Questions tagged [serotonin]
For questions about the neurotransmitter serotonin's role in behavior and cognition.
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Does 5HT neccessarily desensitize at long term use of SSRIs?
I have a knowledge gap which I can't find many papers about.
I know that receptors like 5HT desensitize when a prolonged increased1 availability is present because the brain tries to maintain ...
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How do SSRIs interact with MDMA?
I'm not sure if I understand the synergetic effects of MDMA and SSRIs correctly.
According to PMC81503 "It is clear, however, that the increase in the net release of serotonin (and possibly ...
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Does dopamine suppress serotonin production?
In a youtube video in spanish, I heard that dopamine suppress serotonin production. Is that true?
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How can someone enjoy something without dopamine?
In this video, Andrew Huberman says people and even animals with depleted dopamine levels can still enjoy stuff.
How does one enjoy without dopamine? Isn't it the pleasure chemical?
Can serotonin, ...
user31290
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How does acute tryptophan depletion work?
The literature online about this practice is very poor. The theory goes like this:
A mix of amino acids that does not include tryptophan will lower the proportion of tryptophan in the bloodstream.
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What are the pharmacodynamics (Ki nM) of the monoamine neurotransmitters?
Ok, so any psychoactive drug will have different affinities for different receptor types. For instance, sertraline has an extreme affinity for the SERT and very little affinity for the 5-HT1A receptor....
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Any statistics on the likelihood of, consumption frequencies and dosages required for serotonin syndrome to occur with LSD?
This may be too obscure of a question to have sufficient, if any, statistics on it. If that's the case, any relevant information is appreciated.
From what I've gathered, very high doses and/or very ...
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Non-serotonergic hallucinogens
According to this article, agonism of the 5-HT$_{2A}$ is necessary for hallucinogenesis. Now, not all hallucinogens are primarily serotonergic, but does there exist hallucinogens that aren't at all ...
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What is meant by "serotonergic" in "serotonergic psychedelics"
"Serotonergic psychedelics" is apparently a sub-class of psychedelics. Now, I believed that the pharmacological definition of psychedelics is that they all agonise 5HT receptors, especially ...
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How do psychedelics work? [duplicate]
I realize my question is more of a pharmacological one than a neuroscientific one, but I didn't know where else to ask this question.
As far as I've read, there's two components to how psychedelics ...
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Measuring serotonin in the brain with a sample of spinal fluid
Is it possible to measure serotonin with a sample of spinal fluid?
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Causality regarding neurotransmitter imbalance and depression
Neurotransmitter imbalances are blamed for various psychiatric conditions (depression, ADHD, etc). Clearly plasma levels of neurotransmitters are confirmed to be abnormal in some people with such ...
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What determines whether a monoamine neurotransmitter is recycled or broken down by MAO?
When a neurotransmitter detaches from the receptor and is returned to the neuron via the transporter, what are the primary factors that influence whether that molecule is re-stored in a vesicle by ...
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How does the body respond to having excess levels of neuronal, not synaptic, serotonin?
If a person consumes large amounts of 5-HTP or SAM-e resulting in elevated serotonin levels in their synaptic vesicles, how is this excess offloaded? What is the average rate of clearance?
All the ...
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What can happen if a human takes SB-243213?
SB-243213 acts as a selective inverse agonist for the 5-HT2C receptor.
The 5-HT2C receptor is one of many 5-HT receptors which are receptors that bind serotonin, and seems to play a major role in ...
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