The survey analyzed spending and preferences around nutritional supplements and skincare products. It found that 80% of consumers across generations are highly engaged with both categories, spending on average over $100 per month. Key insights include: (1) Amazon is the most preferred channel for supplements and second most for skincare; (2) consumers spend significantly on the other category as well, showing crossover opportunities; (3) while spending increases with age for supplements, skincare spending is higher for millennials. The survey suggests opportunities around personalization and developing the convenience store channel.
Since last year ended on such a strong note, many of us were optimistic about the prospects for Q1. Though not as strong as the fourth quarter of 2014, the first quarter of 2015 kicked off on a positive note, with 23 technology companies raising US$6.1billion* in proceeds from their IPOs. That’s the second highest first quarter proceeds in the past five years and impressive given the increased US market volatility and consistent with the high pre-IPO valuations we’ve seen recently. Granted, if you look at the year over year comparison, offerings were down 12% and proceeds declined 11%. And sequentially, the number of technology IPOs declined 32% while proceeds fell by 19%. Still, it’s a promising start for 2015. Learn more at www.pwc.com/globaltechipo
*Deal size greater than US$40 million
A.T. Kearney reached out to more than 2,000 executives, business leaders, and heads of strategy functions to discuss their thoughts on the state of strategy today. Our findings indicate that while most leaders continue to believe in strategy, the return on their strategy initiatives has largely eroded over the past decade. In fact, when asked what it takes to secure a prosperous future, more than 80 percent of executives consider agility as important or more important than strategy when it comes to securing a prosperous future. Fortunately, the findings also point to promising ways to reclaim strategy—including using future-focused tools and techniques and engaging the organization in strategy formulation.
The Rapidly Evolving Landscape of Meal Kits and E-commerce in Food & BeverageL.E.K. Consulting
Consumers are increasingly strapped for time, and when they’re shopping for and preparing fresh, healthy food, every extra minute counts. Here’s where meal kits and e-commerce come in: they give consumers control and the ability to personalize their meals, while saving them valuable time otherwise spent on shopping and food prep.
In this webinar, Rob Wilson, Managing Director at L.E.K. Consulting, and The Food Institute will explore the $150 billion land grab of e-commerce sales in food & beverage and the role of meal kits in this rapidly evolving landscape.
Summary: Even in a time of high biopharma valuations, adopting an activist mentality adds rigor to capital allocation and strategic decision-making, improving not just returns to shareholders but long-term value creation. Therefore, biopharma management teams and boards of directors should proactively assess the “fitness” of their capital allocation strategies and their alignment with operational performance goals by taking an outsider’s view of the business even when times are good — and before a material stumble provides a compelling reason for an outsider to act. For more on this topic, go to http://www.ey.com/GL/en/Industries/Life-Sciences/EY-vital-signs-how-fit-is-your-capital-allocation-strategy.
On June 21st, PwC’s Health Research Institute (HRI) released its annual Medical Cost Trend: Behind the Numbers 2017 report. PwC’s HRI anticipates a 6.5% growth rate for 2017—the same as was projected for 2016. The report identifies the key inflators and deflators as well as historical context to better understand the medical cost trend for 2017. Increases in the trend due to utilization of convenient care access points and an uptick in behavioral healthcare benefits for employees are being offset by more aggressive strategies by pharmacy benefit
Joining Forces: Interagency Collaboration and "Smart Power"Booz Allen Hamilton
This document summarizes the findings of a survey of 268 federal employees regarding interagency collaboration and addressing global challenges. Key findings include: 1) While agencies like Defense, State, and USAID share overlapping missions, collaboration is uneven and has not met expectations for some; 2) Budget pressures may increase the need for collaboration but managers are less optimistic it will reduce costs; 3) Smart power approaches remain applicable but support has decreased in some areas; 4) Agencies report having the tools needed but collaborating most effectively with other agencies compared to private/non-profit partners.
The prosperity that Australia enjoys today will be challenged in the next decade. Disruptive technology will create fewer but bigger winners and more losers. Business has to increase its risk appetite, discover new ideas, pursue more radical strategies, and take bigger steps. In the face of adversity, Australia must respond.
The Accelerating Growth of Frictionless Commerce | A.T. KearneyKearney
Traditional payments are being replaced by new "frictionless" options that use customer-provided data to make a purchase without an explicit customer decision.
The Diversity Imperative: 14th Annual Australian Chief Executive StudyPwC's Strategy&
This report provides insight into the 2013 Australian Chief Executive Study findings, compares the results to the global market and identifies trends. Our analysis looks at trends relating to performance and tenure; reasons for CEO turnover; and the number of insider appointments versus outsider appointments.
L.E.K. Consulting recently surveyed more than 200 U.S. brand managers and packaging stakeholders at consumer packaged goods companies to understand their packaging needs and views on trends driving demand.
The survey focused on topics that include:
- Brand trends and their effect on packaging demand
- Shifts within packaging (e.g., new materials, packaging innovations)
- Perspectives on packaging demand (including forecast spend on packaging for their brands)
This Executive Insights analyzes key findings from this proprietary research
A.T. Kearney 2017 State of Logistics Report: Accelerating into UncertaintyKearney
2017 could be a pivotal year for logistics. Demand patterns are shifting, technological advances are altering industry economics, and new competitors are challenging old business models. This year could bring significant moves that reshape individual sectors and even the industry as a whole. Major business combinations, large-scale shifts in distribution flows, deep capacity cuts, massive infrastructure investments–anything is possible. Here are the ten key takeaways from the 2017 State of Logistics report, as well as the four potential scenarios for the future of logistics.
Infrastructure Victoria - AZ/ZEV International ScanL.E.K. Consulting
InfrastructureVictoria for released the Evidence Base that will inform its advice to the Victorian Government on the infrastructure required to support automated and zero emissions vehicles. The Evidence Base includes the findings of ten projects to address key areas, including transport, energy, ICT and urban design. L.E.K. Consulting contributed to this work program, undertaking an international scan of the regulation and technical standards relating to automated and zero emission vehicle technologies.
