I'm running in Windows 10 Pro. Chrome is my default browser.
When I click on the Chrome icon in my taskbar to open it, and then click on any external URL link, for example a link in a Microsoft Teams message, nothing happens. Chrome doesn't open the link.
If I close the browser and then click on the link, it opens a new instance of Chrome and the link comes up, and clicking other links work.
But if I close Chrome and click on the Chrome icon in my taskbar again, it gets back into the bad state where external URL links do not work.