs and a simple interface for patients to complete daily questionnaires. Data is transmitted to clinicians who can message patients and access raw data through thresholds. Initial pilots focus on cardiac patients and costs £250 per patient, equivalent to savings of 4 nurse visits. MediPi is designed with open-source software and uses standards like Spine to securely and interoperably share data across clinical systems. HSCIC is looking to partner with NHS organizations to further test and develop MediPi clinically.
Building on the sell-out success of the launch event, SMi Group is delighted to announce the return of 3D Cell Culture, taking place on 21st and 22nd of February 2018, in London UK.
3D Cell Culture is rapidly growing with incredible potential for industrial application and a widespread reach that can be seen across many different fields, such as 3D bioprinting and microfluidics.
The 2nd annual conference will explore these overlapping areas and will combine pioneering breakthroughs with scientific research to strengthen your commercial success. Join us for exclusive insight into key topics such as disease models, organoids, organ-on-a-chip technologies, Ipsc advances and CRISPR technology. Notable speakers on the agenda for 2018 will include experts from Aurelia Bioscience, ReInnervate Ltd, Cell and Gene Therapy Catapult, University College London, Novartis Institutes for Biomedical Research, Kugelmeiers, GSK, AstraZeneca, Roche and more!
The new Biograph mCT from Siemens provides intelligently reproducible quantification through three key innovations:
1. Daily quality control scans normalize system performance to ensure consistent and accurate quantitative results over time.
2. Precise co-registration of PET and CT images through innovations like SMART registration technologies provide better attenuation correction for more reliable data.
3. Intelligent software applications in syngo.via like SUVpeak, myocardial blood flow quantification, and pending tools for neurology assist in standardized, reproducible interpretation across users and time.
Maximum Speed
Engineered Clinical
Flexibility
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
20
CPGR - Service provision, innovation eco-system creation, translational resea...Reinhard Hiller
The CPGR provides genomic and proteomic services and conducts translational research and development. It was established in 2006 in Cape Town, South Africa to support the development of an internationally competitive bioeconomy. The CPGR maintains state-of-the-art genomic and proteomic technologies and bioinformatics capabilities to provide services and collaborate on research projects. It aims to stimulate life science innovation in Africa through creating an innovation ecosystem and building genomic and proteomic capacity.
This document discusses emerging trends in biotechnology, including artificial intelligence, big data, gene editing, precision medicine, gene sequencing, biomanufacturing, synthetic biology, bioprinting, microfluidics, and tissue engineering. It explains how these trends are enabling biotechnology startups to develop new medical products and therapies, scale operations, drive innovation, offer personalized treatment, and optimize bioprocessing. Gene editing techniques in particular allow for targeted gene modification and applications in gene therapy and transgenic organisms.
This document summarizes an agenda for a conference on genomic and cytogenetics research. It discusses:
1) Designing a genome-wide search for structural variants related to type 1 diabetes.
2) Ensuring the highest quality copy number variant results in genomic studies.
3) Updates on the International Standards for Cytogenomic Arrays consortium and database.
Patients with degenerative health issues need to constant monitor vital signs and important indexes in order to control their medication and act fast in case of emergency.
Online monitoring at all times through a medical network that connects the patient directly to the doctor with virtually no discomfort to the patient.
The document summarizes opportunities in the bio-medical industry in the South West region of the UK. It finds that the region has strengths in clinical research, diagnostics, medical devices, biosecurity, and bioinformatics. In particular, the region is a world leader in fields like oncology, neuroscience, and stem cell research. It also has a large presence of companies involved in manufacturing, distribution, diagnostics, and medical devices. The document analyzes opportunities in areas like nanotechnology applications, diagnostics, biosecurity, and bioinformatics and provides profiles of leading companies in each area. However, it notes regulatory and market uncertainties for some opportunities.
How AstraZeneca is Applying AI, Imaging & Data Analytics (AI-Driven Drug Deve...Nick Brown
Keynote AI Presentation given at AI-Driven Drug Development Summit Europe on 26th April 2023 in London. Overview around how AstraZeneca has been developing AI in the past 5+ years. Predominantly focused on R&D and how we are developing digital solutions & AI for right safety and right dose. AI examples include machine learning for safety assessment, augmenting digital pathology for image quantification & segmentation, understanding more about our drugs through advanced imaging modalities and first steps in applying AI for right dose - immunogenicity, adverse events and tolerability.
Genome UK – State of the nation by Professor Dame Sue Hill, Chief Scientific Officer for England and NHS Genomics Programme Senior Responsible Officer.
Thomas Willkens-El impacto de las ciencias ómicas en la medicina, la nutrició...Fundación Ramón Areces
El 29 de marzo de 2016 celebramos un Simposio Internacional sobre el 'Impacto de las ciencias ómicas en la medicina, nutrición y biotecnología'. Organizado por la Fundación Ramón Areces en colaboración con la Real Academia Nacional de Medicina y BioEuroLatina, abordó cómo un mejor conocimiento del genoma humano está permitiendo notables avances hacia una medicina de precisión.
Similar to MGI Sequencing and Genomics. Elevanting Science and Healthcare (20)
The document discusses SLAS (Society for Laboratory Automation and Screening), its role in connecting the life sciences sector, and the importance of collaboration. Key points include:
- SLAS is an international professional society with over 16,000 members that aims to advance life sciences research through education, content, and connecting its community.
- The COVID-19 pandemic accelerated the need for lab automation and highlighted the importance of innovating research methods. It also increased openness to collaboration between sectors.
- In-person scientific conferences are critical for SLAS as they foster important interactions and idea sharing that virtual formats cannot replace.
- Collaboration between academia, industry, and government is key to accelerating
Reach New Audiences, Generate Better Leads.
Learn how AZoNetwork Webinar production takes care of all the most stressful aspects of creating an effective virtual event, leaving you to do what you do best: talk about your product and how it helps your target audience.
This podcast episode discusses several topics including the importance of role models in engineering on International Women in Engineering Day, growing a marketing department from the ground up, building relationships with prospects on social media, answering questions about social media content creation in science and engineering industries, applying neuroscience techniques to marketing messages, how CEOs use social media to enhance leadership, tips for growing a personal network, Google's E-A-T algorithm and featured snippets, how relationship marketing can provide short and long term opportunities, and the importance of B2B branding and experiences with managing a company rebrand.
Collaborative Team Recommendation for Skilled Users: Objectives, Techniques, ...Hossein Fani
Collaborative team recommendation involves selecting users with certain skills to form a team who will, more likely than not, accomplish a complex task successfully. To automate the traditionally tedious and error-prone manual process of team formation, researchers from several scientific spheres have proposed methods to tackle the problem. In this tutorial, while providing a taxonomy of team recommendation works based on their algorithmic approaches to model skilled users in collaborative teams, we perform a comprehensive and hands-on study of the graph-based approaches that comprise the mainstream in this field, then cover the neural team recommenders as the cutting-edge class of approaches. Further, we provide unifying definitions, formulations, and evaluation schema. Last, we introduce details of training strategies, benchmarking datasets, and open-source tools, along with directions for future works.
Molecular biology of abiotic stress tolerence in plantsrushitahakik1
### Molecular Biology of Abiotic Stress Tolerance in Plants
Abiotic stress refers to the non-living environmental factors that can cause significant harm to plants, including drought, salinity, extreme temperatures, heavy metals, and oxidative stress. Understanding the molecular biology underlying abiotic stress tolerance is crucial for developing crops that can withstand these conditions, ensuring food security in the face of climate change and environmental degradation. Here, we explore the key molecular mechanisms, pathways, and genetic strategies plants use to cope with abiotic stress.
#### 1. Signal Perception and Transduction
**1.1. Signal Perception:**
Plants possess various sensors and receptors to detect abiotic stress signals. For instance, membrane-bound receptors such as receptor-like kinases (RLKs) and ion channels play critical roles in sensing changes in environmental conditions.
**1.2. Signal Transduction Pathways:**
Upon sensing abiotic stress, plants activate complex signal transduction pathways that involve:
- **Calcium Signaling:** Changes in cytosolic calcium levels act as secondary messengers. Calcium-binding proteins, such as calmodulins (CaMs) and calcineurin B-like proteins (CBLs), decode these signals and activate downstream responses.
- **Reactive Oxygen Species (ROS) Signaling:** ROS are produced under stress and function as signaling molecules. Controlled ROS production is crucial for activating defense mechanisms, while excessive ROS can cause cellular damage.
- **Mitogen-Activated Protein Kinase (MAPK) Cascades:** These cascades amplify the stress signal and regulate the expression of stress-responsive genes.
#### 2. Transcriptional Regulation
**2.1. Transcription Factors (TFs):**
TFs are pivotal in regulating the expression of genes involved in stress responses. Key TF families include:
- **AP2/ERF (APETALA2/ETHYLENE RESPONSE FACTOR):** Involved in drought and salinity tolerance.
- **NAC (NAM, ATAF, and CUC):** Play roles in responding to dehydration and high salinity.
- **bZIP (Basic Leucine Zipper):** Associated with responses to various stresses, including drought and oxidative stress.
- **WRKY:** Participate in the regulation of genes involved in stress responses and pathogen defense.
**2.2. Epigenetic Regulation:**
Epigenetic modifications, such as DNA methylation, histone modifications, and chromatin remodeling, influence gene expression without altering the DNA sequence. These modifications can lead to the activation or repression of stress-responsive genes.
#### 3. Stress-Responsive Genes and Proteins
**3.1. Osmoprotectants:**
Plants accumulate osmoprotectants like proline, glycine betaine, and sugars (e.g., trehalose) to maintain cellular osmotic balance under stress conditions.
**3.2. Antioxidant Defense:**
To mitigate oxidative stress, plants enhance the production of antioxidants, such as superoxide dismutase (SOD), catalase (CAT), and peroxidases, which scavenge harmful ROS.
