It turns out that it's pretty straightforward. Did you see my posted answer?

Have you installed this package? It adds syntax highlighting, but I don't know if it adds a Run option. VBSEdit is the really the gold standard for editing and debugging VBScript code. It provides direct code execution with debugging.

Have you looked into other browsers, or special browser configurations, such as Firefox kiosk mode?

You might find this to be easier: RunHidden

All the sort options are available under the right-click menu, but the headers are a bit more convenient.

You could first try a Repair Install.

Can you post a screenshot of the error? There may be a clue there that's missing from your description of the error. It might help to re-register vbscript.dll. Are all machines running 64 bit Windows? Please also note that the usual corporate approach is that if you can't fix it quickly, and it's only happening on one machine, you re-image and move on.

Maybe you were thinking of SetLocale. That only tells the script what locale (aka culture) you're using within the script, typically so it can correctly interpret a date string. It has no effect on the user or machine configuration.

That's a Notepad2 screenshot. Original Notepad2. Current Notepad2.

Add start so the cmd window doesn't remain on screen: cmd.exe /c start C:\PathToShortcut\Something.lnk. There will still be a brief cmd window flash using this technique. Another option is: explorer.exe C:\PathToShortcut\Something.lnk. But note that the explorer option does not work if you also need to pass a path using %1 or %v and it uses more memory.