KeenMind is a clinically proven extract of Bacopa monnieri that promotes memory, recall, concentration, and mental clarity in adults and children. It is the result of 30 years of research by the Central Drug Research Institute in India. Double-blind studies in Australia found that after 12 weeks, KeenMind significantly improved speed of learning, memory consolidation, and mental processing with no side effects. It contains optimum levels of bacosides and other constituents that have cognitive benefits and is the only Bacopa product to meet these standards.
Zangara nutraceutical business & technology nov dec 2008Andrea Zangara
The document discusses various herbs, nutrients, and compounds that may support brain health and cognitive function. It provides an overview of evidence for antioxidants like vitamins, minerals, omega-3 fatty acids, choline, citicoline, phosphatidylserine, and acetyl-l-carnitine in supporting cognition and reducing age-related decline. It then focuses on specific evidence for a patented extract of Bacopa monniera (KeenMind) in improving memory and cognitive processing based on three randomized controlled trials. The author concludes that KeenMind shows potential as a natural cognitive enhancer but that more research is still needed.
Intellectual performance is achieved in 3 steps. Grasping, Storing and Recall. This presentation shows the scientific way to improve overall intellectual performance. It has 3 products respectively for Grasping, Storing and Recall. For products, write to ayursecret@gmail.com
THE ENDOCANNABINOID SYSTEM - Cady Wellness InstituteLouis Cady, MD
This lecture, presented on February 2, 2018 at the Cady Wellness Institute in Newburgh, IN, represented Dr. Cady's review of the current peer-reviewed medical literature current as of that morning. The concepts of "endocannabinoids" vs. "phytocannabinoids" were reviewed. Themes in the medical literature were explored, including the relationship of the endocannabinoid system and CB! and CB2 receptors to modulate hippocampal neurogenesis, cause apoptosis in breast cancer cells, and many other interesting correlations. A careful review of legal vs illegal options for obtaining plant phytocannabinoids in the state of Indiana was emphasized.
This document summarizes research on the anti-aging benefits of astaxanthin. It discusses several human clinical studies that have shown astaxanthin to have benefits for eye health including reducing eye fatigue, strain, and improving accommodation at doses of 4-12mg per day. Studies also found improved visual acuity, depth perception, and retinal blood flow. The document suggests astaxanthin addresses many aging-related health concerns and that most people over age 40 should supplement with at least 4mg daily to protect cells, DNA, mitochondria, and reduce inflammation.
This document provides an overview of memory enhancers from nutraceuticals. It discusses what nutraceuticals are and how they can benefit memory through functional foods and herbal extracts. Several herbal extracts are described that may help enhance memory, including Bacopa Monniera, Ginkgo Biloba, Centella Asiatica, and others. The document outlines how these herbal extracts may improve memory through antioxidant effects and inhibition of acetylcholinesterase activity in the brain.
Cognitive Benefits of Exercise for Children and TeensMark Dreher PhD
The brain evolves during our childhood years as it continues to develop and is affected by lifestyle habits such as physical activity, cognitive activity, nutrition and sleep.
Although there is growing scientific evidence that exercise is associated with improved cognitive function, academic performance, and overall health in children, the limited amount of time generally dedicated to physical activity during the school day continues to decline in many schools.
The activity requirements for healthy brain and cognitive function are really relatively modest. For children, moderate aerobic activity of about 60 minutes a day can make a big difference, especially in children that are currently low-performers. There is work to be done in the United States and other countries to meet these activity goals as only about 30% of high school students achieve them.
This presentation provides a current summary of the human research on aerobic exercise and cognitive function in children and teens.
Mark Dreher PhD
Abstract
Curcuminoids is the mixture of curcumin, demethoxycurcumin and bisdemethoxycurcumin obtained from dried
rhizomes of Curcuma longa, commonly used for its wide therapeutic value. However, the absorption efficacy of
curcuminoids is too low to exhibit its proper therapeutic value. Thus, a new preparation named as
BioTurmin-WD (water dispersible curcuminoids) was developed for improved bioavailability. By using human
Caco-2 cell monolayer, the permeability efficacy of BioTurmin-WD was evaluated and compared with that of
95% pure curcuminoids. Caco-2 model predicts the in vivo absorption of drugs across the gut wall by measuring
the rate of transport of a compound across the Caco-2 cell line. BioTurmin-WD was added to the apical layer and
basolateral samples were collected over 120 min to examine the concentration diffusing across the cell
monolayer. Permeable curcuminoids across the cell monolayer was analysed through reverse phase high pressure
liquid chromatography (RP-HPLC). Apparent permeabilities (Papp) of BioTurmin-WD and 95% curcuminoids
were found to be 5.89 × 10 -6 and 2.65 × 10 -6 cm/s respectively. The apparent permeability coefficient of
BioTurmin-WD was 7.03-fold higher than 95% pure curcuminoids. Percentage permeability of BioTurmin-WD
(0.2945) was much higher than 95% curcuminoids (0.0859). Results indicated that BioTurmin-WD have a much
higher absorption capacity (bioavailability) compared to 95% pure curcuminoids. Thus, BioTurmin-WD may be
useful as a dietary supplement with greater bioavailability to exert clinical benefits in humans at a lower dosage.
