I have been doing circuit simulation in HSPICE for research. The final stage of the research is to build an ASIC. The simulation results are often satisfactory. However, I am still in doubt if the designed circuit will perform as per simulation when it is built into an ASIC. I know there are more steps to do in order to design the final ASIC (like PnR, layout, DRC, LVS, etc.). As I still haven't gone through those ASIC design steps, I am doubtful of the simulation results.
How can I be sure of the results? What are the steps I should follow (perhaps avoiding designing the chip if possible?) to be sure that the final designed chip will perform as the HSPICE simulations predict?