Huang, Yoon et al. provide a comprehensive single cell protein atlas of CEACAM1 expression on immune cells in human melanoma samples. Their analysis identifies an association between increased CEACAM1 expression and treatment-resistant disease.

Yang, Zhou et al. undertake a nationwide cross-sectional study of weather and mortality. Mortality risks of compound daytime-nighttime temperature extremes are stronger than those occurring only in daytime or nighttime, with patients with ischemic heart disease and respiratory disease being particularly vulnerable to adverse temperature events.

Haag et al. examine the theories of persons with multiple sclerosis (MS) about the causes of MS using natural language processing techniques. Their study identifies unique topics and highlights the role of mental health and the need for an open dialogue about the scientific and mental health aspects of MS.

Rabea et al. assess spinal muscular atrophy (SMA) incidence in Arab countries where rates of consanguinity are high. Findings from SMA newborn screening in Emiratis underscore a need for universal premarital screening.

Hadley et al. characterize COVID-19 re-infections utilizing electronic health record study cohort data of over 3 million patients. They find severe initial COVID-19 infection linked to severe reinfections and less frequent long COVID diagnosis after reinfection.

Zang et al. use RECOVER EHR data to study Long COVID risk factors and apply mathematical modeling to predict the development of long COVID conditions. They find that severe acute SARS-CoV-2 infection, being underweight, and having baseline comorbidities are likely associated with increased risk of having Long COVID.

Han et al. present a framework to map the clusters of multimorbidity progression by examining the bi-directional causal progress between hundreds of diseases. This provides a comprehensive picture of how one disease influences and is influenced by the development of others, and how they form clusters of disease trajectories.

Somani, Jain et al. evaluate public perceptions of glucagon-like peptide-1 receptor agonists with large language model-based analysis of social media posts. Sentiments were neutral-to-positive, and discussions included use in weight loss, side effects, and issues with access and supply.

Sulaiman et al. performed a systematic review and meta-analysis of the evidence on global prevalence and correlates of mpox vaccine acceptance and uptake in different populations. They show large variation in vaccination rates across the six WHO global regions for different population sub-groups, suggesting a tailored approach to vaccination.

Pietzner et al. demonstrate the need for a holistic approach to identify people at highest risk for severe COVID-19 based on integrating health records across primary and secondary care. Integrating human genetic evidence, they find that the symptoms of malaise and fatigue are a largely unrecognized risk factor for severe COVID-19.

Chisholm-Burns et al. discuss the substantial shortage of organs available for transplantation, with disparities in access amongst some racial and ethnic groups. The authors suggest that while xenotransplantation can potentially increase organ availability, it also has the potential to further embed inequities in transplant care.

Thirunavukkarasu et al. discuss how standard lifestyle interventions prove ineffective in preventing type 2 diabetes in individuals with isolated impaired fasting glucose, a highly prevalent prediabetes phenotype globally. They propose low-calorie diets as a promising strategy for diabetes prevention in this high-risk population.

Zhang et al. discuss how artificial intelligence (AI) can be used to optimize clinical trial design and potentially boost the success rate of clinical trials. AI has unparalleled potential to leverage real-world data and unlock valuable insights for innovative trial design.

Ivancovsky-Wajcman et al. outline the need for a holistic preventive hepatology approach, involving social nutrition and social prescribing, to address the public health threat of metabolic dysfunction-associated steatotic liver disease (MASLD). They argue that this will facilitate individuals’ engagement in behavioural modifications to treat MASLD.

Macharia et al. discuss a Communications Medicine article on global healthcare accessibility and the impact of the COVID-19 pandemic. They outline strengths in the comprehensive approach taken to studying revealed versus potential spatial accessibility, plus some limitations and wider context with which the results can be interpreted.

Pallett et al. discuss the impact of human conflict on development of antimicrobial resistance. They overview approaches to limit the spread of antimicrobial resistance, using the ongoing conflict in Ukraine as an example of the challenges and opportunities.