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ZBTB1

From Wikipedia, the free encyclopedia
ZBTB1
Identifiers
AliasesZBTB1, ZNF909, zinc finger and BTB domain containing 1
External IDsOMIM: 616578; MGI: 2442326; HomoloGene: 8974; GeneCards: ZBTB1; OMA:ZBTB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001123329
NM_014950

NM_178744
NM_001364323

RefSeq (protein)

NP_001116801
NP_055765

NP_848859
NP_001351252

Location (UCSC)Chr 14: 64.5 – 64.53 MbChr 12: 76.42 – 76.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.[5]

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.[6][7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126804Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033454Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger and BTB domain containing 1".
  6. ^ Siggs OM, Li X, Xia Y, Beutler B (January 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. PMC 3260866. PMID 22201126.
  7. ^ Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (August 2012). "Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development". Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355. PMID 22753936.