A mature quasar at cosmic dawn revealed by JWST rest-frame infrared spectroscopySérgio Sacani
The rapid assembly of the first supermassive black holes is an enduring mystery. Until now, it was not known whether quasar ‘feeding’ structures (the ‘hot torus’) could assemble as fast as the smaller-scale quasar structures. We present JWST/MRS (rest-frame infrared) spectroscopic observations of the quasar J1120+0641 at z = 7.0848 (well within the epoch of reionization). The hot torus dust was clearly detected at λrest ≃ 1.3 μm, with a black-body temperature of
K, slightly elevated compared to similarly luminous quasars at lower redshifts. Importantly, the supermassive black hole mass of J1120+0641 based on the Hα line (accessible only with JWST), MBH = 1.52 ± 0.17 × 109 M⊙, is in good agreement with previous ground-based rest-frame ultraviolet Mg II measurements. Comparing the ratios of the Hα, Paα and Paβ emission lines to predictions from a simple one-phase Cloudy model, we find that they are consistent with originating from a common broad-line region with physical parameters that are consistent with lower-redshift quasars. Together, this implies that J1120+0641’s accretion structures must have assembled very quickly, as they appear fully ‘mature’ less than 760 Myr after the Big Bang.
Hydrogen sulfide and metal-enriched atmosphere for a Jupiter-mass exoplanetSérgio Sacani
We observed two transits of HD 189733b in JWST program 1633 using JWST
NIRCam grism F444W and F322W2 filters on August 25 and 29th 2022. The first
visit with F444W used SUBGRISM64 subarray lasting 7877 integrations with 4
BRIGHT1 groups per integration. Each effective integration is 2.4s for a total effective exposure time of 18780.9s and a total exposure duration of 21504.2s (∼6 hrs)
including overhead. The second visit with F322W2 used SUBGRISM64 subarray
lasting 10437 integrations with 3 BRIGHT1 groups per integration. Each effective
integration is 1.7s for a total effective exposure time of 17774.7s and a total exposure
duration of 21383.1s (∼6 hrs) including overhead. The transit duration of HD189733
b is ∼1.8 hrs and both observations had additional pre-ingress baseline relative to
post-egress baseline in anticipating the potential ramp systematics at the beginning
of the exposure from NIRCam infrared detectors.
ScieNCE grade 08 Lesson 1 and 2 NLC.pptxJoanaBanasen1
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TOPIC: INTRODUCTION TO FORENSIC SCIENCE.pptximansiipandeyy
This presentation, "Introduction to Forensic Science," offers a basic understanding of forensic science, including its history, why it's needed, and its main goals. It covers how forensic science helps solve crimes and its importance in the justice system. By the end, you'll have a clear idea of what forensic science is and why it's essential.
Keys of Identification for Indian Wood: A Seminar ReportGurjant Singh
Identifying Indian wood involves recognizing key characteristics such as grain patterns, color, texture, hardness, and specific anatomical features. These identification keys include observing the wood's pores, growth rings, and resin canals, as well as its scent and weight. Understanding these features is essential for accurate wood identification, which is crucial for various applications in carpentry, furniture making, and conservation.
Additionally, the application of Convolutional Neural Networks (CNN) in wood identification has revolutionized this field. CNNs can analyze images of wood samples to identify species with high accuracy by learning and recognizing intricate patterns and features. This technological advancement not only enhances the precision of wood identification but also accelerates the process, making it more efficient for industry professionals and researchers alike.
El Nuevo Cohete Ariane de la Agencia Espacial Europea-6_Media-Kit_english.pdfChamps Elysee Roldan
Europe must have autonomous access to space to realise its ambitions on the world stage and
promote knowledge and prosperity.
Space is a natural extension of our home planet and forms an integral part of the infrastructure
that is vital to daily life on Earth. Europe must assert its rightful place in space to ensure its
citizens thrive.
As the world’s second-largest economy, Europe must ensure it has secure and autonomous access to
space, so it does not depend on the capabilities and priorities of other nations.
Europe’s longstanding expertise in launching spacecraft and satellites has been a driving force behind
its 60 years of successful space cooperation.
In a world where everyday life – from connectivity to navigation, climate and weather – relies on
space, the ability to launch independently is more important than ever before. With the launch of
Ariane 6, Europe is not just sending a rocket into the sky, we are asserting our place among the
world’s spacefaring nations.
ESA’s Ariane 6 rocket succeeds Ariane 5, the most dependable and competitive launcher for decades.
The first Ariane rocket was launched in 1979 from Europe’s Spaceport in French Guiana and Ariane 6 will continue the adventure.
Putting Europe at the forefront of space transportation for nearly 45 years, Ariane is a triumph of engineering and the prize of great European industrial and political
cooperation. Ariane 1 gave way to more powerful versions 2, 3 and 4. Ariane 5 served as one of the world’s premier heavy-lift rockets, putting single or multiple
payloads into orbit – the cargo and instruments being launched – and sent a series of iconic scientific missions to deep space.
The decision to start developing Ariane 6 was taken in 2014 to respond to the continued need to have independent access to space, while offering efficient
commercial launch services in a fast-changing market.
ESA, with its Member States and industrial partners led by ArianeGroup, is developing new technologies for new markets with Ariane 6. The versatility of Ariane 6
adds a whole new dimension to its very successful predecessors
The cryptoterrestrial hypothesis: A case for scientific openness to a conceal...Sérgio Sacani
Recent years have seen increasing public attention and indeed concern regarding Unidentified
Anomalous Phenomena (UAP). Hypotheses for such phenomena tend to fall into two classes: a
conventional terrestrial explanation (e.g., human-made technology), or an extraterrestrial explanation
(i.e., advanced civilizations from elsewhere in the cosmos). However, there is also a third minority
class of hypothesis: an unconventional terrestrial explanation, outside the prevailing consensus view of
the universe. This is the ultraterrestrial hypothesis, which includes as a subset the “cryptoterrestrial”
hypothesis, namely the notion that UAP may reflect activities of intelligent beings concealed in stealth
here on Earth (e.g., underground), and/or its near environs (e.g., the moon), and/or even “walking
among us” (e.g., passing as humans). Although this idea is likely to be regarded sceptically by most
scientists, such is the nature of some UAP that we argue this possibility should not be summarily
dismissed, and instead deserves genuine consideration in a spirit of epistemic humility and openness.
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Testing the Son of God Hypothesis (Jesus Christ)Robert Luk
Instead of answering the God hypothesis, we investigate the Son of God hypothesis. We developed our own methodology to deal with existential statements instead of universal statements unlike science. We discuss the existence of the supernaturals and found that there are strong evidence for it. Given that supernatural exists, we report on miracles investigated in the past related to the Son of God. A Bayesian methodology is used to calculate the combined degree of belief of the Son of God Hypothesis. We also report the testing of occurrences of words/numbers in the Bible to suggest the likelihood of some special numbers occurring, supporting the Son of God Hypothesis. We also have a table showing the past occurrences of miracles in hundred year periods for about 1000 years. Miracles that we have looked at include Shroud of Turin, Eucharistic Miracles, Marian Apparitions, Incorruptible Corpses, etc.
MGI Sequencing and Genomics. Elevanting Science and Healthcare
1. Elevating Science and Healthcare: MGI’s DNBSEQ™
Technology Across Diverse Frontiers
SEQUENCING & GENOMICS
2. MGI Tech Co., Ltd. (referred to as MGI) is committed to building core tools
and technology to lead life science through intelligent innovation. With a
focus on R&D, production and sales of DNA sequencing instruments,
reagents, and related products, MGI provides real-time, panoramic, and life
course equipment and systems for precision medicine, precision agriculture,
precision healthcare and other relevant industries. MGI is a leading producer
of clinical high-throughput gene sequencers, and its multi-omics platforms
include genetic sequencing, medical imaging, and laboratory automation.
As of September 30, 2023, MGI has more than 2,900 employees, and 36%
of whom are R&D personnel. Founded in 2016, MGI operates in more than
100 countries and regions, serving more than 2,600 customers. It has
established scientific research and production bases, global training and
service network in many countries and regions around the world. MGI is one
of the few companies in the world that can independently develop and
mass-produce low-, medium- and high-throughput clinical gene sequencers
from GB to TB. Providing real-time, comprehensive, life course solutions, its
vision is to lead life science innovation.
About MGI
VISION
MISSION
Leading Life Science Innovation
To Develop and Promote Advanced Life Science Tools for Future Healthcare
Find Out More
3. Contents
02
MGI's DNBSEQ™ Sequencing Across Diverse Applications
MGI improves agriculture globally with accessible genetic sequencing
solutions
Enhancing medical access in rural areas with pioneering remote robotic
ultrasound technology
From Sanger Sequencing to the Human Genome Project: The Evolution of
DNA Sequencing Technology
MGI demonstrates comprehensive initiatives in infectious disease monitoring
and control
08
How do De novo sequencing, QTL mapping, WGS, and lcWGS empower
breakthroughs in agrigenomics
12
UNIQUE SEQUENCING TECHNOLOGY
AGRIGENOMICS
40
MGI breaks down barriers in population genomics with comprehensive
end-to-end genomic solutions
POPULATION GENOMICS
PANDEMIC RESPONSE
36
Partnering with Gene+ to Provide Accessible, High-Quality Oncology
Solutions
PRECISION ONCOLOGY
30
Revolutionizing Genomics Research: MGI’s DNBSEQ™ Sequencing
Solutions Break Barriers and Achieve Research Goals
METAGENOMIC RESEARCH
34 MGI’s DNBSEQ-T7* facilitates ultra-deep sequencing of high-complexity
metagenomic samples
CUTTING-EDGE MEDICAL PLATFORM
03
17
21
4. 03
MGI's DNBSEQ™ Sequencing Across Diverse Applications
Revolutionizing Genomics Research:
MGI’s DNBSEQ™ Sequencing
Solutions Break Barriers and
Achieve Research Goals
UNIQUE SEQUENCING TECHNOLOGY
Next-generation sequencing (NGS) is an evolving field that has revolutionized genomics research
in various disciplines and is propelling the use of genomics for the greater good. MGI is one of
few companies to offer whole workflow solution with one-stop-shop, real-time, for whatever the
genetic sequencing needs. MGI’s DNBSEQ™ platforms feature high throughput technology,
transforming sequencing projects in all realms of research.
