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Course Title
How to Protect Yourself against Nanoparticle-Titanium
Dioxide
Lesson Title
Small Particles, Large Problems- Nanoparticle-Titanium
Dioxide
Course Background
A nanoparticle is any material that has at least one dimension
that is less than 100 nanometers. They exhibit unique
properties because of their small size and large comparative
surface area. National Institute for Occupational Safety and
Health (NIOSH) has studied in great detail the toxicity of
incidental exposures to nanoparticles generated from
processes involving combustion, welding, or diesel engines.
However, less is known about nanoparticles that are
intentionally produced (engineered) with diameters smaller
than 100 nanometers and uncertainties exist as to whether
they pose occupational health risks. These uncertainties arise
because of gaps in knowledge about potential routes of
exposure, movement of nanomaterials once they enter the
body, and the interaction of the materials with the body’s
biological systems. Results from existing studies in animals
and humans on exposure to incidental nanoscale and other
respirable particles provide preliminary information on the
possible adverse health effects from exposures to similar
engineered nanomaterials. However, the potential for
nanomaterials to pose health or safety hazards is greater if
the nanomaterials are easily dispersed (such as in powders,
sprays, or droplets) or are not isolated or contained.
Titanium dioxide (TiO2), an insoluble white powder, is used
extensively in many commercial products, including paint,
cosmetics, plastics, paper, and food, as an anticaking or
whitening agent. It is produced and used in the workplace in
varying particle-size fractions, including fine and ultrafine
sizes. Production in the United States was an estimated 1.45
million metric tons per year in 2007 [DOI 2008]. Recently, the
use of nanoscale TiO2 has increased above average and it is
currently the most widely used nanomaterial to date. NIOSH
has determined that nanoscale TiO2 particles have higher
mass-based potency than larger particles, and that
occupational exposure (by inhalation) to nanoscale TiO2
particles should be considered a potential occupational
carcinogen. Previous studies found that, even though there is
no significant evidence of TiO2 exposure and lung cancer
mortality, workers exposed to TiO2 had particle retention of
titanium, silica and other minerals even sometimes years after
cessation of exposure (NIOSH 2011). Rats and mice studies
have shown that TiO2 can cause pulmonary inflammation and
cell damage at sufficiently high surface area doses.
Regulations
Occupational Safety and Health Administration: In workplaces
where workers will be exposed to nanomaterials, the
employer should provide information and training to their
workers. Training should include identification of
nanomaterials the employer uses and the processes in which
they are used; The use and limitations of PPE; Emergency
measures to take in the event of a nanomaterial spill or
release.
OSHA permissible exposure level for TiO2 is 15 mg/m^3.
OSHA recommends that worker exposure to nanoscale
particles of TiO2 not exceed 0.3(mg/m3).
Training Target Group
Employees exposed to Titanium Dioxide in packaging
processes.
Lesson Objective
Give employees a better awareness of titanium dioxide at the
workplace and how they can reduce their exposure to this
nanoparticle.
Learning Outcomes
By the end of the workshop:
• employees should be able to define what are
nanoparticles and titanium dioxide
• employees should be able to list the health hazards
associated with titanium dioxide exposure
• employees should be able to recall the proper PPE to
reduce exposures to titanium dioxide
Evaluation Measures:
 Training reaction survey will be delivered at the end of
training session.
 Learning assessments (Quiz) will be delivered at the
end of training session.
 Training impact assessments will be conducted three
months after the training by written/electronic surveys .
Trainer
Nayila Mulati
Safety Training Program Specialist, System Safety
Department
Duration: 30 mins
Equipment:
PowerPoint; Paper version of Personal Protective Equipment,
if possible actual PPE; Pens and notes distributed to
employees.
Supportive Documents
Quiz; Course evaluation survey; Self -assessment
questionnaire; Training impact assessment
Training Content
 Self -introduction and ice-breakers(5mins)
 Present goal and objective of the training( 2mins)
 Definition of Nanoparticle, Titanium Dioxide(2mins)
 Health risks of Nano-size Titanium Dioxide(2mins)
 Introduction of proper personal protective equipment
included safety goggle, gloves, respirators, and
coats.(5mins)
 Education on Emergency Response (3mins)
 Combination of case study and game: Divide
employees in two to three groups; Give them job
scenario and let them choose proper personal
protective equipment that match for such specific
circumstance; Timing and reward the winning group
with Godiva chocolates or Pizza.(5mins)
 Summarize the topic and distribute employees an
assessment quiz and course evaluation survey.(5mins)
References
[1] OSHA Fact Sheet, Working safely with nanoparticles.
