The inequality is $$\frac{x^3}{(x+y)(x+z)(x+t)}+\frac{y^3}{(y+x)(y+z)(y+t)}+\frac{z^3}{(z+x)(z+y)(z+t)}+\frac{t^3}{(t+x)(t+y)(t+z)}\geq \frac{1}{2},$$ for $x,y,z,t>0$.
It originates from a 3-D geometry problem involving volumes of tetrahedra etc. Actually, it is equivalent with that problem (see Let ABCD be a tetrahedron of volume 1 and M,N,P,Q,R,S on AB,BC,CD,DA,AC,BD s.t. MP,NQ,RS are concurrent. Then the volume of MNRSPQ is less than 1/2.).
The three variables simpler case $$\frac{x^2}{(x+y)(x+z)}+\frac{y^2}{(y+x)(y+z)}+\frac{z^2}{(z+x)(z+y)}\geq \frac{3}{4}$$ can be proved using the Cauchy-Schwarz inequality in "Engel's form".
I have tried variants of Holder type inequalities, until now unsuccessfully.