Keywords: BioTurmin-WD, bioavailability, Caco-2 cells, Curcuma longa, curcuminoids, permeability
This document provides an overview of brain health and neurogenesis. It discusses how neurogenesis occurs in two regions of the adult brain, and its significance for functions like memory, learning, and mood regulation. Conditions and substances that can decrease neurogenesis are outlined, as are nootropics, foods, and behaviors that can enhance it. The document also examines neurotrophic factors that stimulate neurogenesis, like nerve growth factor and brain-derived neurotrophic factor. Finally, it discusses nerve growth factor receptors and their importance for maintaining proper neurogenesis.
Pacitane nanoparticles drug release for brain disorderIJSRED
This document summarizes research on using nanoparticles to deliver drugs to the brain and treat brain disorders. It discusses how nanoparticles carrying drugs can be administered orally and pass through the gastrointestinal tract and bloodstream to reach the brain. Specifically, it describes an experiment where pacitane nanoparticles were prepared and tested as a potential delivery system for treating brain disorders like Parkinson's disease and schizophrenia. The nanoparticles were characterized and tested for drug release in vitro. The results showed 80% of the drug was released within 24 hours. The conclusion is that nanoparticle drug delivery could provide an effective therapy for brain disorders.
Introduction to cognitive enhancers (nootropics) and their role in brain aging. The presentation limits itself in over-the-counter 'nootropics' and aims at providing the tools to safely approach these supplements.
The document discusses how proper nutrition is essential for brain development and function. It notes that the fetal brain develops rapidly from weeks 10 to 18 of pregnancy, making nutrition critical. Deficiencies can lead to growth and developmental issues. Later, certain vitamins and minerals like B12 and iron are needed to prevent impaired cognitive function. The document also examines how different foods contain precursors for neurotransmitters like serotonin, dopamine, and norepinephrine that allow the brain to function properly. Adequate glucose, protein, vitamins, and minerals from foods are required to meet the brain's needs.
This study aimed to investigate the effects of caffeine abstinence and reintroduction on cognitive domains like attention, memory, and executive function. Six adult male volunteers who had been abstinent from caffeine for 6-10 months participated. During the abstinence phase, participants showed reduced sustained attention and increased response times on executive function tasks compared to when regularly consuming caffeine. Upon caffeine reintroduction, participants demonstrated improved accuracy and speed on an executive function task, but memory was unaffected by abstinence or reintroduction. The preliminary results suggest that caffeine abstinence can impact attention and executive function.
Memory booster herb (natural cognitive enhancers): An overview Neeleshkumar Maurya
Abstract The main important aspect to differentiate from one individual to other human beings is Memory as it is important to recognize individual self. There are three basic forms of memory which allow the brain to encode, store, and retrieve. Without these basic forms of memory, individual even fails to build personal rapport, to acquire new knowledge, and unable to do basic functions of daily life. From last decades, Indian and Chinese cultures took interest for natural remedies by developing various traditional medicines from herbs for the declining activity of cognition, reverse memory loss and to increase learning power. Neotropic herbs are famous for brain acting herbs and smart drugs called from its isolated constituents as it helps to enhance circulation of blood in the brain. This Review focuses on natural agents and Herbs which act as memory boosters.
Keywords: Memory, herbs, Cognitive, enhancers, Memory enhancing herbs, improving memory, Brain booster
1. Bacopa monniera, commonly known as Brahmi, is an herbaceous plant used in Ayurvedic medicine as a brain and nervous system tonic.
2. It contains saponins and alkaloids such as bacosides A and B which are thought to improve cognition, memory, and motor function by supporting nerve cell transmission in the brain.
3. Brahmi has a wide range of traditional uses for conditions like epilepsy, inflammation, and mental health issues and modern research supports effects such as antioxidant, anti-stress, and cognitive enhancing properties.