Right Cloud Mindset: Survey Results Hospitality | Accentureaccenture
The document summarizes survey results from the hotel industry on key functional objectives, technology challenges, and investment priorities over the next two years. Across various departments like guest experience, revenue management, and operations, common themes are emerging such as a focus on contactless technologies, improved data integration, and leveraging AI/ML to enhance capabilities like forecasting and pricing. However, legacy systems are limiting hotels' ability to achieve these objectives due to issues like lack of flexibility, integration challenges, and complexity. Moving to the cloud could help address these barriers by providing scalability, real-time data processing, and breaking down silos to improve collaboration.
The Fourth Annual Global Mobility Study [hyperlink] by L.E.K. Consulting, Vision Mobility and CuriosityCX highlights that there is a much greater uptake of ride-hailing and other new mobility options in India and China than in mature western economies. With relatively low levels of car ownership and less developed public transport systems in these Asian countries, new mobility use is now comparable with and set to overtake traditional transport for a segment of the population.
The FDA and industry: A recipe for collaborating in the New Health EconomyPwC
Pharmaceutical and life science companies and their chief regulator – the FDA – must find new ways to collaborate to meet 21st century demands.
Web Page: http://www.pwc.com/us/en/health-industries/health-research-institute/hri-pharma-life-sciences-fda.jhtml
Unleashing Competitiveness on the Cloud Continuum | Accentureaccenture
Accenture reports how the cloud continuum creates a seamless technology & capability foundation that meets business needs now and in the future. Read more.
5 Opportunities in the Nutritional Supplements IndustryL.E.K. Consulting
According to the third installment of a biennial survey L.E.K. Consulting conducted on the healthy living marketplace, U.S. adult consumers spend, on average, a reported $635 on nutritional supplements each year: $433 on vitamins, minerals and herbal supplements (VMS), and $202 on sports nutrition products. And yet, within both categories, there is still room for further growth.
Indeed, when asked about their prior month’s purchases, just 55% of consumers who make H&W a priority said they bought VMS, and only 25% had purchased sports nutrition products. In other words, for retailers and brands there are some significant opportunities — and even a lurking threat — to be found.
The document summarizes key findings from the 2016 Health & Wellness Study conducted by L.E.K. Consulting. The study examined consumer spending on nutritional supplements, personal care products, and healthy groceries. It found that while millennials are more open to new categories and channels, traditional retailers like drugstores and supermarkets still capture the majority of health and wellness spending, even among millennials. The study also found that most consumers are open to private label products but that boomers remain more loyal to brands.
The document provides an overview and market analysis of the beauty and personal care industry in the US. It discusses key trends such as the growth of premium products outpacing mass products. It also summarizes that the report is available for purchase for $2400 and provides market data and profiles of major companies like Procter & Gamble, L'Oreal, and Estee Lauder.
This marketing plan aims to use social media and digital advertising to encourage more millennials to shop at Whole Foods Market. The plan focuses on creating informative video content for Instagram and TikTok to grow followers by 20% in the first month. It also aims to post 24 videos on TikTok by the end of the campaign. Advertising will be done on Amazon to target the 57% of millennials who are Prime subscribers, as well as on billboards which 71% of Americans look at. The budget allocates around $70,000 for Instagram and TikTok content creation and boosting, $20,000 for Amazon ads, and $120,000 for billboards. The goal is to inform millennials
The document summarizes key findings from the report "Cosmeceuticals in the U.S, 6th Edition" published by Packaged Facts. It states that the US cosmeceuticals market reached $9.7 billion in 2011 and is expected to grow to $11.7 billion by 2016. Younger generations are more appearance-focused and aware of preventative healthcare, opening new marketing opportunities. Products with instant benefits have an edge as consumers expect products to perform quickly given budget constraints. Opportunity is greatest for premium mass market and specialty brands as higher-end spending rebounds following the recession.
This document discusses opportunities and challenges for companies in the health and wellness market. It summarizes the results of a consumer survey on health and wellness preferences. Key findings include: 1) Consumers are willing to pay higher premiums for certain attributes like organic and products with scientific/consumer claims. 2) Taste, freshness, and natural attributes are both important to consumers and command higher premiums. 3) Both millennials and baby boomers represent important demographic groups, with differing preferences, though baby boomers are willing to pay higher premiums overall.
The document provides an overview of the natural products market and the Better Nutrition media platform. Some key points:
- The total natural products market was $166 billion in 2021, with the vitamin/supplement market over $50 billion. Independent retailers represented $11 billion in sales.
- Better Nutrition's total audience across platforms was 740,000 natural product shoppers. The average reader age was 50.4, with an average household income of $113,000.
- Better Nutrition provides opportunities for brands through its magazine, website, social media, podcasts, custom campaigns, and events to reach this engaged health-focused audience.
This document provides a marketing plan for Taos Mountain Energy bars. It begins with a situation analysis of the nutrition/energy bar category, including current users, competitors, and geographic markets. Research objectives and findings are presented next, showing taste and nutrition are top criteria for consumers. Opportunities for the brand are its community origins story and defining its personality. The marketing objective is to increase market share by 2.6% based on category growth trends and consumers' interest in healthy products. Research, budget, strategies, creative concepts and media plans are outlined to achieve this goal.
Food Shopper Insights: Grocery Shopping Trends in the U.S.MarketResearch.com
The document summarizes key findings from a report about grocery shopping trends in the U.S. It found that most grocery shoppers shop at one store, are loyal to that store, and choose it based on convenience and low prices. Many grocery shoppers plan their shopping trips, make lists, and use coupons. In the store, most shop alone and go straight home after shopping. The report provides insights into grocery shopping behaviors to help grocers and food marketers better understand shoppers.