5. 04
MGI's DNBSEQ™ Sequencing Across Diverse Applications
Next-generation sequencing - Achieving all research goals
Since its dawn in the early 2000s, NGS has reformed how researchers read genetic codes,
enabling faster and more precise sequencing. NGS advances in various disciplines, including
population genomics, biodiversity, agricultural genomics, and clinical genomics. With much
higher sensitivity in detecting low-frequency variants, NGS is especially important in the diagno-
sis and treatment of rare diseases through precision medicine.
MGI launched the first DNBSEQ™ platform in 2015 and through the 8 years’ innovation, it now
offers an extensive product portfolio of ultra-high-, high- and medium-throughput sequencers,
accommodating all sequencing needs with accessibility and affordability. MGI’s expertise
enables researchers to attain their goals and push their research and development to the next
level.
What if cost was not a barrier?
A drawback that has limited accessibility to genetic sequencing has been the financial barrier
associated with the required computational power, data storage, and labor time. Reducing these
costs is paramount to unlocking the full potential of NGS and allowing more research sectors
across the globe to utilize the technologies. MGI is committed to removing the barrier through
continuous technology innovation.
The DNBSEQ-T20×2*.
6. Partnering with the South Australian Genomics Centre, MGI introduced this ultra-high throughput
sequencer for commercial use for the first time in Australia. In Brazil, MGI is supporting Pens-
abio’s large national genomic sequencing project, which aims to sequence the complete
genomes of thousands of patients with rare diseases and hereditary cancers. This project will
identify genetic markers that can be tracked for important early diagnosis and treatment.
05
MGI's DNBSEQ™ Sequencing Across Diverse Applications
In 2022, MGI broke the $100 genome barrier by launching the ultra-high throughput sequencer
DNBSEQ-T20×2*. This single set can produce up to 50,000 whole-genome sequences (WGS) in
one year per 30x human genomes, making NGS much more accessible to researchers globally.
Utilizing advanced dip-immersion biochemistry, two imagers, and a rotational, robotic handling
arm, one DNBSEQ-T20×2* sequencer can assay six slides simultaneously. This can provide 42
Tb of data per run with PE100 and up to 72 Tb per run with PE150. With DNBSEQ-T20×2*, MGI
can now produce the highest throughput per run with high quality sequencing data.
Trade-offs between speed, low cost, and flexibility
MGI also recognizes the trade-offs that arise when reducing costs, such as reduced speed and
flexibility. MGI’s DNBSEQ-T7* sequencer addresses these trade-offs, providing researchers with
great flexibility. The sequencer has various applications in agriculture, multi-omics, precision
medicine, metagenomics, biodiversity etc. This sequencer has been supporting customers across
the globe in places such as Thailand, Indonesia, and Brazil, aiding in major national genome
projects.
The DNBSEQ-T7*.
7. DNBSEQ-T7* is supporting the Genomics Thailand Initiative to increase the country’s
competitiveness and put them on the map in genomic medical research, improving medicine
management standards for its citizens. It is also assisting the Ministry of Health in Indonesia with
its National Genome Project, working towards establishing a precise, credible population
database of 10,000 genomes for medical research.
With this sequencer, researchers in both developed and developing nations can conduct
large-scale genomics studies without encountering trade-offs on performance. MGI can help
researchers accomplish a genomics project at any scale.
Right targeted sequencing within 24 hours
When it comes to disease diagnosis and treatment, time is precious, as faster diagnosis means
faster treatment. Delivering the correct targeted therapy to patients in a reduced time frame is
vital in increasing patient survival rates.
Thanks to one of our most recent sequencers, DNBSEQ-G99*, MGI delivers targeted
sequencing results as quickly as 24 hours.
06
MGI's DNBSEQ™ Sequencing Across Diverse Applications
DNBSEQ-G99*, offers mid- to low-throughput assays
at an ultra-high speed, perfect for targeting specific
gene sequences and for small genome sequencing.
With a triangular matrix of single spots on the
sequencing flow cell and highly precise temperature
control, the DNBSEQ-G99* platform gives a greater
data output density in a shorter time with an overall
throughput of 8-48 Gb per run.
The turnaround time of a PE150 sequencing run is
shortened to a groundbreaking 12 hours, meaning
the pathology labs could potentially assign the right
targeted therapy to a patient by the end of the day.
The DNBSEQ-G99*.
DNBSEQ-G99* was central to the diagnosis of the first imported case of monkeypox to mainland
China in 2022, allowing a quick response to taking the necessary actions to control the disease
outbreak.5 Faster diagnosis of diseases like monkeypox allows for quicker development of
vaccines to manage the spread of diseases much earlier on.
8. 07
What if there was a company that understands all your needs when it
comes to genomics research?
Although MGI is significantly advanced in its sequencers and focused on continuing to break
down the financial barriers associated with them – offering an extensive product portfolio of
ultra-high-, high-, and medium-throughput sequencers to accommodate different sequencing
needs at a competitive cost – the company realizes that research goes further than sequencing
genetic data.
MGI offers a one-stop-shop solution for research that includes lab automation, single-cell
platforms, BIT platforms, and a lab information management system and data management
system. MGI continues to provide laboratories across the globe with the most cutting-edge
genomic techniques with accessibility and affordability.
MGI's DNBSEQ™ Sequencing Across Diverse Applications
References and Further Reading
For more information, please visit: http://mgi-whatif.com/
- MGI and South Australian Genomics Centre introduce DNBSEQ-T7 to supercharge genomics
research in Australia (2023) MGI. Available at: https://en.mgi-tech.com/news/caseinfo/92/
- MGI supports a national genomic sequencing project that aims to build the largest genetic
database in Brazil (2023) MGI. Available at: https://en.mgi-tech.com/news/caseinfo/87/
- MGI contributes to Thailand’s roadmap for Genomic Medicine in Genomics Thailand initiative
(2023) MGI. Available at: https://en.mgi-tech.com/news/caseinfo/78/
- MGI supports the Ministry of Health of Indonesia in the country’s breakthrough National
Genome Project (2023) MGI. Available at: https://en.mgi-tech.com/news/caseinfo/76/
- Zhao, H., Wang, W., Zhao, L., Ye, S., Song, J., Lu, R., Zong, H., Wu, C., Huang, W., Huang, B.
and Deng, Y. 2022. The first imported case of monkeypox in the mainland of
China—Chongqing municipality, China, September 16, 2022. China C
9. 08
MGI's DNBSEQ™ Sequencing Across Diverse Applications
MGI improves agriculture globally
with accessible genetic
sequencing solutions
AGRIGENOMICS
With advances in agrigenomics, scientists have successfully improved a large number of crops
varieties by using genetic resources and innovative breeding solutions. To accelerate the
breeding and improvement of crops globally, MGI has long played a part in providing agricultural
scientists and breeders alike with high-quality and accessible genomics tools and solutions to
promote genome sequencing and genotyping research and facilitate the construction and
improvement of agrigenomics databases.
According to the Food and Agriculture Organization of the United Nations, we will need to
produce 50% more food by 2050 to feed an estimated 9 billion people if the planet’s population
continues to grow at its current speed. At the same time, crop yields have been forecasted to
decrease by over 25% as weather patterns become more extreme, further weakening an
already-fragile global food system.
Given the changing climate, expanding population, and increasing demands for nutrition, the
application of modern genomics tools to agriculture is of fundamental importance. By applying
genomics technologies to the breeding and management of crops, researchers can develop
more resilient crops and new varieties to improve sustainability. To this end, high throughput
sequencing has become indispensable for breeding practices.
However, there are many challenges that lie ahead in the wider application of agrigenomics.
Dealing with agrigenomics data that is extremely large in scale and highly repetitive requires
ultra-high accuracy and efficiency, and most importantly, high cost-effectiveness. In developing
countries where agriculture is an important way of life for millions of small-scale households, the
lack of access to improved seeds and advanced technology can mean lower resilience in face of
weather-related disasters, driving many rural families into dire circumstances.
10. 09
MGI's DNBSEQ™ Sequencing Across Diverse Applications
Leveraging MGI’s cutting-edge technologies, scientists today can have access to highly
accurate, accessible and efficient sequencers* to further their research, uncover the full potential
of agrigenomics and become one step closer to ending world hunger. Aimed at producing more
resilient and sustainable food systems across the continent, the African BioGenome Project
(AfricaBP) sets off to sequence 100,000 endemic African species within the next ten years with
help from MGI. Utilizing MGI’s single-tube long fragment read (stLFR) technology, the project
recently saw its first plant species being sequenced and will continue towards building a full
genomic database for the benefit of African scientists and breeders.
Elsewhere in Australia, Professor Rajeev Varshney, Fellow of the Royal Society and Director of
Centre for Crop and Food Innovation at Murdoch University (MU) and a strong advocate for
MGI, has been using the core DNBSEQ™ technology and its relevant tools for over seven years,
citing various advantages including high accuracy, decreased duplicates, and extreme low index
hopping rate in a wide range of past innovative agriculture projects that tackled food security
issues in the developing world.
In an effort to improve yields of chickpea, one of the most important and low-cost sources of
protein, as well as a rich source of many micro-nutrients and fiber, Prof. Varshney sequenced
429 chickpea lines from 45 countries to identify genes for drought tolerance and disease
resistance. With these key insights and findings, scientists can improve breeding applications
through the crop’s genetic diversity, domestication and agronomic traits. Later in 2021, he led the
sequencing and mapping of 3,366 chickpea genomes, thereby providing a deeper
understanding of the chickpea genome and accelerating relevant crop improvement program.