This document discusses bioinformatics tools and databases that can be used in the drug design process. It describes how target identification is an important first step, and involves using databases like SwissProt, NCBI BLAST, and PDB to find protein sequences related to a disease. Computational tools like SPDBV, Autodock, Modeller are then used to model protein structures and design drug molecules that can bind to targets. The workflow involves refining drug candidates using techniques like QSAR before experimental testing.
Efficacy and safety of human placental extract solution on fatigue (http://pl...Swapan Das
From:http://placentrex.blogspot.com/
For the readers of Human Placental Extract (HPE) Blog blog we have come up with the following study recently conducted by a Korean team on the efficacy and safety of Human Placental Extract solution on fatigue. Fatigue is a common symptom, but only a few effective treatments are available. This study was supported by a grant from Unimed Pharm., INC. and was conducted at the requests of the Korea Food and Drug Administration (KFDA).
http://placentrex.blogspot.com/2011/09/kfda-requests-for-study-of-hpes-role-on.html
The document discusses various topics related to the mind, including gratitude, mindfulness, neuroplasticity, epigenetics, the unconscious mind, mental practice, visualization, and the placebo effect. It provides examples of research showing how mental practices like meditation can positively impact the brain and biological systems, and discusses how experiences shape the structure of the brain through chemical changes and the wiring of neurons.
Check out what Washington State University said about ProtandimDes Mc Dermott
"Protandim is possibly the most Extraordinary Breakthrough in the history of medicine". Protandim Nrf2 & NRF1 Synergizers effectively to reduce oxidative stress by 40% in just 30 days and also supports mitochondria production to fight the effects of aging.
Hemp Oil: What Can It Do For You? Lebanon, TN 04 06 2018Louis Cady, MD
In this presentation, Dr. Cady reviews the peer-reviewed medical literature for the endocannibinoid system, the concept of endocannibinoid deficiency syndrome (now well established), and citations dealing with the multiplicity of health conditions for which a full spectrum hemp oil should be considered as a reasonable supportive strategy. The difference between the generic "CBD Oil" that is available at health food stores compared to the Zilis products is touched on. The Zilis products appear to have better absorbability, faster onset of action, and scientific studies elucidating the true duration of action of CBD levels in blood serum.
This presentation was given to a very appreciative audience at the Friendship Church in Lebanon, TN (a suburb of Nashville).
KeenMind is a Bacopa monnieri product independently assessed as the best clinically proven natural medicine. It is the result of 30 years of research by India's Central Drug Research Institute to promote memory, recall, concentration, and mental clarity in adults and children, as proven in Australian studies. KeenMind contains a unique broad-spectrum Bacopa extract with optimum levels of 55% bacosides.
This document discusses the "Seed to Patient" concept for developing standardized herbal medicines. It provides case studies of Remotiv and Gincosan, herbal products for depression/anxiety and cognitive function, respectively. The summary discusses how controlling all stages of production, from seed/plant source to clinical trials, allows for reproducible results and reliable, clinically proven herbal medicines.
The document discusses regulations for traditional Chinese medicine products and supplements in Singapore. It notes that imports of these products have increased significantly in recent years. The Health Sciences Authority regulates health products in Singapore, including Chinese proprietary medicines and health supplements. For Chinese proprietary medicines, companies must list and get approval for individual products. Health supplements do not require pre-market approval but companies should comply with Health Sciences Authority guidelines.
1. NUtrials is a recently established service at Northumbria University that provides testing and product development support for the food, functional food, and nutraceutical industries.
2. Northumbria University has expertise in food analysis, regulation of metabolic processes, physical and cognitive performance, and defense against oxidative stress through three research centers.
3. NUtrials aims to offer a single interface for industry, reduce costs through consolidated marketing and PR, and help move products from concept to market through its range of expertise and services.
This document provides information on various herbal highs and psychoactive substances, including their history, effects, risks, and legal status. It discusses substances like cocaine, amphetamines, LSD, MDMA, ketamine, magic mushrooms, cannabis, and new synthetic drugs sold as legal alternatives. The document notes that while some natural substances like cannabis have a long history of traditional use, new synthetic drugs and extremely potent strains lack research on long term safety. It also discusses issues around legal regulation and harm reduction approaches for psychoactive substances.
This document summarizes a study that aimed to understand the use of smart and eco drugs (SD/EDs) among customers at Dutch smartshops. The study found that most customers used SD/EDs like energy drinks and magic mushrooms to enhance their mood. Customers reported getting information from other people and shops about SD/EDs and felt knowledgeable about safe use. The study concludes that smartshops provide an informative environment for SD/ED use and their model could inform how other countries distribute drug information.