A local business owner in Oxford Mississippi, Good Nutrition manager, Ms. Cynthia Bolden, asked for ideas to make her business prosper further in the Lafayette county community. Good Nutrition is an all natural supplement store and distributor of Nature's Sunshine products.
Running is a form of physical exercise that involves moving at a speed faster than walking. It is a popular recreational activity as well as a competitive sport. Regular running provides significant health benefits such as improved cardiovascular fitness, weight control, and reduced risk of diseases.
Euromonitor International’s Beauty Survey team has published a new case study on “How to target premium beauty buyers”. It offers insight into premium beauty buyers’ grooming habits, product preferences and purchase motivations as premium categories become the key growth engine for global beauty.
This document provides background information on the nutricosmetics and skincare supplements industry in Vietnam. It discusses trends driving growth in the market such as increasing awareness of skincare and willingness to spend on products. Common sales channels for supplements are described, including pharmacies, direct selling, clinics/spas, and online. Government regulations present barriers to entry through lengthy product registration requirements. The document also analyzes consumer preferences for familiar, premium brands and the convenience of supplements matching busy lifestyles.
Retailer Therapy - Campaign for Safe Cosmetics: Ranking Retailers on their Co...v2zq
Retailer Therapy - Campaign for Safe Cosmetics: Ranking Retailers on their Commitment to Personal Care Product & Cosmetics Safety - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
This letter from Team 8 transmits their analysis of the supermarket and grocery retailing industry to various managing partners at Copeland Associates, describing their examination of the overall industry, Whole Foods Market, and The Fresh Market, concluding that Whole Foods is currently better positioned for sustainable growth based on an evaluation against key success factors.
Consumer Trends driving FMCG Innovation in India.pptxArvind Kaila
Urban Indian consumers are increasingly demanding premium products due to rising incomes and urbanization. Companies are responding by launching premium product variants across categories like personal care, food, and beverages. Consumer health consciousness is also shaping product development, with growing demand for herbal and natural products. As consumers adopt digital technologies, companies are using digitization and personalized experiences to engage customers. Major trends expected to impact the FMCG sector include a focus on health and wellness, growth of e-commerce and private labels, and smaller packaging sizes. The Lifebuoy soap brand was able to significantly increase its market share through product innovations, repositioning its messaging around germ protection rather than general health, and expanding into rural markets.
Piramal Pharma's India Consumer Healthcare division is the 11th largest consumer healthcare company in India with a diversified portfolio of 21 brands. Its five core brands account for over 60% of revenue. It has experienced 14% annual revenue growth over the past 9 years through high investment in power brands and expanding e-commerce sales. The company has an asset-light model with end-to-end supply chain capabilities and a multi-channel distribution strategy reaching over 200,000 outlets through a 1,200 strong sales force.
Similar to Top 8 Insights From the 2018 Beauty, Health & Wellness Survey (20)
Spotlight on Media & Entertainment: Box Office TrendsL.E.K. Consulting
In the first installment of our Executive Insights “Spotlight on Media & Entertainment" series – which features our insights in a new impactful visual format – we focus on box office trends. L.E.K.’s Dan Schechter, Gil Moran and Francesco Di Ianni explore the current trends in admissions, movie production, movie ticket prices and whether the 3D movie growth may be coming to an end.
Capitalizing on Opportunities in Fresh Prepared FoodsL.E.K. Consulting
With the increased focus on investing in the perimeter of the grocery store, fresh prepared foods is one of the most interesting growth areas for U.S. grocers. The lines of retail and foodservice have been blurring as grocers realize there is a golden opportunity to capitalize on consumers’ desire for fresh prepared foods and drive foot traffic.
This Executive Insights profiles the high-growth category of fresh prepared foods and why retailers and suppliers alike can expect to find significant opportunities in this market for years to come.
Today’s air, rail and cruise/ferry passengers, conditioned by their interactions with retailers, have different expectations from those held in the past. They expect options during travel, require flexible pricing alternatives and value personalized experiences.
While passengers have idle time during transit, they each have different needs based on who they are, the purpose of their travel, and where they are in their journey. This gives transport providers the unique opportunity to leverage retailer best practices and provide a consistent, personalized customer experience.
In this Executive Insights Spotlight on Transport, L.E.K. examines the changing behaviors of passengers and reveals how transport providers must act and think differently to implement a differentiated merchandising strategy — one that truly captivates their passengers with personalized, bundled content and connectivity offerings and makes the most of their time on board.
Spotlight on Technology: Steering Clear of the IT Danger ZonesL.E.K. Consulting
This document discusses key trends in the IT services market and how vendors can succeed. It finds that companies are increasingly outsourcing IT and migrating to cloud-based services. This favors specialized vendors over generalists. Customers also prefer specialists that can deliver solutions tailored to their industries. To thrive, vendors must focus on differentiated services, improve cloud delivery, and understand customers' business metrics and satisfaction drivers. Those adapting to offer specialized, industry-focused solutions will find the greatest opportunities.
Millennials spend significantly less time watching traditional TV and pay TV compared to non-millennials, and are more likely to use online streaming services. The research found that Millennials across all life stages are more likely to subscribe to services like Netflix, Amazon Prime, and Now TV, and these services are replacing traditional TV viewing among Millennials. In contrast, online streaming services are largely complementary for non-millennials. The research also found strong interest among Millennials in "slim bundles" that offer a selection of popular channels without a full cable/satellite package. This suggests pay TV providers face a growing threat from Millennials' preference for new online media options.
L.E.K. recently conducted the first in-depth analysis of U.K. Millennials’ media consumption habits by life stage, from living at home with parents all the way through to starting their own families. The research, which covers six life stages, shatters the common assumption that, once millennials are older and have their own children, they revert to more traditional media consumption patterns.
Spotlight on Media & Entertainment: Future of Advertising SpendL.E.K. Consulting
In this latest Executive Insights Spotlight on Media & Entertainment series, L.E.K. uncovers the latest in digital advertising spend and the future of industry consolidation.