11. 10
MGI's DNBSEQ™ Sequencing Across Diverse Applications
This year, Prof. Varshney, on behalf of MU, announced the launch of SABC-Advanced
Genomics Platform for Australian horticulture, especially focusing on improving the performance
of five popular horticultural fruit crops, which either lack basic genomic resources or they are not
being used in breeding programs In addition to monetary investment, MGI is supplying the
project with its latest sequencing platforms, namely MGISP-960 High-throughput Automated
Sample Preparation System, DNBSEQ-T7 Ultra-high Throughput Genetic Sequencer* and
ZTRON All-in-one Genetic Data Platform. By adopting MGI’s state-of-the-art DNBSEQ™
technology, large scale sequencing data can be generated in a highly accurate, efficient and
affordable manner by scientists like Prof. Varshney, allowing breeders to later use this
knowledge to produce new and more climate-resilient cultivars.
More recently, Prof. Varshney again joined
hands with MGI to sequence 10,225 chickpeas,
representing the largest effort of its kind for
crops utilizing MGI’s sequencing platform. A
detailed map of variation developed using
sequencing data can help to identify superior
variety for improvement-related traits in
breeding system. Disease and climate
resistance genes are expected to be applied in
a wider range to enhance crop productivity.
Professor Rajeev K Varshney FRS, Murdoch University
100,000
Endemic species sequenced within 10 years
with The African BioGenome Project
10,225
Chickpeas sequenced with MGI’s sequencing
platform
12. Meanwhile in Europe, KeyGene, an international research company focused on developing and
applying technology innovations for crop improvement, became the first in the Netherlands to
acquire, install and adopt MGI’s DNBSEQ-G400 gene sequencer* in plant breeding and plant
research. Based on DNBSEQ™, there is optimism to addressing some of the pain points in the
agrigenomics area. The DNA nanoballs technology is robust and provides highly accurate
sequence data, tackling extreme variation in DNA quality among many diverse crops. Moreover,
it aids in resolving haplotype- based genotyping navigating through complex highly repetitive
heterozygous genomes that often differ in ploidy level, commented by Dick Roelofs, Program
Scientist & Team Leader DNA Innovations at KeyGene. This fast and flexible medium-size
platform uses a unique type of chemistry based on DNA NanoBalls (DNBs) synthesized through
rolling circle which offers innovative possibilities for research projects at KeyGene, including
emerging fields like single-cell genomics.
“With the application of MGI’s sequencing platform, we anticipate being able to sequence more
samples more cost-effectively,” said Dick Roelofs. “In addition, G400’s flexibility provides us with
better control over the turnaround time for data production, while guaranteeing high accuracy
sequence output at low cost and allowing us to develop new sequencing and genotyping
applications for crop improvement in the future.”
From AfricaBP to MU in Australia and KeyGene in the Netherlands, MGI’s high-quality,
accessible and efficient tools are enabling greater efficiency in agricultural breeding, producing
more productive and nutritious crops to feed our burgeoning population. Powered by DNBSEQ™,
MGI’s end-to-end sequencing solutions, including full range of sequencers, automation
platforms, single-cell systems, and bioinformatics products will continue to support scientific
research on crop breeding to improve the global food system.
11
MGI's DNBSEQ™ Sequencing Across Diverse Applications
13. 12
MGI's DNBSEQ™ Sequencing Across Diverse Applications
How do De novo sequencing, QTL
mapping, WGS, and lcWGS
empower breakthroughs in
agrigenomics
AGRIGENOMICS
Sequencing technology is playing an increasingly important role in agriculture, including crops,
livestock and poultry, aquatic organisms, and more. In recent years, scientists have made great
progress in the basic research of animal husbandry and molecular breeding of crops. Based on
high-throughput sequencing, a series of key technologies have emerged to empower genome
map construction, gene mining, and molecular breeding, thereby improving the overall
competitiveness of the agricultural industry.
There are generally several types of sequencing in the agricultural sequencing field:
De novo sequencing
De novo sequencing is a method used to obtain the complete genome sequence information of
the species, including different types of DNA libraries construction, sequencing, assembly and
annotation with bioinformatics methods.
In a recent paper published by iScience titled "The chromosome-level genome for Toxicodendron
vernicifluum provides crucial insights into Anacardiaceae evolution and urushiol biosynthesis",
researchers from Xi'an Botanical Garden of Shaanxi Province in China successfully provided the
first chromosome-level genome for Toxicodendron vernicifluum.
The lacquer tree (Toxicodendron vernicifluum) is an important tree with economic, industrial, and
medicinal values. Despite its considerable significance, genetic information of the species
remains scarce, which has hindered its study and utilization.
Using genomic, transcriptomic, and metabolomic techniques, researchers thoroughly screened
14. 13
MGI's DNBSEQ™ Sequencing Across Diverse Applications
and discovered the candidate genes responsible for urushiol and lignin production in the lacquer
tree. The availability of this genomic data will be helpful in the exploration of urushiol
biosynthesis, as well as molecular breeding and engineering of lacquer trees.
During the research, a total of 130.8 Gb of short reads and 106.28 Gb of ONT long reads were
obtained based on DNBSEQ™ and Oxford Nanopore platforms, respectively. After quality
control and trimming, there were 124.4 Gb of DNBSEQ™ clean reads and 105.28 Gb of ONT
high-quality reads.
In their data, researchers found 79 orthologs containing 33 TvPKS genes involved in urushiol
biosynthesis according to their co-expression profile and homological structure. Based on this,
researchers drew the skeleton of the urushiol biosynthesis pathway and provided more details at
the whole genome level.
DNBSEQ-G400*, the sequencing platform based on DNBSEQ™ technology, helped support the
assembly of the genome, including generating short reads to correct the error for long reads and
producing Hi-C data for chromosome-level assembly and RNA-seq.
QTL mapping
Many agronomic traits of crops, such as quality, yield, and stress resistance, are quantitative
traits. With continuous updates and improvements in molecular markers, mapping populations,
and statistical analysis methods, quantitative traits locus (QTL) mapping has proved an effective
approach for dissecting the genetic mechanisms of complex quantitative traits. In recent years,
increasing numbers of candidate genes within QTL intervals for important agronomic traits of
crops (tomato, rice, and wheat) have been isolated and cloned.
15. 14
MGI's DNBSEQ™ Sequencing Across Diverse Applications
In a research published in G3: Genes, Genomes, Genetics named "Mapping of a major QTL
controlling plant height using a high-density genetic map and QTL-seq methods based on
whole-genome sequencing in Brassica napus", researchers from the Oil Crops Research
Institute in the Chinese Academy of Agricultural Sciences set out to determine the genetic
impact on plant height.
Plant height is a crucial element related to plant architecture that influences the seed yield of
oilseed rape.
Traditional QTL mapping typically constructs segregating populations derived from two parental
inbred lines, which is laborious, time-consuming, and costly. In recent years, a combination of
QTL-seq and traditional QTL mapping has become popular for identifying QTL and involves a
mutual QTL verification process in crops. In a previous study on B. napus, a major QTL
underlying boron uptake was identified by QTL-seq and then molecular markers were developed
based on resequencing data to fine-map the candidate gene.
Therefore, a sequencing platform with high data quality and sequencing throughput is a critical
tool for agricultural genetic breeding. In this research, MGI's DNBSEQ-G400* sequencing
platform was used to analyze QTL and transcriptome sequencing of specific parts of 200
rapeseed F2 isolated populations. In the end, the key QTL locus controlling plant height was
identified on chromosome 10 of the rapeseed.
Whole-genome sequencing (WGS)
Whole-genome sequencing (WGS) is a comprehensive method for analyzing entire genomes. It
is helpful in quickly discovering genetic variation related to important traits of animals and plants
and shortening the experimental cycle of molecular breeding. WGS is now widely used for
sequencing of any species, such as agriculturally important livestock, plants, or disease-related
microbes.
Researchers from the National Academy of Agricultural Science in Korea shared in
"Whole-genome sequences of 37 breeding line Bombyx mori strains and their phenotypes
established since 1960s" the whole-genome sequences of 37 breeding line B. mori strains
established over the past 60 years, along with a description of phenotypic characteristics and
photos. These whole-genome sequences linked to the phenotypic characteristics of the
established breeding line could be valuable resources for the understanding of B. mori genome
and provide more insights into the molecular background of various phenotypes.
The researchers completed library construction and data generation using MGI's
16. genetic architecture of agricultural economic traits in pigs using a low-coverage whole-genome
sequencing strategy", researchers from the China Agricultural University and South China
Agricultural University developed a new, highly accurate, cost- and time-efficient lcWGSmethod
to obtain high-density single-nucleotide polymorphism (SNP) markers for a large Duroc pig
population.
By assessing 21 important agricultural traits in commercial pig herds, they performed
genome-wide association and fine-mapping analyses with high resolution and compared the
results of the inheritance model in depth. Results show that artificial selection plays a significant
role in altering the genetic architecture of agricultural animals, especially for loci that affect
economically important traits. The lcWGS strategy had been proven useful for agricultural
breeding.
The researchers completed Tn5 Library generation and sequencing on DNBSEQ™
technology-based sequencing platforms DNBSEQ-G400*. DNBSEQ™ significantly improves the
accuracy of testing, while its low depth resequencing (Lc-WGS) genotyping is also more accurate
than other methods. MGI's automatic database building scheme significantly shortens the
experimental period and reduces errors commonly found in manual database building, meeting
the aging requirement of molecular breeding.
From developing the economic trait markers of species and other omics research directions, to
protecting the health of crops and livestock, and contributing to global agriculture, MGI provides
end-to-end products for a diverse range of scenarios.
15
MGI's DNBSEQ™ Sequencing Across Diverse Applications
DNBSEQ-G400* sequencing platform and
MGIEasy DNA Library Prep Kit.
Low-coverage whole genome
sequencing (lcWGS)
Low-coverage whole genome sequencing (lcWGS)
has emerged as a powerful and cost-effective
approach for population genomic studies in both
model and non-model species.
