I do not see any straightforward way of modifying the style of an individual cell in a QgsLayoutItemTextTable
. To be honest, I'm not sure that level of customisation is supported. There are methods such as setContentTextFormat() and setCellStyle(), but they are applied to either the entire table or a cellStyleGroup e.g. odd or even rows/columns, first or last row/column etc.
So this is not exactly answering your original question, but I would strongly recommend you to use a QgsLayoutItemManualTable instead.
As far as I can see, the main difference is that the table contents is composed of QgsTableCell objects which support full customisation such as background color, text format etc. at an individual cell level.
Here is a minimal example to create a manual table with some content and add it to a layout:
tbl_items = [['Item 1', 'Item 2', 'Item 3'],
['Item 4', 'Item 5', 'Item 6']]
tbl_contents = [[QgsTableCell(c) for c in r] for r in tbl_items]
l = QgsProject.instance().layoutManager().layoutByName('Test Layout')
t = QgsLayoutItemManualTable.create(l)
l.addMultiFrame(t)
t.setTableContents(tbl_contents)
# Base class for frame items, which form a layout multiframe item.
frame = QgsLayoutFrame(l, t)
frame.attemptResize(QgsLayoutSize(100, 25), True)
t.addFrame(frame)
l.refresh()
Then you can modify an individual cell format like so:
layout = QgsProject.instance().layoutManager().layoutByName('Test Layout')
frame = [f for f in layout.items() if isinstance(f, QgsLayoutFrame)][0]
# Access the table item
tbl = frame.multiFrame()
# Retrieve the table contents (nested lists)
tbl_contents = tbl.tableContents()
# Define the column & row indexes for your target cell
# *mind that the indexing starts from zero
col_idx = 1
row_idx = 1
# Retrieve the cell content
cell_content = tbl_contents[row_idx][col_idx].content()
# Create a new cell with the same content
new_cell = QgsTableCell(cell_content)
# Create a new text format object with font & color of your choice
txt_format = QgsTextFormat()
txt_format.setFont(QFont('Times'))
txt_format.setSize(12)
txt_format.setColor(QColor(0, 255, 0))
# Set text format to new cell
new_cell.setTextFormat(txt_format)
# Place the new cell in the table contents matrix
tbl_contents[row_idx][col_idx] = new_cell
# Set the modified contents to the table
tbl.setTableContents(tbl_contents)
# Refresh the layout
layout.refresh()
Before:
![enter image description here](https://cdn.statically.io/img/i.sstatic.net/eiRuN.png)
After:
![enter image description here](https://cdn.statically.io/img/i.sstatic.net/u8EFj.png)