I read this novel about 15-20 years ago, most probably somewhere online (though can't remember where). It was fairly new at the time (not older than 5-10 years). So I guess mid-90s to early 00s.
It starts around our own present and goes on far into the future. People are trying to use nanobots to increase human lifespan, and even achieve immortality. In this, they are secretly and (if I remember correctly) subtly guided by some aliens.
The aliens are not benevolent, they have their own plans and are only using humans as pawns to set their plans into motion.
There are several stories of different people from different times, but they are all somehow connected. I remember that the big event that connects most of them is some sort of pandemic that kills a large part of the population - it was connected to the nanobot project, but I can't remember if it was intentional or a side effect.
I also distinctly remember a chapter set far into the future where a little girl is killed by those aliens while being in a cave (not sure for what reason, though - but I think she may have overheard them conspiring about something with their human collaborators).
I tried Googling, but can't find it. It's not Crichton's "Prey", though after reading the plot, it does have some similarities. I have a pretty bad memory, but this one I clearly remember, I probably read it more than once.