According to "Accelerated deciphering of the
18. 17
MGI's DNBSEQ™ Sequencing Across Diverse Applications
MGI breaks down barriers in
population genomics with
comprehensive end-to-end
genomic solutions
POPULATION GENOMICS
With human genetic patterns constantly changing, understanding these dynamic variations helps
unlock more possibilities to tackle diseases and genetic disorders and reinvent molecular
medicine. For decades, many countries have been making progress towards establishing
national genome projects and cohort research, initiating an exciting era for genomics, precision
medicine and precision health overall. A global life science leader and innovator, MGI has been
making these projects possible worldwide with high-quality, simple and fast genetic testing
packages designed for high-throughput requirements.
The discovery of the ABO blood group is often thought to have catapulted the contemporary
study of human genetics in the 20th century. Then, at the start of the 21st century, the Human
Genome Project set up a new chapter in the assessment of our species’ variation. Since then,
the cost of sequencing a whole genome has dropped from $3.8 billion to as low as $300,
opening new opportunities to build repositories of genomic data.
By the start of 2020, there were 187 genomic initiatives globally of which 50% originated in the
U.S. and 19% in Europe. Several countries such as the U.S., U.K., Germany, Japan, and
Australia also have existing population-based sequencing programs underway. However, there
are still blanks awaiting to be filled in underrepresented countries, races and ethnicities. For
instance, while nearly 60% of the global human population is spread across Asia, they have been
grossly underrepresented in the genomes created so far.
Dedicated to facilitating innovative life science technology accessible and beneficial to all, MGI
has been enabling large-scale human genome projects and cohort research in underrepresented
countries by providing a customizable and automated total solution – from library preparation, to
sequencing and bioinformatic analysis. Empowered by its core DNBSEQ™ technology, the
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
ultra-high-throughput DNBSEQ-T20×2 and DNBSEQ-T7 sequencers* have been widely
adopted in mapping national genomic landscape. Since DNBSEQ-T20×2* was launched, MGI
successfully broke barriers by lowering the cost of whole genome sequencing to under $100
when running 50,000 WGS per year, driving the development and expansion of genomics
globally.
Capable of producing up to 50,000 WGS per year, DNBSEQ-T20×2* supports the operation of
six slides simultaneously to produce up to 42Tb per run with PE100 or 72Tb per run with PE150.
Meanwhile, known for its high-efficiency and productivity, DNBSEQ-T7 *can generate 6Tb of
data per day and complete up to 60 whole human genomes per day. Besides their ultra-high
throughput, both platforms have achieved big leaps in overall accuracy, as well as the reduction
of duplicates and index hopping, making them highly suitable for scientific research, clinical
research and disease prevention.
Offering its strong technological expertise in national genome projects in countries such as
Indonesia and Thailand, MGI is empowering life sciences development and future healthcare.
The Indonesian Biomedical & Genome Science Initiative and Genomics Thailand Initiative have
been making headways in establishing their respective comprehensive genome databases by
cataloging thousands of citizens’ genomes. In China, MGI is also playing a key role in The China
Metabolic Analytics Project, a pivotal large-scale genome project that has set out to build a
genomic database with 100,000 deep whole genome sequencing data and 1,000,000
genotyping array data. As of today, the project has achieved breakthrough results and mapped
the first human blood virome of the Chinese population.
Genomics Thailand Initiative
20. The comprehensive workflow starts with the high-throughput MGISP-960 automated workstation
which guarantees high speed and easy operation, improving overall project efficiency and
productivity. After nucleic acid extraction, library construction and high-throughput sequencing,
ZTRON is used for automatic bioinformatics analysis, storage and governance of massive
sequencing data. It can speed up analysis by 60 times with a capacity 2 times larger with its
high-performance edge computing and storage solution, further contributing to the rapid and
easy implementation of large population genome projects.
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
In early 2023, MGI joined hands with Brazilian life science company, Pensabio, to facilitate the
genome sequencing of thousands of patients with rare diseases and hereditary cancers. The
results will serve as foundation for countries to track diseases for early diagnosis and develop
corresponding precision medicine for citizens.
Aside from supporting these far-reaching projects, MGI continues to innovate and upgrade its
products and technologies specific to population genome projects. Under its global “What if?”
campaign first rolled out in Australia, MGI believes sequencing is more than the sequencer.
Integrating sample pretreatment, library preparation, high-throughput sequencing, genetic data
management and more, MGI provides a total package for population genomics. Each
sequencing laboratory can achieve an annual throughput of 50,000 to 1 million WGS, with a fully
automated process from sample to report. Amidst a market that is in urgent need of high-quality
and comprehensive sequencing solutions, MGI’s one-stop sequencing solution for large-scale
population genomics projects will spur further advances in precision medicine and drive
progress towards the goal of making sequencing more affordable and accessible to everyone.
21. Beyond supporting national population genome initiatives, MGI has made considerable efforts
towards the ambitious goal of building the world’s largest database of human microbiome
through The Million Microbiome of Humans Project, which aligns with MGI’s vision to improve
human health through innovative life science. Scientists from China, Sweden, Denmark, France,
and Latvia will rely on MGI's DNBSEQ™ microbial genome sequencing technology to sequence
and analyze one million microbial samples of different populations, aiming to construct a
microbiome map of the human body and laying a solid data foundation for micro-ecological
research. Through the project, MGI continues to contribute to scientific breakthroughs which in
turn benefit mankind and healthcare worldwide.
MGI’s innovative tools have not only redefined the end-to-end, high-throughput “sample to data”
process, but more importantly, turned a new page for many countries and races to develop better
understanding of their origins, revolutions and to eventually improve human health. In addition,
with highly accessible solutions, MGI is lowering the technical and cost-related barriers for coun-
tries eager to kickstart their own human genome projects and furthering the global development
of precision medicine.
20
MGI's DNBSEQ™ Sequencing Across Diverse Applications
The Million Microbiome of Humans Project
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
From Sanger Sequencing to the
Human Genome Project: The
Evolution of DNA Sequencing
Technology
POPULATION GENOMICS
The Human Genome Project was an international scientific research project set out to map,
identify, and sequence all the genes that make up the human genome, as well as improve the
tools for data analysis for the future deciphering of genetic information. The project began in 1990
and was completed in 2003. Since its completion, it has helped to accelerate the field of human
biology, providing us with crucial information about the human blueprint. With such a rapidly
evolving scientific landscape, the field of genomics has seen tremendous breakthroughs, and
new research is utilizing genomics technology to continue to push the boundaries of medical
science. One company that is helping to accelerate these discoveries is MGI, a leading producer
of advanced high-throughput genome sequencing technology.
With the 7th birthday of MGI on April 2023 coinciding with
the 20th anniversary of the Human Genome Project, we look
back at where it all started as well as the importance of
sequencing technology in advancing the field. In this inspiring
interview, we speak to Dr. Radoje Drmanac, co-founder of
Complete Genomics and Chief Scientific Officer at MGI, to
learn more.
Dr. Radoje (Rade) Drmanac is the co-founder and has
served as Chief Scientific Officer since June 2005 at
Complete Genomics and Chief Scientific Officer since 2013
at MGI Tech. He invented and led development of massively
parallel DNA sequencing using DNA nanoarrays,
ligation-based DNA sequencing, and haplotyping by
co-barcoded sequence reads.
Dr. Radoje Drmanac
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
The Human Genome Project (HGP) is celebrating its 20th anniversary this
April. As someone involved in this project from the start, how did this
project come about, and what was your involvement?
The field of genomics was already around before the Human Genome Project started in the
1980s. Many people like George Church, Hans Lehrach and myself were involved in thinking
about how to create chromosome maps or expression sequence tags. Through such thinking, I
became involved in genetic engineering at the Institute for Molecular Genetics and Genetic
Engineering in Serbia. There I started thinking about how to improve DNA sequencing as
sequencing at that time was carried out using the Sanger method. Although I never used this
method myself, I watched my colleagues conduct gel sequencing, and it soon became clear
how slow and difficult it was.
In 1987, I proposed a new method for more efficient sequencing based on DNA arrays called
sequencing by hybridization (SBH). At the same time, the US Department of Energy (DOE),
developer of atomic bombs, was studying the impact of radiation in causing genetic mutations.
They held a meeting to discuss how to find and identify these mutations, and I believe George
Church told them that the best way would be to sequence the whole genome in exposed people.
They initiated a first round of grants to improve technologies for genome analysis, including
sequencing. I applied for this grant from Serbia in 1987, and to everybody’s surprise, including
my own, we received a $150,000 grant to develop that sequencing by hybridization method that
held so much promise for faster, much higher throughput sequencing.
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
In 1988, I proposed massively parallel sequencing (MPS) using microarrays, a radically new
approach, and the proposal was to use emulsion polymerase chain reaction (PCR) on
micro-sized beads to create millions of clonal DNA on such small beads to form these novel
DNA microarrays. Before this, picking and arraying clones was the only viable method.
Then, as a postdoc in 1991, through this connection with the DOE, the whole team – all nine of
us – moved to Argonne National Laboratory near Chicago in the US to continue to develop
sequencing by hybridization technology using the DOE grants.
We also published a couple of papers, the first being in journal Genomics, a paper on genome
sequencing by SBH that was very popular. Then in Argonne National Laboratory, together with
Lee Hood, we published a paper in the journal Science in 1993 that proved in a blind test that
sequencing by hybridization was highly accurate and could be used to sequence DNA using
oligo hybridization.
That is how I first became involved in the Human Genome Project.
How did the Human Genome Project help to propel parallel sequencing
technologies in the life sciences?
I proposed massively parallel sequencing in 1988, and sequencing by synthesis was also
proposed in the 1990s, both long before the genome was sequenced. However, once the
genome was sequenced, these two technologies and our sequencing by ligation became
possible, allowing for routine, affordable individual genome sequencing.
This motivated me to start Complete Genomics in 2005, acquiring funding and starting
operations in 2006. In 2005, we invented DNA nano balls and pattern arrays for massively
parallel sequencing. These clonal arrays were critical to implementing efficient massively parallel
sequencing, and our DNA nano balls were, and still are, the best approach for this. We were the
first to implement pattern arrays, while others used random arrays.
