For people not familiar with the card game Set, see its entry on Wikipedia and/or one of the related questions here on Math SE. It might be faster to just play the game a couple of times though, see e.g. this web-based version.
As there are $3^4 = 81$ cards, the maximum number of sets that can be obtained is $3^3 = 27$. I have played the game many times, but never used up all cards. This makes me wonder what the odds are of obtaining $27$ sets. The game usually ends with either $23$ or $24$ sets, but $25$ is not uncommon. It is not possible to end with $26$ sets though, as the remaining $3$ cards will also form a set.
Of course, certain types of sets are easier to spot than others. In addition, this seems to vary from person to person. In practice this might lead to a reduced number of obtained sets — the easier sets tend to have multiple features (number, shape, colour, shading) in common, thus upsetting the balance/distribution of features in the remaining cards. Therefore, it seems best to give priority to sets that have no features in common. This is just my intuition though.
[Edit] Based on one of the comments below I'd like to update the question. Are there any tactics that improve the probability of obtaining $27$ sets?