This document summarizes a study that tested the effectiveness of ZT-1, a precursor of the alkaloid huperzine A, and donepezil in reversing cognitive impairment induced by scopolamine in elderly volunteers. ZT-1 and donepezil were both able to significantly reduce impairments in attention, working memory, and episodic secondary memory caused by scopolamine administration. ZT-1 showed effects comparable to donepezil and indicated potential for further clinical research of huperzine A and related compounds in treating cognitive deficits. The study demonstrated the sensitivity of the CDR cognitive assessment system for detecting effects in the scopolamine model of cognitive impairment.
1. www.flordis.com.au PO Box 1027, Crows Nest NSW 1585, Australia Tel + 61 2 9431 7200clinically proven natural medicines
KeenMind®
The world’s leading researched
Bacopa monnieri
Promote memory and recall,
concentration and mental clarity in
adults & children
4
3,5
* maximal effects evident after 12 weeks treatment in subjects aged 18 to 60 years
** ability to hold and use information “online” after 90 days treatment in subjects
aged 40 to 65 years
References
1. Singh, R.H . & Sing, L., Res. Ayur. Siddha 1980, 1:133-148.
2. Sharma et al, J. Res.Educ. Indian Med. 1987 1:12.
3. Stough et al, Psychopharmacology (Berl.). 2001, 156(4): 481-484.
4. Roodenrys et al 2002. Neuropsychopharmacology 27 (2):279-281
5. Stough et al, Phytotherapy Res. 2008 DOI: 10.1002/ptr.2537
Cognitive function P value
Improved ‘working memory’** <0.035
Improved speed of learning* <0.042
Improved memory consolidation* <0.042
Improved speed of visual <0.018
information processing*
Improved speed of early <0.05
information processing*
Decreased forgetting rate* <0.03
(CDRI 08)
1,2,3,4,5
Mechanism of Action
Evidence suggests modulation of the
cholinergic system and/or antioxidant and
metal chelating effects
Actions include anti-inflammatory and
neuro protective effects, relaxant
properties in blood vessels and adaptogenic
activity
KeenMind is unique
Studies indicate cognitive effects are
achieved with no clinically relevant
side effects
Safe for use in children and adults,
including the elderly
Children and students – to facilitate learning
Teachers, lecturers and practitioners –
to increase mental performance
People with high demand careers
Elderly – to delay cognitive decline
The result of 30 years of meticulous
research and development by the
Indian government’s Central Drug
Research Institute (CDRI)
The only Bacopa to contain optimum
levels of the therapeutic bacosides
A and B (55%) as well as other
therapeutically relevant constituents
To be taken with breakfast.
Adults: 2 capsules daily
Children: 1 capsule daily
Ideal uses for KeenMind
Safety
Dosage
KeenMind (CDRI 08)
is clinically proven to:
KeenMind is clinically proven in
double-blind placebo-controlled
Australian studies
2. Background to KeenMind
Bacopa monnieri (Bacopa) is a perennial creeping plant found
in wet, damp and marshy areas in India. Bacopa has been
mentioned in the religious, social and medical treatises of India
since 3000 B.C. Its use as a memory enhancing agent can be
traced back to 1500 B.C. Classical Ayurveda identified the
medicinal properties of Bacopa as being beneficial for mental
disorders leading to memory impairment and as being
efficacious even in total loss of memory.
Bacopa has been used in traditional Ayurvedic medicine for
various indications including memory decline, inflammation,
pain, pyrexia, epilepsy and as a sedative.
Unique Formulation
KeenMind is the Bacopa extract which has been extensively
investigated by the Indian government’s Central Drug
Research Institute (CDRI). Phytochemical analysis of this plant
was first conducted at the CDRI in 1963 and 1965 . As with
most herbal medicines, a complex mix of constituents is
needed for their therapeutic action, as was evidenced in the
case of Bacopa. Many active constituents were identified
including alkaloids, saponins, D-mannitol, betulic acid,
β-sitosterol and stigmasterols, and the steroidal saponins,
specifically Bacosides A and B which are believed to be
essential for the clinical efficacy of this herb. The CDRI
developed the unique standardised extract of Bacopa monnieri
KeenMind (CDRI 08). This broad-spectrum extract is unique as
it contains, along with other non-bacoside active components,
optimum therapeutic levels of bacosides (55% ± 5%); levels
which have not been identified in any other Bacopa product.