Spotlight on Media & Entertainment: Virtual RealityL.E.K. Consulting
As new technologies are developed and price points drop, virtual reality (VR) is poised to take off for some applications. In this Executive Insights’ "Spotlight on Media and Entertainment" series, L.E.K. takes a look at the three different types of VR including Super VR, Medium VR, and Casual Mobile VR.
Maximising Value from Airport Investments – Adopting a Truly Active ApproachL.E.K. Consulting
Leading airports are now transforming into customer-led organizations, with real financial benefits and implications for their business models. L.E.K. experience has shown significant benefits from taking this kind of approach. This presentation looks at Australian and New Zealand airports in the context of this transformation - most have begun the journey, but there is further to go.
The New Face of Retail: Retail and Consumer Trends Reshaping the LandscapeL.E.K. Consulting
1) A number of major trends are reshaping the U.S. retail landscape, including demographic shifts toward an older and more ethnically diverse population, the rise of empowered and sophisticated "Uber" consumers, and the blurring of lines between offline and online shopping with omni-channel retailing.
2) Forward-looking retailers are responding to these trends by tailoring their offerings to specific consumer segments through more personalized engagement and one-to-one customer relationships based on robust customer data and analytics.
3) Brands are also adapting by becoming more specialized and focused on niche customer needs, as consumers increasingly demand specialized products and experiences rather than bigger or broader brands.
The document discusses the evolution of consumer expectations and merchandising potential in the airline industry. It notes that consumer expectations have changed significantly since 2007 due to advances in technology and increased digital connectivity. The rise of ancillary revenues is also discussed. The document argues that new distribution capability (NDC) standards will enable airlines to implement powerful new merchandising strategies by determining their own ancillary offerings rather than being constrained by legacy technologies. Ten questions for airlines to consider regarding their ancillary strategy with NDC are then provided.
China: Opportunities and Hot-Spots in the MedTech (Medical Device), Pharmaceu...L.E.K. Consulting
In this presentation, Dr Neale Jones, Partner, L.E.K. Consulting Australia explores the "Opportunities and hot spots for Australian companies in China". This presentation aims to assist Australian companies in the life science industry in entering the China market. This was first presented at the Australia China Life Sciences Summit in Sydney Australia in February 2014.
Opportunities and Challenges Associated with Novel Companion Diagnostic Techn...L.E.K. Consulting
L.E.K. Managing Director Alex Vadas spoke at a BDA workshop on "How to Mature Emerging Technologies into Companion Diagnostics?" See his presentation here.
L.E.K.'s John Moran recently spoke at an NDC in Action conference hosted by Farelogix. He covered topics such as the evolution of consumer expectations, merchandising's potential, why NDC matters and 10 questions to ask about your ancillary strategy. Learn more in his presentation here.
Improving Sales Force Performance and EffectivenessL.E.K. Consulting
The document summarizes key points from a discussion between L.E.K. Consulting and Chief Executive Network on improving sales force performance. It identifies common sales challenges such as misaligned sales strategies, poor lead generation and customer retention. It also outlines critical levers for effectiveness including properly defining sales strategies, improving sales processes, and establishing sales force enablers like performance measurement and an effective sales culture. Case studies show how addressing these areas can accelerate sales growth and profits.
8 Big Reasons Why Loyalty Will Transform the Customer ExperienceL.E.K. Consulting
L.E.K.'s Dan McKone recently presented at the 9th FFP Loyalty Conference 2013 on loyalty transforming the customer experience. Here's his presentation.
Mergers & Acquisitions: What Winners Do to Beat the OddsL.E.K. Consulting
Activity in M&A often comes in bursts. As of the second quarter of 2013, the scent is in the air. Company management is flush with cash, bolstered by buoyant share prices, and face slow prospects for organic growth.
But capturing value by creating a whole that is greater than the sum of its parts is risky. Recently, L.E.K. Consulting analyzed the performance of more than 2,500 M&As between 1993 and 2010 – a period that included two boom and bust economic cycles. L.E.K. found that nearly 60% of companies destroyed shareholder value after the deal closed.
In this new Executive Insights, L.E.K. shares how management can overcome common pitfalls to beat the long odds of creating value through mergers and acquisitions. From identifying the right target to synergy valuation to post-merger integration, winners have shown that with the right approach, value through M&A can be found and captured.
Hunger Games: Strategies for Growing in the Hourglass EconomyL.E.K. Consulting
The document discusses strategies for growing in the "hourglass economy" where purchasing power is shifting to the top and bottom income brackets. It notes that globalization, declining middle-class jobs, and technological changes are driving this phenomenon. The summary provides three key strategies for adapting: 1) Offer items that appeal to both premium and value consumers to attract a wider customer base. 2) Develop signature items that are truly unique and drive traffic. 3) Consider international growth as wealth increases more outside the US. The hourglass economy presents challenges but companies can benefit from embracing strategies to reach consumers across the income spectrum.
A Quiz on Tuberculosis ( conducted as a part of World TB Day 2024 ).pdfJim Jacob Roy
Every year , March 24 is observed as the World TB Day.
This quiz was conducted for medical students on the occasion of TB day to raise awareness about tuberculosis.
These lecture slides, by Dr Sidra Arshad, offer a comprehensive look into cardiac arrhythmias.
Learning objectives:
1. Summarise how an electrocardiogram is read
2. Discuss the electrocardiographic interpretation of:
3. Abnormal voltages of the QRS complex
4. Abnormal sinus rhythms
5. Heart blocks
6. Myocardial ischemia and infarction
7. Electrolytes abnormalities
8. Explain the following terms: reentry, and circus movement
9. Describe the electrical alteration in conduction responsible for fibrillation and flutter
10. Differentiate between fibrillation and flutter based on ECG findings
11. Describe the significance of defibrillation in emergency cardiac situations
Study Resources:
1. Chapter 12, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, https://geekymedics.com/how-to-read-an-ecg/
Lymphoma Made Easy , New Teaching LecturesMiadAlsulami
This lecture was presented today as part of our local Saudi Fellowship program. After three years of direct interaction with trainees and hematologists, I have started to develop an understanding of what needs to be covered. This lecture might serve as a roadmap for approaching and reporting lymphoma cases.
