This document discusses autism spectrum disorder (ASD) and the role of comparative genomics and interactomics in furthering the understanding of ASD. It highlights that ASD is a highly heritable but genetically complex disorder, with hundreds of genes associated with it. While some genes cause syndromic forms of ASD, the majority of cases have multiple genetic variants contributing to the disorder. Comparative genomics and interactomics studies are helping to elucidate biological pathways and processes involved in ASD by analyzing genetic data from patients. This integrated genomic and systems biology approach is providing new insights into ASD pathogenesis.