I've crunched the numbers and can answer; my gut feeling was good, and in all 299 manned launches, no crew has a greater combined amount of time in space. My top 10 crew experience table is:
- Soyuz TMA-05M - 723.009 days : 3 Crew
- Soyuz TM-31 - 680.813 days : 3 Crew
- STS-102 - 651.844 days : 7 Crew
- Soyuz TMA-6 - 646.175 days : 3 Crew
- STS-134 - 635.706 days : 6 Crew
- Soyuz TMA-01M - 630.625 days : 3 Crew
- Soyuz TMA-3 - 602.949 days : 3 Crew
- Soyuz TMA-04M - 598.083 days : 3 Crew
- STS-88 - 572.844 days : 6 Crew
- Soyuz TM-33 - 561.703 days : 3 crew
The growth in spaceflight experience per launch can be illustrated on this graph:
@Nickolai raised an interesting point; what happens if you measure number of previous launches averaged by crew size, you get the following experience rankings:
- Soyuz TMA-3 - 9 launches : 3 Crew (3.00)
- Soyuz TM-21 - 8 launches : 3 crew (2.67)
- Soyuz TM-31 - 8 launches : 3 crew (2.67)
- Soyuz TMA-11M - 8 launches : 3 crew (2.67)
- Soyuz TMA-16M - 8 launches : 3 crew (2.67)
- STS-80 - 13 launches : 5 crew (2.60)
- STS-103 - 18 launches : 7 crew (2.57)
- Soyuz T-13 - 5 launches : 2 crew (2.50)
- STS-79 - 15 launches : 6 crew (2.50)
- STS-88 - 15 launches : 6 crew (2.50)
The growth is launch experience per launch can be shown in the following graph:
So, we can conclude, the TMA-16M crew are the most experienced by space experience but amongst the most experienced by launch counts.