Let $f(a,n)=\sum_{S\in C(n)} \prod_{x\in S} \binom{a}{x}$ denote the sum in question.
I can $f(a,n)$ with the help of a generating function:
$$
f(a,n)=[x^n]\frac{1}{1-[(1+x)^a-1]}=[x^n]\frac1{2-(1+x)^a}\tag1
$$
The notation $[x^n]f(x)$ means the coefficient of $x^n$ when $f(x)$ is expanded to its Maclaurin series. This is not especially useful for computations by hand, but it gives a way for a sufficiently powerful computer algebra system to find the number. For example, this Mathematica code computes $f(a,n)$:
SeriesCoefficient[1/(2-(1+x)^a), {x,0,n}]
Furthermore, the generating function quickly tells us the asymptotic growth rate. Standard generating function theory (see generatingfunctionology, section 5.2) implies that
$$
f(a,n)\sim C_a\left[\frac{1}{2^{1/a}-1}\right]^n\qquad \text{as $n\to\infty$}\tag2
$$
for some constant $C_a$. This is because $2^{1/a}-1$ is the root of the denominator of the generating function $1/(2-(1+x)^a)$ which is smallest in absolute value. Furthermore, we can give the constant of proportionality:
$$
C_a=\lim_{x\to (2^{1/a}-1)} \frac{1-x/(2^{1/a}-1)}{2-(1+x)^a}\tag3
$$
The approximation in $(2)$ is quite good, in the sense that the relative error converges to zero exponentially quickly as $n$ increases. In the case $a=5,n=10$,the exact value of $f(a,n)$ is $146{,}163{,}251$, while the approximate value is
$$
C_5\left[\frac{1}{2^{1/5}-1}\right]^{10}
\approx 0.77520\cdot (6.725023)^{10}
\approx 1.461632510167618\cdot 10^8
$$