Daniele Foresti

Daniele Foresti

Cambridge, Massachusetts, United States
852 followers 500+ connections

About

Can a new way of making a drop disrupt the way we think about cancer therapies?

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Experience & Education

  • AcousticaBio, Inc.

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Publications

  • Acoustophoretic Printer

    Science Advances

    Droplet-based printing methods are widely used in applications ranging from biological microarrays to additive manufacturing. However, common approaches, such as inkjet or electrohydrodynamic printing, are well suited only for materials with low viscosity or specific electromagnetic properties, respectively. While in-air acoustophoretic forces are material-independent, they are typically weak and have yet to be harnessed for printing materials. We introduce an acoustophoretic printing method…

    Droplet-based printing methods are widely used in applications ranging from biological microarrays to additive manufacturing. However, common approaches, such as inkjet or electrohydrodynamic printing, are well suited only for materials with low viscosity or specific electromagnetic properties, respectively. While in-air acoustophoretic forces are material-independent, they are typically weak and have yet to be harnessed for printing materials. We introduce an acoustophoretic printing method that enables drop-on-demand patterning of a broad range of soft materials, including Newtonian fluids, whose viscosities span more than four orders of magnitude (0.5 to 25,000 mPa·s) and yield stress fluids (τ0 > 50 Pa). By exploiting the acoustic properties of a subwavelength Fabry-Perot resonator, we have generated an accurate, highly localized acoustophoretic force that can exceed the gravitational force by two orders of magnitude to eject microliter-to-nanoliter volume droplets. The versatility of acoustophoretic printing is demonstrated by patterning food, optical resins, liquid metals, and cell-laden biological matrices in desired motifs.

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  • Acoustophoretic contactless elevation, orbital transport and spinning of matter in air

    Physical Review Letters

    We present the experimental demonstration and theoretical framework of an acoustophoretic concept enabling contactless, controlled orbital motion or spinning of droplets and particles in air. The orbital plane is parallel to gravity, requiring acoustophoretic lifting and elevation. The motion (spinning, smooth, or turnstile) is shown to have its origin in the spatiotemporal modulation of the acoustic field and the acoustic potential nodes. We describe the basic principle in terms of a…

    We present the experimental demonstration and theoretical framework of an acoustophoretic concept enabling contactless, controlled orbital motion or spinning of droplets and particles in air. The orbital plane is parallel to gravity, requiring acoustophoretic lifting and elevation. The motion (spinning, smooth, or turnstile) is shown to have its origin in the spatiotemporal modulation of the acoustic field and the acoustic potential nodes. We describe the basic principle in terms of a superposition of harmonic acoustic potential sources and the intrinsic tendency of the particle to locate itself at the bottom of the total potential well.

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  • Acoustophoretic contactless transport and handling of matter in air

    Proceedings of the National Academy of Sciences of the United States of America

    Levitation and controlled motion of matter in air have a wealth of potential applications ranging from materials processing to biochemistry and pharmaceuticals. We present a unique acoustophoretic concept for the contactless transport and handling of matter in air. Spatiotemporal modulation of the levitation acoustic field allows continuous planar transport and processing of multiple objects, from near-spherical (volume of 0.1–10 μL) to wire-like, without being limited by the acoustic…

    Levitation and controlled motion of matter in air have a wealth of potential applications ranging from materials processing to biochemistry and pharmaceuticals. We present a unique acoustophoretic concept for the contactless transport and handling of matter in air. Spatiotemporal modulation of the levitation acoustic field allows continuous planar transport and processing of multiple objects, from near-spherical (volume of 0.1–10 μL) to wire-like, without being limited by the acoustic wavelength. The independence of the handling principle from special material properties (magnetic, optical, or electrical) is illustrated with a wide palette of application experiments, such as contactless droplet coalescence and mixing, solid–liquid encapsulation, absorption, dissolution, and DNA transfection. More than a century after the pioneering work of Lord Rayleigh on acoustic radiation pressure, a path-breaking concept is proposed to harvest the significant benefits of acoustic levitation in air.

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Honors & Awards

  • Winner of Science as Art Competition

    Material Research Society

    "(Inside Science) -- Most materials scientists dread defects. But sometimes performance-limiting imperfections can be beautiful.

    This past March, Daniele Foresti, a postdoctoral fellow in materials science and mechanical engineering at Harvard, spotted a "pretty epic picture" in the magnified image of a fracture running through some of the layers in a sample a student had made. Technically, the synthesis of the material had failed. But the defect looked like a little lost human, alone in…

    "(Inside Science) -- Most materials scientists dread defects. But sometimes performance-limiting imperfections can be beautiful.

    This past March, Daniele Foresti, a postdoctoral fellow in materials science and mechanical engineering at Harvard, spotted a "pretty epic picture" in the magnified image of a fracture running through some of the layers in a sample a student had made. Technically, the synthesis of the material had failed. But the defect looked like a little lost human, alone in a wide-open landscape.

    Foresti saved the picture and earlier this month it won one of three first place recognitions in the Science as Art competition at the Materials Research Society's conference in Boston.

    Each year the contest honors scientific images that "transcend their role as a medium for transmitting information and contain the aesthetic qualities that transform them into objects of beauty and art."

    https://www.insidescience.org/news/making-art-materials-science

  • Branco Weiss Fellow

    Society in Science

    The Branco Weiss Fellowship – Society in Science provides a platform for exceptionally qualified researchers, demonstrating a willingness to engage in a dialogue on relevant social, cultural, political or economic issues across the frontiers of their particular discipline.

  • Early Postdoc.Mobility Fellowship

    Swiss National Science Foundation

    Early Postdoc.Mobility fellowships are designed for early-career postdocs who wish to enhance their scientific profile by working at a research institution abroad (awarded but declined).

  • ETH Medal for outstanding doctoral thesis

    ETH Zurich

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