2024 07 12 Do you share my autistic traits_ - Google Sheets.pdfCarriePoppy
I made this spreadsheet when I was waiting for my autism assessment. It helped me determine that I probably have autism. When I did get tested, they (UCLA) told me I do, indeed, have Type 1 autism. You can use this spreadsheet to compare your experience to mine. I am a white woman, AFAB. My diagnosis is Type 1 autism with a pragmatic language deficit.
The impact of CD160 deficiency on alloreactive CD8 T cell responses and allog...MARIALUISADELROGONZL
CD160 is a member of the immunoglobulin superfamily with a pattern of expression
mainly restricted to cytotoxic cells. To assess the functional relevance of the HVEM/
CD160 signaling pathway in allogeneic cytotoxic responses, exon 2 of the CD160
gene was targeted by CRISPR/Cas9 to generate CD160 deficient mice. Next, we
evaluated the impact of CD160 deficiency in the course of an alloreactive
response. To that aim, parental donor WT (wild-type) or CD160 KO (knock-out) T
cells were adoptively transferred into non-irradiated semiallogeneic F1 recipients,
in which donor alloreactive CD160 KO CD4 T cells and CD8 T cells clonally
expanded less vigorously than in WT T cell counterparts. This differential proliferative
response rate at the early phase of T cell expansion influenced the course of CD8 T
cell differentiation and the composition of the effector T cell pool that led to a significant
decreased of the memory precursor effector cells (MPECs) / short-lived effector
cells (SLECs) ratio in CD160 KO CD8 T cells compared to WT CD8 T cells. Despite
these differences in T cell proliferation and differentiation, allogeneic MHC class I
mismatched (bm1) skin allograft survival in CD160 KO recipients was comparable
to that of WT recipients. However, the administration of CTLA-4.Ig showed an
enhanced survival trend of bm1 skin allografts in CD160 KO with respect to WT recipients.
Finally, CD160 deficient NK cells were as proficient as CD160 WT NK cells in
rejecting allogeneic cellular allografts or MHC class I deficient tumor cells. CD160
may represent a CD28 alternative costimulatory molecule for the modulation of
allogeneic CD8 T cell responses either in combination with costimulation blockade
or by direct targeting of alloreactive CD8 T cells that upregulate CD160 expression
in response to alloantigen stimulation
Hemodialysis: Chapter 10, AVF and AVG - Complications (Diagnosis and Manageme...NephroTube - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/akgMSyA06Qg
- Video recording of this lecture in Arabic language: https://youtu.be/HAR3QLj0Q5A
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Heart Valves and Heart Sounds -Congenital & valvular heart disease.pdfMedicoseAcademics
This presentation, authored by Dr. Faiza, Assistant Professor of Physiology at CIMS Multan, delivers an in-depth analysis of heart valves, heart sounds, valvular heart diseases, and congenital heart defects. It begins by distinguishing between normal and abnormal heart sounds, elucidating the timing and causes of the four heart sounds—S1, S2, S3, and S4—and their clinical significance. Detailed explanations are provided on the auscultation sounds that define conditions such as mitral stenosis, mitral insufficiency, aortic stenosis, and aortic insufficiency, with a focus on how these pathological changes affect cardiac mechanics and blood pressure.
The presentation delves into abnormal heart sounds, known as murmurs, categorizing them by their causes, which include valvular lesions, rheumatic fever, aging, congenital heart diseases, viral infections during pregnancy, and hereditary factors. It explores the various types of murmurs, their timing within the cardiac cycle, and their association with specific valvular heart diseases such as stenosis and regurgitation. The intricate relationship between systolic and diastolic murmurs and conditions like anemia and ventricular septal defects is also highlighted.
Further, the presentation covers the pathophysiology of congenital heart diseases, offering a comprehensive review of conditions such as Tetralogy of Fallot and Patent Ductus Arteriosus. It explains the mechanisms of these diseases, their impact on cardiac function, and the clinical manifestations observed in affected individuals. The physiological adjustments of the circulatory system during exercise in patients with valvular lesions are discussed, emphasizing the reduced cardiac reserve and the risk of acute pulmonary edema.
Special attention is given to the compensatory mechanisms of the heart in response to valvular diseases, including the development of concentric and eccentric hypertrophy, increased venous return, and the eventual progression to heart failure. The presentation also examines rheumatic valvular lesions, aging-related aortic stenosis, and the specific challenges posed by these conditions, such as reduced stroke volume and increased metabolic demand.
This thorough exploration of heart sounds, valvular diseases, and congenital defects is designed to enhance understanding and clinical acumen, making it a valuable resource for medical students, healthcare professionals, and educators in the field of cardiology and physiology.
Introduction to Dental Implant for undergraduate studentShamsuddin Mahmud
Introduction to Dental Implant
Dr Shamsuddin Mahmud
Assistant Professor, Department of Prosthodontics
Nortth East Medical College (Dental Unit)
Definition of Dental Implant
A prosthetic device
made of alloplastic material(s)
implanted into the oral tissues beneath the mucosal and/or periosteal layer and
on or within the bone
to provide retention and support for a fixed or removable dental prosthesis.
