This document summarizes a presentation about open science and data infrastructure in Africa. It discusses several large-scale scientific projects that generate massive amounts of data, such as the Square Kilometre Array telescope. It also profiles initiatives like H3ABioNet that aim to facilitate genomic research and data sharing across Africa. The presentation advocates for the development of an African Open Science Platform to help coordinate open science activities on the continent and promote policies around open data, research collaboration, and cyberinfrastructure. It outlines some focus areas and stakeholders in building out such a platform to support data-intensive research.