Retrieved from: https://www.osha.gov/Publications/OSHA_FS-
3634.pdf
[2] Titanium Dioxide Material Safety Data Sheet. Retrieved
from: https://www.sciencelab.com/msds.php?msdsId=9925268
[3] NIOSH. NIOSH Pocket Guide to Chemical Hazards
(2010).Retrieved
from:http://www.cdc.gov/niosh/npg/npgd0617.html. September
12, 2014. - See more at: http://www.safecosmetics.org/get-the-
facts/chemicals-of-concern/titanium-dioxide-
2/#sthash.4ykuaYaB.dpuf
[4] NIOSH. Occupational Exposure to Titanium
Dioxide(2011).Retrieved from:
https://www.cdc.gov/niosh/docs/2011-160/pdfs/2011-160.pdf

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  • 1. Course Title How to Protect Yourself against Nanoparticle-Titanium Dioxide Lesson Title Small Particles, Large Problems- Nanoparticle-Titanium Dioxide Course Background A nanoparticle is any material that has at least one dimension that is less than 100 nanometers. They exhibit unique properties because of their small size and large comparative surface area. National Institute for Occupational Safety and Health (NIOSH) has studied in great detail the toxicity of incidental exposures to nanoparticles generated from processes involving combustion, welding, or diesel engines. However, less is known about nanoparticles that are intentionally produced (engineered) with diameters smaller than 100 nanometers and uncertainties exist as to whether they pose occupational health risks. These uncertainties arise because of gaps in knowledge about potential routes of exposure, movement of nanomaterials once they enter the body, and the interaction of the materials with the body’s biological systems. Results from existing studies in animals and humans on exposure to incidental nanoscale and other respirable particles provide preliminary information on the possible adverse health effects from exposures to similar engineered nanomaterials. However, the potential for nanomaterials to pose health or safety hazards is greater if the nanomaterials are easily dispersed (such as in powders, sprays, or droplets) or are not isolated or contained. Titanium dioxide (TiO2), an insoluble white powder, is used extensively in many commercial products, including paint, cosmetics, plastics, paper, and food, as an anticaking or whitening agent. It is produced and used in the workplace in varying particle-size fractions, including fine and ultrafine sizes. Production in the United States was an estimated 1.45 million metric tons per year in 2007 [DOI 2008]. Recently, the use of nanoscale TiO2 has increased above average and it is currently the most widely used nanomaterial to date. NIOSH has determined that nanoscale TiO2 particles have higher mass-based potency than larger particles, and that occupational exposure (by inhalation) to nanoscale TiO2 particles should be considered a potential occupational carcinogen. Previous studies found that, even though there is
  • 2. no significant evidence of TiO2 exposure and lung cancer mortality, workers exposed to TiO2 had particle retention of titanium, silica and other minerals even sometimes years after cessation of exposure (NIOSH 2011). Rats and mice studies have shown that TiO2 can cause pulmonary inflammation and cell damage at sufficiently high surface area doses. Regulations Occupational Safety and Health Administration: In workplaces where workers will be exposed to nanomaterials, the employer should provide information and training to their workers. Training should include identification of nanomaterials the employer uses and the processes in which they are used; The use and limitations of PPE; Emergency measures to take in the event of a nanomaterial spill or release. OSHA permissible exposure level for TiO2 is 15 mg/m^3. OSHA recommends that worker exposure to nanoscale particles of TiO2 not exceed 0.3(mg/m3). Training Target Group Employees exposed to Titanium Dioxide in packaging processes. Lesson Objective Give employees a better awareness of titanium dioxide at the workplace and how they can reduce their exposure to this nanoparticle. Learning Outcomes By the end of the workshop: • employees should be able to define what are nanoparticles and titanium dioxide • employees should be able to list the health hazards associated with titanium dioxide exposure • employees should be able to recall the proper PPE to reduce exposures to titanium dioxide
  • 3. Evaluation Measures:  Training reaction survey will be delivered at the end of training session.  Learning assessments (Quiz) will be delivered at the end of training session.  Training impact assessments will be conducted three months after the training by written/electronic surveys . Trainer Nayila Mulati Safety Training Program Specialist, System Safety Department Duration: 30 mins Equipment: PowerPoint; Paper version of Personal Protective Equipment, if possible actual PPE; Pens and notes distributed to employees. Supportive Documents Quiz; Course evaluation survey; Self -assessment questionnaire; Training impact assessment Training Content  Self -introduction and ice-breakers(5mins)  Present goal and objective of the training( 2mins)  Definition of Nanoparticle, Titanium Dioxide(2mins)  Health risks of Nano-size Titanium Dioxide(2mins)  Introduction of proper personal protective equipment included safety goggle, gloves, respirators, and coats.(5mins)  Education on Emergency Response (3mins)  Combination of case study and game: Divide employees in two to three groups; Give them job scenario and let them choose proper personal protective equipment that match for such specific circumstance; Timing and reward the winning group
  • 4. with Godiva chocolates or Pizza.(5mins)  Summarize the topic and distribute employees an assessment quiz and course evaluation survey.(5mins) References [1] OSHA Fact Sheet, Working safely with nanoparticles. Retrieved from: https://www.osha.gov/Publications/OSHA_FS- 3634.pdf [2] Titanium Dioxide Material Safety Data Sheet. Retrieved from: https://www.sciencelab.com/msds.php?msdsId=9925268 [3] NIOSH. NIOSH Pocket Guide to Chemical Hazards (2010).Retrieved from:http://www.cdc.gov/niosh/npg/npgd0617.html. September 12, 2014. - See more at: http://www.safecosmetics.org/get-the- facts/chemicals-of-concern/titanium-dioxide- 2/#sthash.4ykuaYaB.dpuf [4] NIOSH. Occupational Exposure to Titanium Dioxide(2011).Retrieved from: https://www.cdc.gov/niosh/docs/2011-160/pdfs/2011-160.pdf