When we started Complete Genomics, within a couple of years of implementation, we achieved
a milestone, an event that promoted the genomic revolution. We sequenced and published in the
journal Science in 2010, for the first time, a whole human genome for $5,000, a 10-fold
improvement, using patterned DNA arrays of DNA nanoballs, a much more efficient,
higher-density sequencing platform.
25. Seven years after the first genome was sequenced for $3 billion, your team
published a $5000 genome, almost 1 million fold cheaper. What was this
journey like, and were there any particular R&D challenges that you had to
overcome?
Many people in the industry, including some of the people we hired, believed that such dense
arrays, were unachievable. Despite this initial resistance, we started making the arrays, and the
first genome was sequenced with, I believe, 600 nanometers center to center, a sub-one-micron
array. We have since continued to push the edge of possibilities. One limitation at the time was
that cameras had fewer pixels than they do today. Today, we have cameras with a hundred
times more pixels and much faster imaging.
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
As the industry was still new, we had to offer it as a service initially. As such, we started this
service for routine genome sequencing for scientists. They would send us their important
samples, and we would sequence them. Nonetheless, there was still a lot of debate regarding
the accuracy of whole genome sequencing by short reads and, despite our efforts, we still had
some errors, so even though it was quite accurate, it was not yet perfect.
There were also questions surrounding whether we could detect a single mutation that causes a
disease. As this had never been carried out before, and as the genome is so big comprising 3
billion chemical letters, there were also uncertainties regarding our ability to identify the single
mutation that causes disease.
26. All things considered, it was really rewarding when, with a long-time friend and colleague, Lee
Hood, we decided to sequence the first family. We sequenced a family of four, two parents and
their two children who were affected with a disease called Miller Syndrome, to prove that we
could identify the cause of Miller Syndrome in the affected children.
We successfully detected the genetic cause of this disease and published our findings that
demonstrated our ability to sequence genomes accurately. These results also highlighted the
importance of sequencing family genomes and their role in discovering genetic diseases. With
that paper and the many others that followed, people soon realized that the genome could be
sequenced efficiently, affordably, and quite accurately, and this is what kickstarted the genome
revolution.
You have had an incredible career, from being the technology developer for
the Human Genome Project to the sub-hundred dollar human genome and
CoolMPS technology. Over the past 20 years, how do you feel the genomics
industry has evolved?
In one sentence, the genomic revolution was made possible by massively parallel sequencing.
Everybody knows that the progress we continue to see would not be possible without this
technology. The cost would not have been able to come down from $5,000 to $1,000 or even to
the very first $100 and sub $100 genome. Over the last 20 years, many applications have been
developed for sequencing because of this ability to carry out efficient sequencing in almost any
lab. Today, almost every aspect of omics uses sequencing.
We measure protein levels in the blood by sequencing barcodes. People measure gene
activities by sequencing. Sequencing became the single assay to measure the molecular state
of our cells. It was not just genome sequencing, but all other omics were enabled by MPS. At the
same time, long single-molecule sequencing was also achieved and made available by multiple
companies.
The revolution then spilled out into knowledge by sequencing all of these samples, having all
these assays, sequencing millions of genomes. We also learned how to barcode single cells,
and now, using dens DNA nanoball arrays, we have the best spatial omics to monitor gene
expression in tissue sections at the subcellular level. All this is enabled by massively parallel
sequencing, and these applications are still growing.
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
27. We have seen in recent years that sequencing is the key to accelerating the
field of omics. What role have both Complete Genomics and MGI played in
this discovery, and what role will they continue to play in its future?
We have always pushed the boundaries, starting with the $5,000 genome, which was so
important. In a way, it proved that routine genome sequencing was possible and that there is
value in individual genome sequencing. After this, we continued to build on initial studies and
develop many different instruments.
Our DNBSEQ-T7* will be remembered as a critical instrument, the first to achieve pair-end
2x150 bases high-throughput genomes in 24 hours. The T7* is an example of the power of
DNBSEQ™ when it is properly implemented with really cool engineering.
We have now also announced DNBSEQ-T20×2* providing a sub-hundred-dollar genome. Our
DNBSEQ™ provides the highest resolution spatial omics due to the high-density arrays. I
believe we will be the first to achieve the $10 genome, as there is no doubt that DNBSEQ™
enables that. We can make four times higher array density than today. The drive for the $10
genome is not just for the inherited genome but because it will allow annual checkups using
deep sequencing in the immune system, cell-free DNA, and in the microbiome, enabling us to
monitor our health and our aging at the molecular level.
26
MGI's DNBSEQ™ Sequencing Across Diverse Applications
28. 27
MGI's DNBSEQ™ Sequencing Across Diverse Applications
One technology that is a less expensive and more efficient technology for sequencing is
CoolMPS, as it allows much longer reads in massively parallel sequencing. We have already
implemented SE400 using standard sequencing technology. With CoolMPS, we are working on
getting to 1,000 bases continuous reads, the SE1000 – continuous MPS for 1,000 bases. This is
so important because it will bring affordable genome sequencing to an even higher level of
completion. There are some types of sequences, like triple repeats, that, when they expand,
cause a disease like fragile X. With these longer reads, we will be able to measure how long
these repeats are, which will tell us if expansion is causing disease or if it is still tolerable.
Combining the efficient sequencing with our single tube LFR technology for haplotype phasing,
solving blind spots by resolving the pseudogenes, separating pseudogenes from the real genes,
and using these longer reads all redefines massively parallel sequencing and brings it to the
level that will enable faster understanding of our genetic program. With this understanding, our
omics tests will be so efficient that we can bring health monitoring omics to all.
We will have such a deep understanding that when we obtain the state-of-the-art measures of
our tissues at the molecular level, we will know what this means and how to prevent disease and
slow aging. We already have a level of understanding that our tissues are primarily aging
because of epigenetics. In a way, epigenetics is controlled by a genome program that uses
methylation and other marks to differentiate cells. In the beginning, there is only one cell, and
then we have hundreds of tissues in the developed organism. Every tissue is locked into its state
DNBSEQ-T20x2* Product Components:
Reagent Module
Stores unreacted reagents
Storage Module
Stores slides and reacted reagents
Optical Imaging Module 1
Captures labeled fluorescent signal
Optical Imaging Module 2
Captures labeled fluorescent signal
Optical Control Module 1
Controls each component of optical imaging
module 1 and transfers fluorescent signal
to CAL file
Optical Control Module 2
Controls each component of optical imaging
module 2 and transfers fluorescent signal to CAL file
BIT Module
Generates FASTQ data or performs
advanced bioinformatics analysis
Power Module
Supplies electricity and compressed
air power
Biochemical Reaction Module
Performs biochemical reactions on slides
6-axis Robotic Arm
Transfers slides between different modules
29. 28
MGI's DNBSEQ™ Sequencing Across Diverse Applications
by these methylation and other marks called epigenetic modifications. These marks are lost or
changed during life, i.e., modified, leading to a loss of young and healthy tissues. We can reverse
this process using transcription factors that promote the re-establishment of young tissue
epigenetic marks. However, it is important that we do not just live longer but that we have longer
healthy and more productive lives.
Everything in biosciences is growing exponentially thanks to these technologies. Our
understanding is exponential, and our technology’s ability to measure things is exponential. We
will definitely have a $10 genome within this decade, and 1,000 base MPS reads, so that, in a
decade or two, after deep understanding of our molecular nature maybe we will be in control of
aging.
With the 20th anniversary of the Human Genome Project and the 7th
birthday of MGI both this April, how do you personally feel about how far
the field of genomics has come? Where do you feel that this sector is
heading?
I am really happy with how things have panned out. If we had not merged with MGI, the field
would be in a totally different place than it is today. Yet, from the beginning, we have always had
this feeling or hope that we could do this almost unlimited level of sequencing. There are so
many genomes and other omics to sequence, and we are unlikely to stop improving even at $10
genome.
The whole field is unstoppable, and we will continue to do wonders, and I am certain that the
true importance of massively paralleled sequencing or any large-scale, efficient sequencing is
still underestimated.
The green energy revolution and electric vehicles are critical. But efficient sequencing, I think,
will be recognized as one of the most important human technologies because it concerns our
health. Our genome touches all aspects of our lives, including genetic needs for personalize
parenting or personalized learning. The whole of medicine will be changed. Imagine having the
ability to deeply, efficiently, and accurately measure your molecular health at an affordable price.
When you combine that enormous data set with artificial intelligence, suddenly, we have
predictions or preventions of disease and aging that are affordable to everybody.
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
Partnering with Gene+ to Provide
Accessible, High-Quality
Oncology Solutions
PRECISION ONCOLOGY
The rise of genomics has changed the face of cancer medicine in terms of prevention, screening,
diagnosis, and treatment. Since 2018, MGI has been working with Beijing GenePlus Technology
Co., Ltd (“Gene+”), a leading supplier for oncology and precision medicine in China, to provide
intelligent and comprehensive high-throughput sequencing technology for solid tumors,
lymphoma, pathogenic microorganisms, early detection of cancer, immunization, and other areas.
32. 31
MGI's DNBSEQ™ Sequencing Across Diverse Applications
Utilizing its core DNBSEQ™ sequencing platforms, MGI empowers the Gene+ all-in-one
high-throughput sequencing solution for customers and users in more than 70 key hospitals and
companies in fields such as oncology and analysis of pathogens. Moreover, MGI is the original
equipment manufacturer of the Gene+Seq-2000 genetic sequencer, which was based on MGI’s
day-to-day, medium throughput benchtop sequencer DNBSEQ-G400* and has been certified by
the Chinese National Medical Products Administration (NMPA).
