I dont think you are likely to achieve a good outcome using Office based applications. this applies to Ms office just as much to Libre Office or most others I have worked with.
PDF conversions by non compliant PDF rendering systems (and that includes some major players such as Firefox or Google docs and HTML renderings) will assume a screen resolution of 96dpi or 72dpi for import so even if you export at 300 the result will be "fuzzy".
to put that into perspective I generated a pixel perfect 4500x3600 image and used LOD import where it is imported as if 96 dpi (it would not matter and be just the same even if using some other Well known graphics apps).
The image on the left is the original. and for comparison I exported the BMP at 4500x3600 by upscale 3.125 (300/96) and deliberatly used that for a new PDF to make a comparison on the right.
I used as many equivalents as possible to ensure the round trip was closest and what happens is here.
![enter image description here](https://cdn.statically.io/img/i.sstatic.net/4PFEN.png)
Noticeably there is often a pixel shift such that part of the left edge is not present in the right hand copy (minor issue to loose 1 pixel width, but for a grid or graticule can be critical)
More importantly the size gets bloated by the anti-alias effects.
Most importantly the true resolution of artwork is lost.
By comparison an image based graphics app at similar zoom will usually see it like this
![enter image description here](https://cdn.statically.io/img/i.sstatic.net/bqQLL.png)
But retain Pixels as per one by one placements.
![enter image description here](https://cdn.statically.io/img/i.sstatic.net/JRoVs.png)