With the given identity
$(n+\frac12)^6-(n-\frac12)^6=6n^5+5n^3+\frac38n\Leftrightarrow n^5=\frac16\left((n-\frac12)^6-(n+\frac12)^6+5n^3+\frac38n\right)$
We get:
$\sum_{n=1}^N n^5=\sum_{n=1}^N \frac16\left((n-\frac12)^6-(n+\frac12)^6+5n^3+\frac38n\right)$
With basic sum manipulation we derive:
$=\frac16\sum_{n=1}^N (n-\frac12)^6-(n+\frac12)^6+\frac56\sum_{n=1}^N n^3+\frac1{16}\sum_{n=1}^N n$
Note that the first sum is telescoping.
The last sum, is the well known Gaussian sum $\sum_{n=1}^N n=\frac{N(N+1)}{2}$
Depending on what you know, it is also known, that
$\sum_{n=1}^N n^3=\frac{N^2(N+1)^2}{4}$
If you know this result, we are kinda done and you just have to calculate the telescoping sum, which is not difficult and substitute the other sums with known formulas.
If you do not know these formulas, you might proof them first.
This can be down with induction fairly easy, but would a little bit trick the question, in my opinion.
You can also use the same trick to calculate $\sum_{n=1}^N n^3$, by writing it as a telesoping sum.
Then you just need to know $\sum_{n=1}^N n^2$ and $\sum_{n=1}^N n$.
There are many ways, it depends on your background.