All Questions
Tagged with equilibrium biochemistry
18
questions
1
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0
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46
views
Drug dosage determination using dynamical systems
I am a Mathematical Biology student, and recently I have read about various approaches, such as Ordinary Differential Equations (ODEs), used to determine the exact drug dosage and treatment sessions ...
- 21
0
votes
1
answer
87
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Isoelectric Point
How do we derive the formula of isoelectric point?
pI=(pKa1 + pKa2)/2
I read that isoelectric point is defined as the pH at which degree of protonation in amino group is same as degree of ...
- 11
0
votes
2
answers
78
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Why does a small decrease in [ATP] cause a large increase in [AMP]
I was wondering how the reaction catalysed by adenylate kinase and its equilibrium of approximately 1 leads to [AMP] changing greatly with a small change in [ATP]. The below information was provided ...
- 41.2k
-3
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2
answers
1k
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How to determine the charge of amino acid at certain pH? [duplicate]
Problem
What would charge would you expect on alanine when placed in a solution with a pH of 1.00?
Answer
Question
Let's say I am given a certain pH of 2.00 rather than 1.00 for the "acidic ...
- 556
3
votes
1
answer
197
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Constants in Enzyme Kinetics under the Rapid Equilibrium Assumptions
I am new to enzyme kinetics, and I am trying to write an rate equation for a rapid equilibrium random terreactant system. I have been consulting the books Enzyme Kinetics and Mechanism by Cook and ...
CommunityBot
- 1
12
votes
4
answers
1k
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How can a protein folding transition state have zero lifetime?
I'm doing a module on my Biochemistry course looking at protein folding, and in a discussion of [folding] transition states I was a little confused at the thought of a zero-lifetime transition state - ...
- 41.2k
1
vote
1
answer
236
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What is an alternate way of preparing a sodium hydrogen phosphate/sodium dihydrogen phosphate buffer through titrating an acid with a strong base?
So my friend and I are stumped. This is in the context of achieving the sodium hydrogen phosphate/sodium
dihydrogen phosphate buffer by titrating the acid with a strong base.
My friend says the answer ...
CommunityBot
- 1
1
vote
1
answer
181
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How to derive the steady-state solution for simple two-step reaction with differential equations? [closed]
Consider this simple two step reaction, a variant of a Michaelis-Menten type of problem, where $\ce{A}$ and $\ce{B}$ reversibly bind to make $\ce{AB}$, and $\ce{AB}$ and $\ce{C}$ reversibly bind to ...
- 44.3k
0
votes
0
answers
118
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How can the ocean act as a buffer?
I was reading up on the buffering effect of the ocean and I was quite confused about how the buffer is able to do anything. The buffer I will refer to is below:
$$\ce{CO3^{-2} +H2O <=> HCO3 + OH^...
- 31.3k
2
votes
1
answer
318
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Does using stonger soaps help me lose weight?
Soaps are amphiphilic molecules that, practically, removes body oils from the surface of the skin. The body, on the other hand, always replenishes sebum through the sebaceous glands after a certain ...
CommunityBot
- 1
2
votes
1
answer
92
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Relative fraction of population of different enzyme conformations, knowing the rate constants
Say we have an enzyme that has multiple structural conformations, say A, B, C and D. Additionally, we say that the enzyme must go through all conformations, to get to one end to the other, i.e.
$$\...
- 1,548
3
votes
0
answers
89
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Formating chemical equations for proteins binding in multiple configurations
I am working on problems involving protein-protein binding, particularly ones in which two proteins may bind in two or more configurations, and where some of the resultant structures may also bind ...
- 38.4k
16
votes
2
answers
8k
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Is the Gibbs standard free energy always constant?
I am a biochemistry student and we are learning about thermodynamics. Is the Gibbs standard free energy for a reaction always constant? The equation below suggests that it changes with temperature:
$$...
- 71.6k
1
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0
answers
309
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Hemoglobin equilibrium - effect of increased carbon dioxide and lactic acid
The binding of oxygen by haemoglobin giving oxy-haemoglobin is partially regulated by the concentration of $\ce{H3O+}$ and dissolved in $\ce{CO2}$ in blood
$$\ce{HbO2 + H3O+ +CO2<=>H+.Hb.CO2 + ...
- 43k
2
votes
1
answer
2k
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Why don't ions have one equilibrium potential? (Nernst equation)
I know that equilibrium potentials are dependent on the ratio of ion concentrations inside and outside of the cell and temperature. I also know that the equilibrium potential is reached when there is ...
- 22k