The key to precision oncology is developing targeted therapy by exploring different biomarkers of
tumors and finding their origin. However, this is never easy given the inherent complexity and
heterogeneity of cancer, as well as its risks of genetic mutation. To this end, supported by MGI’s
DNBSEQ™ technology, Gene+ has been contributing to clinical trials and research to help
clinicians determine the safest and most effective cancer treatment by combining clinical
features and individualized tumor genetic profile. Based on this powerful technology, Gene+ has
furnished a complete tumor detection product matrix with great clinical application results.
Specifically, MGI’s DNBSEQ™ technology’s significant advantages of low duplication rate and
high data utilization rate make it especially valuable for high-depth sequencing and analysis of
low-concentration oncology samples or those of high complexity, such as peripheral blood and
circulating tumor DNA. DNBSEQ-G400*, with a detection limit between 0.1-0.2%, has enabled
the Gene+ lung cancer MRD product, OncoMRD Lung, to achieve a low-frequency mutation
detection rate of 0.02%, which plays a critical role in improving the overall product performance
and thereby diagnostic accuracy. Backed by these significant advantages, DNBSEQ™ enabled
the first study, published on Cancer Discovery, to ever define the potentially cured population in
localized non-small cell lung cancer by way of longitudinal undetectable MRD.
Statistical data as of 2023.06
Together with MGI, Gene+ has achieved:
GenePlus achievement
Beijing GenePlus Technology CO., Ltd., with genetic technology as its core, focuses
on the exploration of precision oncology and is committed to becoming the most
trusted cancer prevention and treatment service platform.
Samples tested
550,000+
SCI publications
300+
Research projects
cooperation
700+
if Accumulated
impact factors
3,000+
Key hospitals
cooperation
900+
Pharmaceutical
partners
70+
33. As early as in 2018, MGI and Gene+ announced the 100T project aimed at evaluating the
performance of domestic sequencers, bringing the Gene+Seq-200/2000 sequencing platform
and relevant tumor high-throughput sequencing solutions into clinical application and public
awareness. It laid the foundation for accelerating the application and accessibility of domestic
sequencing instruments, as well as generating new clinical research results and evidence to
help improve cancer survival. In 2022 alone, Gene+ published more than 75 articles and
achieved remarkable results in large-scale clinical studies such as TRACELib002, TNBC, and
CTONG2201.
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
Equipped with the versatile and flexible DNBSEQ-G400*, the Gene+ all-in-one solution enables
clinicians and researchers to conduct clinical diagnosis and research, which have accurately and
effectively informed precision cancer medicine in terms of selecting the optimal treatment for a
patient based on the specific genetic makeup of their tumor.
In addition to facilitating high-quality, high-efficiency cancer sequencing, the partnership between
MGI and Gene+ is rooted in a shared vision for promoting the growth of precision oncology and
making it more accessible to all. Augmented by a strong interdisciplinary collaboration among
experts and stakeholders with medical, clinical, biological, translational, and technical expertise,
MGI and Gene+ maintain ongoing technical communications on reagent optimization, product
design, and technological update to improve the performance and accuracy of applied products.
Gene+, Beijing
34. While cancer precision medicine is gaining momentum, many advances in the field have yet to
reach the masses due to high costs and insufficient clinical trial design and data. The
competitive pricing and low running cost of DNBSEQ-G400* have significantly increased the
cost-effectiveness of cancer sequencing with Gene+, removing another barrier in making it part
of routine medical care, while making precision oncology ever more of an accessible option for
patients and medical personnel.
To date, the Gene+ all-in-one high-throughput sequencing solution, as empowered by MGI’s
high-quality, high-accuracy, and cost-effective sequencing technology, has benefited over
300,000 patients in need of accurate tumor diagnosis and treatment. Besides informing
treatment, it can also identify mechanisms of drug resistance and relapse, which has helped to
slow the progression of the disease. Precision oncology brings with it a full cycle of management
characterized by treatment that is directed to the root cause of the disease. Instead of longer
treatment with a high risk of failure, targeted therapy is improving cancer patients’ chances of
recovery, allowing them to get back on their feet far more quickly, with significantly fewer
negative side effects, and at a much lower cost.
Looking ahead, MGI and Gene+ have plans to collaborate on more of MGI’s innovative
sequencers, including DNBSEQ-G99* which features ultra-fast applications, DNBSEQ-E25*
which boasts portability, and DNBSEQ-T7* with ultra-high throughput. Furthermore, they will
work closely on multi-dimensional development projects such as laboratory automation,
methylation technology development, and single-cell product application promotion to further
advance clinical and scientific research in precision oncology.
33
MGI's DNBSEQ™ Sequencing Across Diverse Applications
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
MGI’s DNBSEQ-T7* facilitates
ultra-deep sequencing of
high-complexity metagenomic
samples
METAGENOMIC RESEARCH
Thanks to high-throughput sequencing
technologies, shotgun metagenomic methods
were made possible and had effectively
transformed microbiology. Today, advances in
both short- and long-read technologies are
overcoming many of the previous challenges
affecting metagenomic profiling, especially of
highly complex samples and environment.
Researchers from France's National Research
Institute for Agriculture, Food, and Environment
(INRAE) examined the performance of seven
PEER-REVIEWED PUBLICATION - SCIENTIFIC DATA
Overall comparison between observed and excepted
mock compositions for each platform.
Credit: Victoria Meslier, Benoit Quinquis, Etc.
short- and long-read sequencing platforms in analyzing high-complexity metagenomic samples.
The study, published in the Nature Portfolio journal Scientific Data, ran mock samples between
2018 and 2019 on various mainstream sequencers at the time, including MGI's DNBSEQ-T7* and
DNBSEQ-G400*.
Within this wide range of sequencing technologies tested, DNBSEQ-T7* was recognized for its
ultra-high throughput and excellent accuracy. “We were surprised by the T7’s performance*,” said
senior author Mathieu Almeida, a research fellow at INRAE. “It provides ultra-deep sequencing in
a single run with similar low error rate compared to the other platforms, making it at the time of our
study one of the most affordable technologies for metagenomic sequencing.”
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MGI's DNBSEQ™ Sequencing Across Diverse Applications
In the study, three uneven synthetic microbial communities were constructed, consisting of up to
87 genomic microbial strains DNAs each and spanning 29 bacterial and archaeal phyla. They
represented some of the most complex and diverse communities used for sequencing
technology comparisons. The mock1 (71 strains) was sequenced using all platforms, mock2 (64
strains) was additionally sequenced to estimate the impact of various microbial richness, while
MGI’s platforms were not performed on mock3.
To assess the impact of sequencing depth, the team ran a subsampling analysis and compared
observed and theoretical genome abundances across samples at multiple depth from 10,000 to
1 million reads. Overall, Spearman rank correlations for all platforms were high at above 0.9
when mapping at least 100,000 reads. Among them, the correlations of T7* and G400* were the
best in mock1 and remained excellent in mock2.
In addition, differential analysis between observed and excepted species abundances was
performed in mock1. Results showed that over or under abundance estimation for most
genomes had little to do with the sequencing platform, read length, taxonomy, GC-content,
genome size and genome completeness, even at a low depth of 500,000 reads. In fact, most
genomes were accurately estimated on all sequencers, with the observed normalized
abundances generated by T7* charting very close to the excepted values.
Based on performance analyses of the different sequencers, the study formed a microbial
metagenomic sequencing benchmarking database, providing researchers and scientists a
comprehensive and authentic reference for sequencing platform selection. In particular, the
findings demonstrated the promising value of MGI’s DNBSEQ-T7* in metagenomic sequencing.
Boasting high stability and accuracy as shown in the data, combined with outstanding
throughput, T7* makes a strong platform for the identification of species and functional genes in
highly complex microbial communities. Its upgraded biochemical, fluidics, and optical systems
are not only making sequencing more efficient and productive, but also continuing to support
research into the structure and diversity of microbial communities.
37. 36
MGI's DNBSEQ™ Sequencing Across Diverse Applications
MGI demonstrates comprehensive
initiatives in infectious disease
monitoring and control
PANDEMIC RESPONSE
Recent progresses in genomics and bioinformatics have shone a light on their importance as
public health tools against infectious disease threats like COVID-19, influenza, monkeypox, and
tuberculosis. Powered by cutting-edge high-throughput sequencing and lab automation
technologies, MGI has been actively facilitating rapid and accurate analysis of pathogenic DNA
for the detection of new threats and epidemic outbreaks, fueling more effective interventions to
monitor and prevent the spread of diseases.
High-throughput sequencing can accurately identify pathogens and provide in-depth information,
such as traceability analysis of pathogenic microorganisms, drug resistance genes, and virulence
factor analysis. It is gradually becoming one of the most important technical means for the
prevention and control of infectious diseases. Virus genome sequencing, enabled by MGI’s
various types of high-throughput genetic sequencers*, has notably assisted in painting a fuller
and better picture of SARS-CoV-2 through COVID-19 diagnosis, study on its epidemiology and
virology, and the tracing of geographical origin and source transmission chain of different strains.
38. 37
MGI's DNBSEQ™ Sequencing Across Diverse Applications
In fact, it was gene sequencing that allowed researchers and healthcare professionals to first
monitor the spread of the Omicron variant, one of the dominant strains of the virus circulating the
world.
MGI's high-efficiency and innovative instruments were utilized in the detection and tracing of the
Omicron variant to safeguard local communities in more than 70 countries to date, including
South Africa, Serbia, Saudi Arabia, United Arab Emirates, Canada, Australia, and China. Its
proprietary ATOPlex technology, an affordable and fast two-step multiplex PCR method,
contributed to the discovery of the first case of the Omicron variant in Sweden and Saudi Arabia.
Equipped with its multiplex PCR technology, the core platform provided effective whole-genome
sequencing and monitoring of the new variant. It also enabled continuous mutation detection
and analysis for enhanced detection performance, further contributing to global pandemic
control efforts.
Using ATOPlex, MGI has empowered numerous water monitoring initiatives worldwide to
contribute to water quality and food safety improvement. In fact, ATOPlex, along with MGI’s
DNBSEQ-G50* genetic sequencer and MGISP-100 automated system, were credited for helping
scientists from the South African Medical Research Council (SAMRC) in first detecting
fragments of the Omicron variant in wastewater samples collected across Cape Town, which
informed a timely public health response amidst a surge in local cases during that time.
