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I have a dataset of 950 lipids (X) and want to see if any are correlated with cognitive function (Y). When I try to fit an opls regression model, it errors and says that "No model was built because the first predictive component was already insignificant".

However, when I loop through each of these lipids individually and perform a univariate correlation (Pearson/Spearman), I am left with ~30 lipids that are significantly correlated with cognitive function following FDR correction.

What does this mean? If there are univariate correlations, why am I not able to fit a multivariate model?

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  • $\begingroup$ Which software is this? $\endgroup$
    – Dave
    Commented Apr 2 at 10:16
  • $\begingroup$ I was using the ropls package in R $\endgroup$
    – mkadz
    Commented Apr 4 at 0:19

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