Neuroplasticity: Psilocybe mushroom extract (PME) vs synthesized psilocybin (PSIL). And the winner is...
https://lnkd.in/gXD45jSM
You can read the full article for all of the details, but I'd like to summarize and correlate a few important points:
1) Full spectrum psilocybin (PME) taken from whole mushrooms seems to have a more potent and prolonged effect on neuroplasticity compared to PSIL. This makes sense to me as we are taking a complex biological system vs an isolated synthesized compound from that complex organism.
2) PME includes a host of bioactive constituents from the Psilocybe mushroom, not just the psilocybin, including tryptamines, such as baeocystin, aeruginascin, norpsilocin and norbaeocystin; β-carbolines such as harmine and harmaline; and terpenes.
3) There is evidence that Psilocybe mushrooms may been around before "modern" man, and there are even theories, including the Stoned Ape hypothesis, that psychedelic mushrooms have been around for upwards of tens of thousands of years. Nature is the perfect incubator and evolver of complex systems. There is a REASON all of these bioactive compounds were packaged together into the Psilocybe mushroom.
T Colin Campbell wrote about wholism in his book, Whole: Rethinking The Science of Nutrition. It talks about the risks of reductionist thinking. Aristotle knew that the "the whole is greater than the sum of it's parts." We cannot expect to disrupt, isolate, and fragment complex biological systems and see the same responses. It is "the arrogance of man" that believes we can simply reduce the complexities of these fungi down to a single compound. We've seen this in the nutritional world where consuming whole foods can result in lower CV risks, lower mortality, and greater health benefits, that "suddenly" disappear when we isolate supplements, i.e. vitamins, and give them to people in high quantities. In fact, we see death and risk increase when the compound is isolated from the whole.
We live in a reductionist society. We see it in the IP wars where Big Pharma is pouring inordinate amounts of money into "R&D" to isolate, label, and patent versions of psychedelics that are found abundantly in nature. We see it when companies try to strip the subjective psychedelic experience out of psychedelic medicines. We see it discussion groups where the complexities of healing are reduced down to a psychedelic compound or particular healing modality. We see it in the geopolitical arena where the complexities of humanity are reduced down to good vs bad, right vs wrong, this side vs that side.
This article is a beautiful reminder about what is lost when we adopt a reductionist lens instead of honoring the whole as sacred. This article, and perhaps this post, is a gentle reminder for us all to zoom out when we become myopic in our view of life, people, relationships, conflicts, and issues. When we honor the whole, we honor ourselves, our humanity.
#neuroplasticity #psilocybin