While Bacopa has been reported to have many actions, it is
the memory enhancing effects which have attracted most
attention and pharmacological studies have supported these
historical anecdotal claims for Bacopa.
Mode of Action
Although the exact mechanism of action of Bacopa on
cognitive processes has not yet been determined, evidence
suggests that it may modulate the cholinergic system and/or
have antioxidant and metal chelating effects. Other purported
actions include antiinflammatory, neuroprotective, anxiolytic
and antidepressant effects as well as relaxant properties in
blood vessels and adaptogenic activity.
Clinical Studies
Over the last 30 years the CDRI has researched and developed
the modern use of Bacopa. The scientific evidence for the
memory enhancing effects of Bacopa is based on pre-clinical
studies, and confirmed in numerous clinical trials conducted
in humans. Results include:
• Enhanced memory, reduced anxiety and mental
fatigue and increased work output for patients
with anxiety neurosis
• Enhanced memory and improved learning ability
for children
The first double blind placebo-controlled trial for KeenMind
was published in 2001 . This study was conducted in Australia
KeenMind (CDRI 08)
Special extract of Bacopa monnieri
®
Andrea Zangara
BSc (Clinical Psychology)
Research Scholar, Medicinal Plant Research Centre, Newcastle University, UK
Research Fellow, Brain Sciences Institute, Swinburne University, AU
Flordis International Business Development Manager
by Professor Con Stough and colleagues at Swinburne
University to investigate the memory enhancing effects in
46 healthy subjects aged between 18 and 60 years. Results
showed significantly improved speed of visual information
processing, learning rate and memory consolidation, and
decreased anxiety; maximal effects were evident after 12
weeks. Roodenrys and colleagues replicated the memory
enhancing effects of KeenMind in 76 participants aged between
40 and 65 years . They reported a significant decrease in the
rate of forgetting newly acquired information after 90 days of
treatment in a sample of older individuals than previously used
by Stough and colleagues (2001).
The most recent study on KeenMind was published in the
Journal of Phytotherapy in August 2008 . This study of 62
healthy participants was conducted at the Brain Sciences
Institute at Swinburne University in Melbourne Australia.
Cognitive function tests commonly used in dementia trials
(Cognitive Drug Research (CDR) computerised assessment
system) were used to assess the effects of KeenMind compared
to a placebo, in a randomised double blind placebo controlled
trial (the gold standard in clinical research). After 90 days of
treatment with 2 capsules of KeenMind the participants had
significantly improved performance on “working memory”
(the ability to hold information “online” in the brain and
actually do something with that information) and “visual
information processing” (a measure of the ability to sustain
attention). Slowed information processing is one of the most
prominent cognitive deficits in the elderly.
KeenMind is the result of 3 decades of intensive research
worldwide and now 3 clinical studies have confirmed the
potential of this natural product. These rigorously designed
trials have proven that KeenMind improves memory and other
measures of brain function. KeenMind is a ‘rising star’ to be
closely followed in the ongoing research of evidence-based
botanicals for brain health.
Safety
In the studies conducted it appears that the cognitive effects
of KeenMind are achieved with no clinically relevant side
effects, even in children and elderly participants.
Dosage
The capsules are best taken with breakfast. Adults take
2 capsules daily and children can take one capsule daily.
Key clinical information on KeenMind
®
The world’s leading researched and clinically proven Bacopa
monnieri for use in adults and children
Promotes memory and recall, concentration and mental
clarity, clinically proven in Australian published studies
The result of 30 years of meticulous research and
development by the Indian government’s, Central Drug
Research Institute (CDRI)
A unique broad-spectrum extract of Bacopa, and the only
Bacopa to contain optimum levels of the therapeutic
bacosides at 55% ± 5% as well as other therapeutically
relevant constituents; these standards are not available in
any other Bacopa product
1. Chatterjee et al, Ind. J. Chem., 1963, 1:212-215.
2. Chatterjee et al, Ind. J. Chem., 1965, 3:24-29.
3. Singh, R.H . & Sing, L., Res. Ayur. Siddha 1980, 1:133-148.
4. Sharma et al, J. Res.Educ. Indian Med. 1987 1:12.
5. Stough et al, Psychopharmacology (Berl.). 2001, 156(4):481-484.
6. Roodenrys et al 2002. Neuropsychopharmacology 27(2):279-281
7 Stough et al, Phytotherapy Res. 2008 DOI: 10.1002/ptr.2537
References
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3
4
5
6
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