In electromagnetism, the electric displacement field D represents the distribution of electric charges in a given medium resulting from the presence of an electric field E. Its relation to permittivity in the very simple case of linear, homogeneous, isotropic materials with "instantaneous" response to changes in electric field is $$\epsilon = \frac{D}{E}$$ Where $\epsilon$ is the electric permittivity of the material. In general, permittivity is not a constant, as it can vary with the position in the medium, the frequency of the field applied, humidity, temperature, and other parameters.
Other hand, permeability is the measure of magnetization produced in a material in response to an applied magnetic field. The concept of permeability arises since in many materials (and in vacuum), there is a simple relationship between the magnetizing field H and the magnetic flux density B at any location or time, in that the two fields are precisely proportional to each other, so $$\mu = \frac{B}{H}$$ where the proportionality factor $\mu$ is the permeability, which depends on the material and its properties.
Question: Why are the electric permittivity $\epsilon_0$ and $\mu_0$ considered as constant? Could not the properties of vacuum be slightly variable in different regions of the universe or at different scales? (for instance, at a Planck scale)?