Classification of Dental Implant
According to placement within the tissue
Blade/Plate form implant
According to Material Used
A) METALLIC IMPLANTS
Commercially pure Titanium
Cobalt chromium molybdenum
Titanium aluminum vanadium
Stainless steel
B) NON-METALLIC IMPLANT
Zirconium
Ceramic
Carbon
According to the ability of implant to stimulate bone formation
A) Bio active
Hydroxyapatite
Tri Calcium Phosphate
B) Bio inert
Metals
Parts of Dental Implant
Implant fixture
Implant mount
Cover screw
Gingival former/healing screw/healing abutment/permucosal extension
Impression post/impression transfer abutment
Implant analogue
Abutment
Fixation screw
Implant Fixture
Implant Mount
Connected to the fixture
Function: used to carry implant from its vital to the prepared osteotomy site either by hand or with a ratchet/ handpiece adaption
Cover Screw
component that is used to cover the implant connection during the submerged healing of the implant
Function: preserves the patency of the connection by preventing any soft tissue ingrowth in the connection
Gingival former/ Healing Abutment/ Healing screw
Screw/ abutment used to create the soft tissue emergence profile around the implant.
Time of placement:
During 1st surgery – One step surgery
After Osseointegration – Two step/stage surgery
Gingival former/ Healing Abutment/ Healing screw
Placed in the site 2-3 weeks for soft tissue healing
Function:
Create gingival emergence profile
Formation of biological width
Impression post/impression transfer abutment
component that is used to trans- fer the implant Hex position and orientation from the mouth to the working cast.
Types
Closed tray
Open tray
Implant analogue/
component which has a different body but its platform and connection are exactly similar to the implant. The analogue is used to replicate the implant platform and connection in the laboratory mode.
Abutment
Abutments
Advantages of Dental Implant Retained Prosthesis
Maintain bone height and width by preventing bone resorption
Maintain facial esthetics
Improve masticatory performance
Improve stability and retention of prosthesis
More esthetics
Increase survival times of prostheses
There is no need to alter adjacent teeth
Improve psychological health
Disadvantages of Dental Implant Retained Prosthesis
Very expensive.
Cannot be used in medically compromised patients who cannot undergo surgery.
Longer duration of treatment
Requires a lot of patient co-operation because of repeated recall visits are essential
INDICATION OF DENTAL IMPLANT
Dental implants can successfully restore all
Prostatitis Severity- How to Determine if You Have Mild Symptoms.pptxAmandaChou9
Do you know how to determine if you have mild prostatitis symptoms. Whether it is mild or severe, natural medicine Diuretic and Anti-inflammatory Pill can help you get rid of it.
These lecture slides, by Dr Sidra Arshad, offer a simplified description of the physiology of insulin and glucagon.
Learning objectives:
1. Describe the synthesis and release of insulin
2. Explain the mechanism of action of insulin
3. Discuss the metabolic functions of insulin
4. Elucidate the effects of insulin on adipose tissue, skeletal muscle, and liver
5. Enlist the factors which stimulate and inhibit the release of insulin
6. Explain the mechanism of action of glucagon
7. Discuss the metabolic functions of glucagon
8. Elucidate the role of insulin and glucagon in glucose homeostasis during the fasting and fed states
9. Discuss the role of other hormones in the glucose homeostasis
10. Differentiate between the types of diabetes mellitus
11. Explain the pathophysiology of the features of diabetes mellitus
12. Discuss the complications of diabetes mellitus
13. Explain the rationale of oral hypoglycemic drugs
14. Describe the features of hyperinsulinemia
Study Resources:
1. Chapter 79, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 24, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 39, Berne and Levy Physiology, 7th edition
4. Chapter 19, Human Physiology, From Cells to Systems by Lauralee Sherwood, 9th edition
5. Chapter 3, Endocrine and Reproductive Physiology, Bruce A. White and Susan P. Porterfield, 4th edition
6. Insulin and Insulin Resistance, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1204764/
7. Complications of diabetes mellitus,
https://pdb101.rcsb.org/global-health/diabetes-mellitus/monitoring/complications
Genetic deletion of HVEM in a leukemia B cell line promotes a preferential in...MARIALUISADELROGONZL
Introduction: A high frequency of mutations affecting the gene encoding Herpes
Virus Entry Mediator (HVEM, TNFRSF14) is a common clinical finding in a wide
variety of human tumors, including those of hematological origin.
Methods: We have addressed how HVEM expression on A20 leukemia cells
influences tumor survival and its involvement in the modulation of the antitumor
immune responses in a parental into F1 mouse tumor model of hybrid
resistance by knocking-out HVEM expression. HVEM WT or HVEM KO leukemia
cells were then injected intravenously into semiallogeneic F1 recipients and the
extent of tumor dissemination was evaluated.
Results: The loss of HVEM expression on A20 leukemia cells led to a significant
increase of lymphoid and myeloid tumor cell infiltration curbing tumor
progression. NK cells and to a lesser extent NKT cells and monocytes were the
predominant innate populations contributing to the global increase of immune
infiltrates in HVEM KO tumors compared to that present in HVEM KO tumors. In
the overall increase of the adaptive T cell immune infiltrates, the stem cell-like
PD-1- T cells progenitors and the effector T cell populations derived from them
were more prominently present than terminally differentiated PD-1+ T cells.
Conclusions: These results suggest that the PD-1- T cell subpopulation is likely
to be a more relevant contributor to tumor rejection than the PD-1+ T cell subpopulation. These findings highlight the role of co-inhibitory signals delivered
by HVEM upon engagement of BTLA on T cells and NK cells, placing HVEM/BTLA
interaction in the spotlight as a novel immune checkpoint for the reinforcement
of the anti-tumor responses in malignancies of hematopoietic origin.
Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges or vermicides
Building a Strong Partnership with Your Medical Teambkling
The relationship you build with your medical team is an important one. Your questions and their expertise often guide the conversations in each appointment. And the needs you have are important to consider as you work together for the best care experience.
Top 8 Insights From the 2018 Beauty, Health & Wellness Survey
1. Beauty, Health & Wellness Survey Analysis
Executive Insights
Top 8 Insights From the 2018 Beauty, Health &
Wellness Survey
Think nutritional supplements and skincare are of interest only
to consumers of a certain age? Think again. According to L.E.K.
