I disabled CSM and enabled secure boot on my Gigabyte Aorus b550 AC with a EVGA GTX 1080.
Every time I boot up my machine, it boots straight into Windows (dual-boot system with ReFind as bootloader) without prompting me with a BIOS flash screen.
If I try to enter the BIOS (spam the delete key right after pressing the power button), my machine powers up (LED lights, fan spin, everything) but there's no video output. I have 2 displays connected with DisplayPort.
I only found a temporary fix, which is to reset the BIOS and keep CSM enabled. This allows me to enter the BIOS again but doesn't enable secure boot.