Cardiovascular system
- 2. The Closed Circulatory System
•Humans have a closed circulatory system,
typical of all vertebrates, in which blood is
confined to vessels and is distinct from
the interstitial fluid.
–The heart pumps blood into large vessels
that branch into smaller ones leading into the
organs.
–Materials are exchanged by diffusion
between the blood and the interstitial fluid
bathing the cells.
- 3. The HEART
The Heart- cardiac
muscle tissue
–highly interconnected
cells
–four chambers
•Right atrium
•Right ventricle
•Left atrium
•Left ventricle
- 4. Functions of the Heart
• Generating blood pressure
• Routing blood
– Heart separates pulmonary and systemic
circulations
• Ensuring one-way blood flow
– Heart valves ensure one-way flow
• Regulating blood supply
– Changes in contraction rate and force
match blood delivery to changing
metabolic needs
- 7. Chambers
• 4 chambers
• 2 upper chambers= Atria
– Between is interatrial septum
– Contains fossa ovalis- remnant of foramen
ovalis
• 2 lower chambers = ventricles
– Between is interventricular septum
• Wall thickness depends on work
load
– Atria thinnest
– Right ventricle pumps to lungs & thinner
- 9. Conduction System of the Heart –
Sinoatrial (SA) Node
• Heartbeat is initiated by the cardiac muscle
fibers of the sinoatrial (SA) node.
– located in the posterior wall of the right atrium,
adjacent to the entrance of the superior vena
cava
• Act as the pacemaker.
– rhythmic center that establishes the pace for
cardiac activity
• Initiates impulses 70 - 80 times per minute.
• STETHOSCOPE – instrument that hears
the heartbeat (lub-dub)
- 10. Circulations•Pulmonary circuit
–responsible for
carrying deoxygenated
blood from the right
side of the heart to the
lungs, and then
returning the newly
oxygenated blood to
the left side of the
heart.
•systemic circuit
- responsible for
carrying oxygenated
blood from the left side of
the heart to the different
- 13. The BLOOD VESSELS
A network of tubes
–Arteriesarterioles move away from the heart
•Contains oxygenated blood (except the pulmonary
artery)
–Capillaries – where gas exchange takes place.
–VeinsVenules moves towards the heart
•Skeletal Muscles contract to force blood back
from legs
•One way values
•When they break - varicose veins form
•Contains deoxygenated blood (except the
aorta)
- 15. The BLOOD
• Considered a connective tissue: contains
– Cells
– a liquid ground substance (called plasma)
– dissolved protein fibers.
• About four times more viscous (or thicker)
than water.
• Temperature of blood is about 1°C higher
than measured body temperature.
- 17. Composition
• Connective tissue-Two parts
– Plasma = soluble materials (~55%)
– Formed Elements = cells (~45%)
• Percent occupied by red blood
cells (RBC) = hematocrit (Hct)
• White blood cells (WBC) ~1%
- 18. A. Plasma
Liquid portion of the
blood. Contains clotting
factors, hormones,
antibodies, dissolved
gases, nutrients and
waste
- 19. B. Erythrocytes - Red
Blood Cells
–Carry hemoglobin and
oxygen. Do not have a
nucleus and live only
about 120 days.
–Can not repair
themselves.
- 20. C. Leukocytes – White
Blood cells
–Fight infection and are
formed in the bone marrow
–Five types – neutrophils,
lymphocytes, eosinophils,
basophils, and monocytes.
- 21. •D. Thrombocytes –
Platelets.
–These are cell fragment
that are formed in the
bone marrow from
magakaryocytes.
–Clot Blood by sticking
together – via protein
fibers called fibrin.
- 22. Blood Types
• Surface antigens- react with
antibodies
• Two antigens = A & B
• If have only A –type A
• If have only B –type B
• If neither then Type O
• Blood usually has antibodies that can
react with antigens
– e.g. anti-A antibody or anti-B antibody
• You don’t react with your own antigens
- 23. Transfusions
• If mismatched blood given antibodies
bind to it and hemolyze cells
• Type AB has no AB antibodies so can receive
any ABO type blood called Universal
recipients
• Type O have neither antigen so can donate to
any other ABO type called Universal donors
- 25. Rh Blood Group
• Antigen discovered in rhesus monkey
• If have antigen- Rh+
• Normally don’t have antibodies
• antibodies develop after the first
exposure from transfusion
- 26. Checking Circulation- Pulse
• Pulse in arteries = HR
– Use radial artery at wrist,
– carotid artery,
– brachial artery
• Tachycardia = rapid rest rate (>100
bpm)
• Bradycardia= slow rest rate (<50
bpm)
- 27. Blood Pressure
• Use sphygmomanometer
– Usually on brachial artery
• Raise pressure above systolic-
– stop flow
• Lower pressure in cuff until flow just
starts
– first sound Systolic Pressure
• Lower until sound suddenly gets faint
Diastolic pressure
• Normal values <120 mmHg for systolic
& < 80 mmHg for diastolic
- 28. Blood Pressure
• Force/unit area blood places on
the inside wall of a blood vessel.
• Measures in mmHg
• Sphygmomanometer: device to
measure blood pressure.
• Systolic blood pressure
(contraction)
• Diastolic blood pressure
(relaxation)
• 120/80 mmHg
- 29. Disorders of the Cardiovascular System
• Anemia - lack of iron in the blood, low RBC count
• Leukemia - white blood cells proliferate wildly,
causing anemia
• Hemophilia - bleeder’s disease, due to lack of
fibrinogen in thrombocytes
• Heart Murmur - abnormal heart beat, caused by
valve problems
• Heart attack - blood vessels around the heart
become blocked with plaque, also called myocardial
infarction
- 30. Effects of Aging on the Heart
• Gradual changes in heart function,
minor under resting condition, more
significant during exercise
• Hypertrophy of left ventricle
• Maximum heart rate decreases
• Increased tendency for valves to
function abnormally and arrhythmias to
occur
• Increased oxygen consumption
required to pump same amount of
blood
- 31. Stiffening of the aorta
Atherosclerosis
Arterosclerosis
Aerobic exercise (longer than 20 mins)
strengthens cardiovascular system