Recently, MGI announced support for a graduate research project at Australia’s University of
Queensland on wastewater monitoring of antimicrobial resistance in the water environment with
ATOPlex. The company also added to its portfolio environmental DNA (eDNA) sequencing
products to help detect any potential disease outbreaks in water sources.
Besides SARS-CoV-2, whole genome sequencing and metagenomic sequencing have played
an important role in the identification, molecular typing, drug resistance monitoring, and
ATOPlex Library
Preparation
High-Throughput
Sequencing
Data
Processing
Sample
Treating
Workflow
Fast and Comprehensive
0.5 hour 4-6 hours 10-48 hours 1-2 hours
39. Notably, the discovery of the first imported case of monkeypox in Chongqing, China was
facilitated by the ultra-high-speed DNBSEQ-G99* within 11.5 to 16 hours from sample library
preparation, to sequencing and bioinformatic analysis of the virus. In addition, v technology* was
used in metagenomic sequencing to successfully identify the main pathogen from the body fluid
samples of a patient with severe psittacosis.
38
MGI's DNBSEQ™ Sequencing Across Diverse Applications
traceability analysis of other disease agents. To address the continuous need for rapid
identification and traceability of new unknown pathogens, MGI provides a high-throughput
sequencing platform* integrated with a pathogen detection system, covering the whole process
from sample to report output. The system is compatible with DNBSEQ-G99*, DNBSEQ-E25*,
DNBSEQ-G400* and DNBSEQ-G50* genetic sequencers, with supporting hardware and
compatible reagent kits to enable an extensive range of pathogen testing.
MGI's DNBSEQ™ platform has accumulated a strong, practical foundation in the detection and
research of pathogenic microorganisms. At present, it is assisting scientific research units in
universities and local disease control institutions in the discovery, genome sequencing and
traceability of various pathogenic microorganisms, including Mycobacterium tuberculosis,
Chlamydia psittaci, the monkeypox virus, SARS-CoV-2, and influenza viruses. This has in turn
enabled early detection of outbreaks, etiological monitoring and early warning, and risk
assessment.
First Imported Case of Monkeypox, Chongqing, China.
40. 39
MGI's DNBSEQ™ Sequencing Across Diverse Applications
The proprietary technology also enabled assembly of the pathogen genome, demonstrating
strong data validity, great sequencing coverage and depth, as well as higher detection sensitivity.
With a commitment to building core tools and technology to lead life science through intelligent
innovation, MGI will continue to empower researchers and healthcare professionals with its full
suite of genetic sequencers*, laboratory automation, laboratory management systems and more
in monitoring infectious disease threats and providing insights into how and where infections are
being passed on to inform public health and policy and mitigate the next pandemic.
mNGS
solution
Single/mixed infection pathogen identification
Pathogen genome assembly
Drug resistant and virulent gene prediction
tNGS
solution
Pathogen genome assembly
Variant surveillance
Genotyping and tracing
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41. 40
MGI's DNBSEQ™ Sequencing Across Diverse Applications
Enhancing medical access in rural
areas with pioneering remote
robotic ultrasound technology
CUTTING-EDGE MEDICAL PLATFORM
Today, up to 3.5 billion people – almost half of world’s population – lack access to essential health
services. Countries are facing insurmountable healthcare challenges, from an increase in patients
with multiple chronic diseases amidst an ageing population to massive shortages in doctors and
nurses. In rural communities, in particular, infrastructure limitations such as no or poor power
supply, hard to reach locations and security issues pose as further hindrances, leading to a
greater divide in healthcare access and outcomes in some groups.
Guided by a vision of enabling affordable and effective healthcare for all, MGI, widely known as a
leading provider of innovative high-throughput genetic sequencing solutions, has expanded its
RD expertise and know-how to develop new and innovative healthcare tools that are also
cost-effective. Leveraging the digital transformation of healthcare that is rooted in the power of
new technologies, 4.5G/5G, data, AI and more, MGI introduced its cutting-edge medical platform
MGIUS-R3, the first remote robotic ultrasound system in China that can achieve “remote
real-time diagnosis”.
42. 41
MGI's DNBSEQ™ Sequencing Across Diverse Applications
Combining robotic technology, remote real-time control system and high-resolution ultrasound
imaging, MGIUS-R3 overcomes the distance limitations of traditional ultrasound diagnosis
and treatment methods without the need for a physician to be at the same location as the
patient. The device holds great promise for improving health outcomes, lowering the cost of
care, promoting access to high-quality precision medical services, and improving the human
care experience for all.
“Everyone has the right to access healthcare, and the adoption of digital healthcare tools and
services is a vital step towards upgrading the quality and consistency of healthcare services
worldwide,” said Dr. Jiang Hui, Chief Operating Officer of MGI. “MGIUS-R3 solves the problem
of shortage of ultrasound doctors in remote and rural settings and reduces heavy workload for
current doctors. It eliminates geographical limitations and improves healthcare system efficiency
by enabling remote patients to access advanced healthcare resources and get diagnosed
immediately.”
R3 integrates tele-robotic ultrasound technology and 4.5G/5G networks to provide signal and
data connections for remote ultrasound robots to help doctors control patient-end ultrasound
probes for diagnosis, while maintaining the high levels of synchronization required between
surgeons’ hand movements, image transmission and force feedback. It is equipped with multiple
sensitive ultrasound probes on its robotic arm, which can be operated by a doctor through a
control system. Its flexible manipulator system can also simulate manual operation throughout
the process to perfectly reproduce expert techniques.
Application Scenarios
Frontier aid
Ships
GP
Rural hospitals
International
consultations
Community
health centers
Ambulances
Telemedicine
Remote ultrasound
consultation center
ICU
Physical
examination
Emergency
department
Anesthesia
43. Standing at the forefront of digital health, MGI aims to even out the distribution of medical
resources and makes ultrasound diagnosis more accessible.
In China, Shenzhen’s Luohu Hospital Group began trialing MGIUS-R3 in as early as 2017.
During the pandemic, when there was an extreme shortage of doctors and nurses, the device
was deployed in local fever clinics, isolation wards and mobile hospitals. At Shenzhen Luohu
People's Hospital, MGIUS-R3 was responsible for providing medical testing and ultrasonic
diagnosis for nearly 2,000 patients. It not only helped to save lives and ease the shortages in
medical resources, but also reduced the risk of transmission of COVID-19 to medical staff.
On International Women's Day in 2022, MGIUS-R3, the world’s first tele-robotic ultrasound
system that can detect cancer remotely, played a pivotal role in providing a three-day voluntary
early breast cancer detection and diagnosis service for nearly 100 female employees at Roche
in Shanghai. More recently, MGI entered an exciting partnership with Siemens Healthineers to
adopt MGIUS-R3 for liver disease detection for patients in rural areas.
Outside of China, MGI helped establish remote ultrasound diagnosis services and training for
the primary care center in Vall d’ Herbon Barcelona Hospital with the advanced MGIUS-R3.
Despite being over 10,000 kilometers away, a physician from Shenzhen Luohu People's Hospital
in China was able to finish a sample scanning of obstetric ultrasound remotely by utilizing
MGIUS-R3 for a patient in Vall d’Hebron in Spain. The installment of the device is expected to
address the prevalent shortage of doctors in Spain, while facilitating more frequent exchanges of
experience and knowledge among doctors and research experts for the benefit of local patients
and the healthcare system.
In addition, MGI supported the Department of Internal Medicine at the University of Pisa in Italy
to provide remote consultation in community clinics in Pisa, as well as regular consultation
42
MGI's DNBSEQ™ Sequencing Across Diverse Applications
After detection, the scan results can be transmitted to the
patient through real-time network, while the doctor can
conduct real-time communication with the patient through
an interactive screen during the whole screening process.
Blending robotics, teleoperation and ultrasound imaging
technology, MGIUS-R3 is widely used in diverse fields,
including healthcare aid in rural areas or island, internal
hospital telemedicine, massive body check, breast cancer
screening, interventional surgical assistance and more.
44. services from experts in university hospitals. The application of MGIUS-R3 include Abdomen,
Vascular, Small Part, Urology, Gynecology and MSK, with flexible ultrasound image parameters
that can be adjusted without any latency, supporting rapid, real-time diagnosis. “Robotic
Ultrasound System has consistently demonstrated excellent B-Mode image quality, indicating
that the ultrasound equipment itself is of very good quality,” said Dr. Mario Meola, Associate
Professor of Clinical Nephrology at the University of Pisa.
Over the years, the innovative MGIUS-R3 has garnered numerous honors and awards, notably
iF Design Award for its innovative function and exquisite design, as well as first prize in the
Blooming Cup 5G Application Competition, Outstanding Product Award in Global 5G Application
Competition, and first prize in the China Medical Device Innovation and Entrepreneurship
Competition. The device is now in use in over 32 provinces and regions in China, in addition to
Latvia, Italy and Spain, proudly contributing to the improvement of local medical ultrasound
services and relieving tension in medical resources.
From genomics platforms to automation tools and novel products, MGI never ceases to lower the
barriers to access cutting-edge yet affordable technologies. With growing clinical applications
worldwide, MGIUS-R3 has the potential to address many of the obstacles brought forth by a
fragmented and uneven healthcare system, making sure that no one is left behind.
Dr. Andrew Antolana, Radiologist, Vall d’Hebron
43
MGI's DNBSEQ™ Sequencing Across Diverse Applications
*Products are provided for Research Use Only. Not for use in diagnostic procedures (except as specifically noted)
45. 5999*2011*2754
4495kg
230*57*42
180g
50*32*160
46
MGI's DNBSEQ™ Sequencing Across Diverse Applications
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46. To Develop and Promote
Advanced Life Science Tools
for Future Healthcare
Leading Life Science
Innovation
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