Consulting’s third installment of a biennial survey of the healthy
living marketplace, this one focusing on nutrition and skincare,
some 80% of health and wellness (H&W) consumers across
generations — from millennials to baby boomers — are highly
engaged with both categories.
The survey captured insights from more than 1,600 respondents,
representing roughly 77% of the U.S. adult population who
identify with H&W themes, and generated eight key insights across
categories. Together these insights make clear that consumer
interest in nutritional supplements and skincare often lasts a
lifetime.
Top 8 Insights From the 2018 Beauty, Health & Wellness Survey was written by Alex Evans and Maria Steingoltz,
Managing Directors in L.E.K. Consulting’s Consumer Products practice. Alex is based in Los Angeles and Maria is
based in Chicago.
For more information, contact consumerproducts@lek.com.
2. Beauty, Health & Wellness Survey Analysis
Executive Insights
1. They have the spending to prove it
2018 Beauty, Health & Wellness Survey2
On average, consumers spend more
than $100 per month — totaling $1,300
a year — on nutritional supplements
such as vitamins, minerals, herbal and
sports nutrition products, and skincare
products such as creams, lotions and
sunscreens, with a particular emphasis on
semidiscretionary items.
Average annual spend per customer* based on last month’s spend1
0
200
400
800
1,000
1,200
$1,400
Body care and sunscreen
Nutritional supplements and skincare spend by customer type
Personal hand care
Facial skincare
Sports nutrition products
Vitamins, minerals or
herbal supplements
Skincare
Nutritional
supplements
1,278
253
156
216
188
465
Nutrition
customer
Skincare
customer
302
159
335
220
352
1,368
*Outliers beyond $1,000 in the past month were removed
Source: L.E.K. Beauty, Health & Wellness Consumer Survey (February 2018)
3. Beauty, Health & Wellness Survey Analysis
Executive Insights
2. Crossover spending is significant
2018 Beauty, Health & Wellness Survey3
Consumers who primarily shop in one
category also spend more than $450, on
average, in the other category each year.
Nutritional supplements brands, therefore,
don’t want to miss the opportunity
for so-called outer nutrition products,
while beauty brands need to capture
the opportunity for products focused on
“beauty from within.”
Average annual spend per customer* based on last month’s spend1
*Outliers beyond $1,000 in the past month were removed
Source: L.E.K. Beauty, Health & Wellness Consumer Survey (February 2018)
0
200
400
800
1,000
1,200
$1,400
Body care and sunscreen
Nutritional supplements and skincare spend by customer type
Personal hand care
Facial skincare
Sports nutrition products
Vitamins, minerals or
herbal supplements
Skincare
Nutritional
supplements
1,278
253
156
216
188
465
Nutrition
customer
Skincare
customer
335
220
352
1,368
302
159
4. Beauty, Health & Wellness Survey Analysis
Executive Insights
3. Certain generational differences exist
2018 Beauty, Health & Wellness Survey4
Unlike spending on nutritional
supplements, which generally increases
with age, skincare spending is much
higher for millennials than for either Gen
Xers or boomers.
Average annual spend per customer* based on last month’s spend1
*Among customers who have spent more than $0 in the past month in the broader category (nutritional supplements,
functional F&B or skincare)
Source: L.E.K. Beauty, Health & Wellness Consumer Survey (February 2018)
0
200
400
600
800
1,000
$1,200
0
300
600
900
$1,200
Nutritional supplements Skincare
Millennials
567
Gen Xers
677
Boomers Millennials
1,197
Gen Xers Boomers
Body care and sunscreen
Facial skincare
Personal hand careVitamins, minerals or
herbal supplements
Sports nutrition products
244
323
222
455
657
128
529
543
260
394
1,072
387
264
421
768
222
166
380
5. Beauty, Health & Wellness Survey Analysis
Executive Insights
Consumers typically purchase products
in both categories from mass merchants,
Amazon and drugstores — in that order.
The food, drug, mass merchandiser and
convenience stores (FDMC) channel wins
on convenience, while national specialty
channels deliver on quality and trust.
But Amazon has already established
itself as the No. 1 preferred channel for
nutritional supplements, which means
brands have an untapped opportunity
to grow their business with the online
retailer. Amazon Essentials is itself a highly
rated “enthusiast” brand in nutritional
supplements, one that our proprietary
Brand Growth Matrix suggests is also
poised for further growth.
Already the No. 2 preferred channel for
skincare, Amazon appears to also have
significant runway for additional growth
in that category (at the expense, of
course, of the FDMC channel). So, along
with specialty stores, skincare brands need
to invest there as well.
4. Amazon is a force to be reckoned with
Preferred channels by category2
2018 Beauty, Health & Wellness Survey
Note: Weighted based on stated spend
*”Other” for nutritional supplements includes workout facilities, convenience stores, nutrition box subscriptions and other, while “other” for skincare
includes convenience stores, personal care subscriptions and other
**.com of stores included in relevant category
Source: L.E.K. Beauty, Health & Wellness Consumer Survey (February 2018)
5
0
40
60
80
100%
20
10
30
50
70
90
%FDMC 33% 43%
Nutritional
supplements
Skincare
Other*
Healthy grocers
Department stores
Traditional grocers
Specialty nutrition/beauty
and personal care stores
Mass merchants/
warehouses
Amazon
Physicians
Independent distributors
Non-Amazon online**
Drugstores
(6)
Percentage
point change
(skincare vs.
nutrition)
(6)
N/A
0
(1)
(2)
(6)
N/A
0
+2
+8
10
4 2
1
4
6
4
14
15
22
25
4
7
4
4
6
16
23
28
2
6. Beauty, Health & Wellness Survey Analysis
Executive Insights
Millennials already lean heavily toward
Amazon for both nutritional supplements
and skincare, so in order to reach that
demographic, brands need to be great
on that channel. In fact, in nutritional
supplements, Amazon is the channel
of choice for both millennials and Gen
Xers. It has not, however, resonated with
boomers for either category — yet. In the
meantime, brands need to play broadly
across channels to reach boomers, via a
mix of FDMC, specialty stores and online.
