Questions tagged [human-genetics]
The scientific study of inheritance as it occurs specifically in human beings.
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Compare cell types human iPCS lines and human prefrontal cortex
I'm a bioinformatician with less knowledge in biology.
I'm working with human brain cells. I have 2 different sequencing datasets. One was derived from human iPCS lines, and another was obtained from ...
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Are there any completely, or 'true', Mendelian traits that do not display any polygeny at all?
Recently, I learned about polygenic traits and it got me wondering, are there any truly Mendelian traits where the trait displayed exists in a total binary?
I have looked at some questions on the ...
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How often do humans have two different genomes?
I read:
Two eggs fertilized by two sperm coincided in a uterus and, instead of giving rise to two sisters, they fused to form a single person: Karen Keegan. When she was 52 years old, this woman from ...
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Have there ever been "half-twins" who were halfway between siblings and twins?
Have there ever been two human siblings who were 75% or more genetically related?
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How exactly are the eye color genes related?
How exactly are the gey (maybe aka EYCL1?), bey(2?) (aka EYCL3?), HERC2, and OCA2 genes related to each other? There are numerous sources that explain eye color in terms of OCA2's role in the creation ...
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If race doesn’t exist; why do humans look so different?
I was talking about a speculative new race of humans that could be created with genetic engineering and several people told me that race does not exist and is a social construct. I get what they are ...
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How did the fusion of Chromosome 2 spawn a separate smarter species?
I’m familiar with the evidence that two primate chromosomes fused into human Chromosome 2, and I understand that primates with such a mutation could still breed with those without it.
My question is, ...
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Different hominid species or simply mutated humans?
I am not a biologist, however, I am curious as to how do evolutionary biologists classify a newly discovered hominid fossil as a separate species. If simply the bone structures are a criteria to ...
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What is the most accurate polygenic score for Alzheimer’s disease?
To date, which polygenic score (i.e. which study) has produced the largest effect size for Alzheimer’s prediction in out-of-sample validation?
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What is the exact definition of the term 'trait'?
A trait is a characteristic shown by an organism.
For example a Tt plant would show the 'tallness' trait.
It seems to me that, by analogy, sickle cell anaemia (SCA) carriers should show the 'normal' ...
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Searching for reference regarding the impact of famine on a woman's grandchildren
I was once told that if a woman experiences a famine, her grandchildren will show epigenetic changes because the egg that the intervening mother came from also experienced the famine.
In other words, ...
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Can someone with albinism have red hair with very pale skin and blue eyes?
I have heard of a type of albinism that occurs in races with darker skin that can give people red hair, but in the pictures I've seen, they usually have reddish-brown hair, a medium skin tone, and ...
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Do endogenous retroviruses (ERV) have a high degree of heterogeneity among people?
Endogenous retroviruses (ERV) make up 5~8% of human genome. These ERV are ancient retroviruses which infected germ cells and therefore became parts of our genomes. However, unless the ERV can increase ...
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How does positional memory in fibroblast cells work?
I have a question regarding how positional memory in fibroblasts work, specifically, where the memory comes from/how its made.
For example, the Salamander & other amphibians are able to regenerate ...
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Overlapping annotated regions among repetitive families of human genome
I am studying the repetitive elements in the human genome and I have come to know that some genomic locations are not uniquely described by a single repeat family. What's behind this uncertainty? Does ...
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