5. To reach baby boomers, brands still need to be everywhere
2018 Beauty, Health & Wellness Survey6
Preferred channels for nutritional supplements purchases by consumer segment3
Note: Weighted based on stated spend
*”Other” includes workout facilities, convenience stores, nutrition box subscriptions and other
**.com of stores included in relevant category
Source: L.E.K. Beauty, Health & Wellness Consumer Survey (February 2018)
Millennials Gen Xers Boomers
Other*
Non-Amazon online**
Traditional grocers
Specialty nutrition stores
Amazon
Independent distributors
Healthy grocers
Drugstores
Mass merchants/warehouses
40
20
60
80
100%
0
6
8
5
17
23
34
2
3
2
2
13
5
4
7
3
17
20
29
1
17
5
4
6
17
13
30
6
7. Beauty, Health & Wellness Survey Analysis
Executive Insights
Skincare consumers, according to our
survey, appear more intentional (“first
destination”) than not with their channels
of choice. Nutritional supplements
consumers, meanwhile, appear to base
their choice of channels more on where
they already shop.
6. Channel selection also varies by category
2018 Beauty, Health & Wellness Survey7
Reasons for shopping channels4
Source: L.E.K. Beauty, Health & Wellness Consumer Survey (February 2018)
Nutritional supplements Skincare
I already
shop there
First
destination
Mass
merchant
Drugstore National
specialty
Traditional
grocery
Online
0
20
40
60%
Mass
merchant
Drugstore National
specialty
Traditional
grocery
Online
15
6
21
18
25
30
42
18
4
41
37
17
27
40
50
10
4
77
21
8. Beauty, Health & Wellness Survey Analysis
Executive Insights
7. The convenience store channel remains underdeveloped
2018 Beauty, Health & Wellness Survey8
In nutritional supplements, our Channel
Power Index rating (% shopped vs. %
preferred) for convenience stores suggests
it’s a strong impulse channel that may be
underdeveloped. The same dynamic likely
exists in skincare, too.
Channel Power Index5
Source: L.E.K. Beauty, Health & Wellness Consumer Survey (February 2018)
Ratio of percentage purchased in past month to percentage selected as preferred retailer
0 2 4 6 8 10 12%
Convenience store
“Nutrition box”
subscription
Gym or studio
Healthy grocer
Traditional grocer
Independent distributor
Local health food store
Non-Amazon online
Warehouse club
Drugstore
National specialty
nutrition store
Amazon
Mass merchant
11.5
4.3
4.8
5.9
3.7
3.4
3.4
3.5
3.1
3.0
1.8
1.9
2.1
9. Beauty, Health & Wellness Survey Analysis
Executive Insights
8. What cuts across both nutritional supplements and skincare is personalization
2018 Beauty, Health & Wellness Survey9
Personalization can take many forms. For
some, it means a selection of nutritional
supplements tailored to their individual
health needs. For others, it means a
custom skincare program augmented
by a beauty box delivery each month.
Boomers, according to our survey, are only
slightly less likely than either millennials
or Gen Xers to purchase a skincare or
personalized nutritional supplements
program. Both nutritional supplements
and skincare brands need to address
this large — and largely untapped
— personalization opportunity with
compelling, holistic solutions.
Whatever the form, based on stated
interest, the conservatively estimated
market potential for personalized
products tops $6 billion — $3.2 billion
for nutritional supplements and $3.1
billion for skincare. While some of
this would involve a shift in current
spending, consumers did suggest that
personalization would increase their
overall spend in the category, particularly
in nutritional supplements.
Source: L.E.K. Beauty, Health & Wellness Consumer Survey (February 2018)
Interest in a personalized nutrition program and skincare program6
0
100%
90
80
70
60
50
40
30
20
10
1 (Not interested at all)
3
5
7 (Very interested)
2
4
6
Nutritional
supplements
Skincare
Millennials Gen Xers Boomers
Nutritional
supplements
Skincare Nutritional
supplements
Skincare
2
38
20
23
10
3
3
39
19
19
10
5
4
5
36
19
24
8
5
3
5
31
22
21
11
4
5
8
21
13
16
14
7
7
23
25
16
13
15
7
11
13
10. Beauty, Health & Wellness Survey Analysis
Executive Insights
10
Endnotes
1
Survey question 6: In the past month, approximately how much have you spent on each of the following goods/services? (N=1,635)
2
Survey question 34: Which of the following type of retailer do you consider to be your preferred retailer type for purchasing nutritional supplements? (N=924)/Survey question 47: Which of the following type of retailer do you consider to
be your preferred retailer type for purchasing skincare products? (N=1,242)
3
Survey question 34: Which of the following type of retailer do you consider to be your preferred retailer type for purchasing nutritional supplements? (N=924)
4
Survey question 35: You indicated that you prefer to purchase your nutritional supplements from [X]. What are the top reasons you choose to purchase nutritional supplements from this type of retailer? (N=924)/Survey question 48: You
indicated that you prefer to purchase your skincare products from [X]. What are the top reasons that you choose to purchase facial skincare, personal hand care, body care or sunscreen from this type of retailer? (N=924)
5
Survey question 33: In the past month, which of the following retailers have you purchased nutritional supplements from? (N=924)/Survey question 34: Which of the following type of retailer do you consider to be your preferred retailer
type for purchasing nutritional supplements? (N=924)
6
Survey question 38: What is your interest in a personalized nutrition program providing nutrition recommendations specifically tailored for you as an individual? (N=924)/Survey question 51: What is your interest in a personalized skincare
program specifically customized for your skin type and needs? (N=1,242)
2018 Beauty, Health & Wellness Survey